Výsledky vyhledávání

Muscarinic agonist SAR of azaspirodioxolanes

Autor: G. Gmelin, S Cottens, Porntip Supavilai, Georg Bolliger, P. Floersheim, Albert Enz, Rene Amstutz, Hendrikus Boddeke, Gideon Shapiro, P Gull

Publikováno v: Bioorganic & Medicinal Chemistry Letters, 2(8), 815-820. American Chemical Society

The in vitro muscarinic activity and a model for binding to the m1 receptor are presented for a series of azaspirodioxolanes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7d8020f328bfb42e4bc76f609ff74a
https://doi.org/10.1016/s0960-894x(00)80537-5

Zobrazit plný text záznamu

Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogs of pilocarpine and a hypothetical model for the binding of agonists to the M1 receptor

Autor: Gideon Shapiro, Porntip Supavilai, Georg Bolliger, P. Floersheim, G. Gmelin, Rene Amstutz, Malcolm D. Walkinshaw, J. Boelsterli, H. Gammenthaler

Publikováno v: Journal of Medicinal Chemistry. 35:15-27

Pilocarpine isosteres have been synthesized and characterized with regard to their in vitro muscarinic properties. The results indicate that the carbonyl oxygen of the lactone function of pilocarpine is of primary importance for agonist activity with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5957f0c6217643396b6d81d8eb947d4
https://doi.org/10.1021/jm00079a002

Zobrazit plný text záznamu

SDZ ENA 713, an Acetylcholinesterase-Inhibitor with Preference for Central Activity: Animal Studies

Autor: A. Hofmann, P. H. Kelly, A. Enz, R. Amstutz, G. Gmelin

Publikováno v: Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases ISBN: 9781468458497
Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47bee241cfe0494d0d415658fd8d5645
https://doi.org/10.1007/978-1-4684-5847-3_86

Zobrazit plný text záznamu

Muscarinic receptors on intact, cultured neurons. Characterization by [3H]quinuclidinylbenzilate binding

Autor: F. Hefti, W. Frick, A. Dravid, G. Gmelin, K. Citherlet

Publikováno v: Neuroscience Letters. 40:45-50

[3H]Quinuclidinylbenzilate (QNB) was used to identify muscarinic cholinergic receptors on intact, cultured neurons from fetal rat brains. Scatchard analysis revealed a single binding site with a dissociation constant Kd = approximately or equal to 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc705d32b6f4b415894060d3cff6e31
https://doi.org/10.1016/0304-3940(83)90090-3

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání