TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation

Autor: Gökhan M. Mutlu, G. Gokalp, Leah J. Witt, Robert B. Hamanaka, Lucas M. Kimmig, Parker S. Woods, Recep Nigdelioglu, Angelo Y. Meliton, Yufeng Tian, Rengul Cetin-Atalay, E.M. O'Leary, Kaitlyn A. Sun

Publikováno v: Am J Respir Cell Mol Biol

Idiopathic pulmonary fibrosis is a fatal interstitial lung disease characterized by the TGF-β (transforming growth factor-β)–dependent differentiation of lung fibroblasts into myofibroblasts, which leads to excessive deposition of collagen protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ded04dd46279a2d6481b2a49d38bf3
https://doi.org/10.1165/rcmb.2020-0143oc

Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts

Autor: Leah J. Witt, Robert B. Hamanaka, Angelo Y. Meliton, Gökhan M. Mutlu, E.M. O'Leary, G. Gokalp, Yufeng Tian, Nickolai O. Dulin

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 61:597-606

Idiopathic pulmonary fibrosis (IPF) is characterized by the transforming growth factor (TGF)-β-dependent differentiation of lung fibroblasts into myofibroblasts, leading to excessive deposition of extracellular matrix proteins, which distort lung ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f023e86c26d4c6c2778b98094d4de354
https://doi.org/10.1165/rcmb.2019-0008oc

Glutamine Is Required for Mitochondrial Respiration and Differentiation of Skeletal Muscle Cells

Autor: Gökhan M. Mutlu, R.C. Atalay, G. Gokalp, D. Zhao, Yufeng Tian, Robert B. Hamanaka

Publikováno v: C59. DISSECTING ACUTE LUNG INJURY AND ARDS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbfc8a2500defedbbec7a23c9c8de645
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5595

P697New indices for a best quantification of left ventricular function in heart valve diseasesP698Intrapatient comparison of three echocardiographic techniques of determination of left ventricular (LV) longitudinal strain, and evaluation of their respective relationship to ejection fractionP699Myocardial strain as an early marker of cardiac dysfunction in a large cohort of anthracycline-treated pediatric cancer survivors?P700Resting 2D speckle tracking echocardiography for the prediction of death 5 years after ST- elevation myocardial infarctionP701Use of fully automated software to quantify left ventricular ejection fraction and left ventricular global longitudinal strainP702Can two-dimensional speckle tracking echocardiography be useful for the left ventricular assessment in the early stages of hereditary hemochromatosis?P703Assessment of left ventricular ejection fraction, global longitudinal strain and mechanical dispersion in acute myocardial infarction after revascularization with percutaneous coronary interventionP704Echocardiographic predictors of worse outcome in patients with ischemic chronic heart failure and renal disfunctionP705Impact of volume overload on right ventricular systolic and diastolic functions evaluated by speckle tracking echocardiographyP706Detection and localisation of obstructive coronary artery disease in chronic stable angina by myocardial deformation parmaters using tissue doppler imagingP707The determinants of deleterious effects of diabetes on the myocardiumP708Echocardiographic evaluation of the left atrium function after catheter ablation of long-standing persistent atrial fibrillationP709Early assessment of chemotherapy-related cardiovascular toxicity: an integrated evaluation through global longitudinal strain and arterial stiffness studyP710Prognostic value of right atrial 3-dimensional speckle tracking in different types of pulmonary arterial hypertensionP711Assessment of biventricular strain by 3-dimensional speckle-tracking echocardiography in chronic aortic regurgitation

Autor: L. Capotosto, E. Cambronero Cortinas, C. Zito, AI. Kazakov, MGM Gouda, RR. Dandu, S. Unlu, D. Lashkul, TM. Nguyen, L. Danilowicz-Szymanowicz, V. Sokalskis, E. Szymczyk, MG. Slieker, D. De Zuttere, A. Hubert, E. Galli, G. Bouzille, E. Samset, E. Donal, H. Lardoux, R. Rocha, A. Kone, P. Meimoun, C. Fackoury, C. Slorach, W. Hui, P. Liu, PF. Kantor, S. Mital, PC. Nathan, L. Mertens, P. Lipiec, BW. Michalski, K. Szymczyk, JD. Kasprzak, P. Aruta, D. Cherata, D. Muraru, LP. Badano, M. Fijalkowski, K. Rozwadowska, D. Kaufmann, K. Sikorska, R. Galaska, M. Gruchala, G. Raczak, D. Melichova, B. Grenne, B. Sjoli, OA. Smiseth, KH. Haugaa, T. Edvardsen, H. Brunvand, A. Sahinarslan, G. Gokalp, O. Seckin, A. Cengel, D. Raja, S. Kumar, N. Garg, S. Tewari, A. Kapoor, PK. Goel, M. D'angelo, MG. Daffina, M. Zucco, R. Costantino, R. Manganaro, L. Longobardo, F. Albiero, M. Cusma Piccione, G. Nucifora, A. Caprino, ML. Carerj, F. Antonini Canterin, O. Vriz, S. Carerj, J. Grapsa, A. Valle-Munoz, MJ. Corbi-Pascual, W. Gin-Sing, D. Dawson, L. Howard, F. Ridocci-Soriano, S. Gibbs, P. Nihoyannopoulos, R. Ashurov, E. Mangieri, C. Gaudio, A. Vitarelli

Publikováno v: European Heart Journal – Cardiovascular Imaging. 17:ii143-ii147

Aims. The Assessment of left ventricular (LV) function remains a clinical challenge especially in patients with preserved LV ejection fraction (EF) and valvular heart diseases (VHD). Mechanical dispersion is supposed to be a strong predictor of event

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4609679f9ccdd806c59c23fce177ada0
https://doi.org/10.1093/ehjci/jew250.003

De Novo Proline Synthesis Promotes Collagen Production in Human Lung Fibroblasts

Autor: E.M. O'Leary, Gökhan M. Mutlu, Recep Nigdelioglu, Parker S. Woods, David Wu, Yufeng Tian, Kaitlyn A. Sun, Nickolai O. Dulin, Leah J. Witt, G. Gokalp, Lucas M. Kimmig, Angelo Y. Meliton, Robert B. Hamanaka

Publikováno v: C62. FIBROBLAST BIOLOGY.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae9df06f3ed525e3b710bf5a1a6f778a
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5342