Zobrazeno 1 - 10
of 24
pro vyhledávání: '"G. G. Martinovich"'
Autor:
N. K. Zenkov, A. V. Chehushkov, P. M. Kozhin, G. G. Martinovich, N. V. Kandalintseva, E. B. Menshchikova
Publikováno v:
Бюллетень сибирской медицины, Vol 18, Iss 2, Pp 195-214 (2019)
Autophagy is the main catabolic process required for the removal of damaged organelles, aggregated proteins and intracellular pathogens from cells. Oxidative stress is accompanied by an increase in autophagy, which has a protective effect by maintain
Externí odkaz:
https://doaj.org/article/3dd073a9e9164a6eaa1e66ede1017681
Autor:
N. K. Zenkov, P. M. Kozhin, A. V. Vcherashnyaya, G. G. Martinovich, N. V. Kandalintseva, E. B. Menshchikova
Publikováno v:
Сибирский научный медицинский журнал, Vol 39, Iss 2, Pp 11-26 (2019)
Endogenous mechanisms of reactive oxygen (ROS) and nitrogen species production and of antioxidant defense systems in tumor cells are analyzed. Increased ROS production is an important regulator of metabolic changes in these cells: enhanced proliferat
Externí odkaz:
https://doaj.org/article/57059c42a168468798b406cd20866ae2
Autor:
P. I. Gaynutdinov, P. M. Kozhin, A. V. Chechushkov, G. G. Martinovich, S. V. Kholshin, N. V. Kandalintseva, N. K. Zenkov, E. B. Menshchikova
Publikováno v:
Сибирский научный медицинский журнал, Vol 38, Iss 1, Pp 22-31 (2019)
The aim of the study was to study investigate the relationship between the antioxidant activity of new synthetic structurally related water-soluble monophenols and their effect on the tumor cell viability in vitro. Material and methods. Five original
Externí odkaz:
https://doaj.org/article/9aee845f3df24acb8dba91409904e7aa
Autor:
V. V. Voinarovski, G. G. Martinovich
Publikováno v:
Biophysics. 67:734-743
Autor:
V. V. Voinarouski, G. G. Martinovich
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 16:91-105
Autor:
Sergey N. Cherenkevich, E. B. Menshchikova, G. G. Martinovich, N. K. Zenkov, I. V. Martinovich, A. V. Vcherashniaya
Publikováno v:
Biophysics. 65:920-930
Pharmacological modification of the redox properties of tumor cells is a promising approach to enhance the efficiency of antitumor therapy. The Nrf2 transcription factor is considered as a new target for the development of selective chemosensitizers.
Autor:
I. V. Martinovich, A. V. Vcherashniaya, Sergey N. Cherenkevich, Oleg I. Shadyro, G. G. Martinovich
Publikováno v:
Journal of Applied Spectroscopy. 87:515-519
Fluorescence assay and Raman spectroscopy were used to study the mechanisms of action of 2-isopropyl-5-methyl- 1,4-benzoquinone (thymoquinone) on HEp-2 human larynx carcinoma cells. Thymoquinone was found to have a more pronounced toxic effect than 1
Autor:
N. V. Kandalintseva, N. K. Zenkov, E. B. Menshchikova, P. M. Kozhin, S. V. Kholshin, G. G. Martinovich, A. V. Chechushkov
Publikováno v:
Cell and Tissue Biology. 13:85-92
The effect of novel water-soluble structurally related monophenolic compounds on the activity of two most important mechanisms of maintaining intracellular homeostasis, autophagy and the redox-sensitive signal system Keap1/Nrf2/ARE, has been studied
Autor:
N K, Zenkov, P M, Kozhin, A V, Chechushkov, N V, Kandalintseva, G G, Martinovich, E V, Menshchikova
Publikováno v:
Advances in gerontology = Uspekhi gerontologii. 33(1)
The free-radical theory of aging, advanced more than 50 years ago by D.Harman, remains popular today. The review analyzes age-related changes in the main endogenous mechanisms of reactive oxygen species (ROS) production and antioxidant defense mechan
Autor:
N. V. Kandalintseva, P. M. Kozhin, A. V. Chechushkov, N. K. Zenkov, E. B. Menshchikova, G. G. Martinovich
Publikováno v:
Biochemistry (Moscow). 82:556-564
Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated diseases. Under normal conditions, Nrf2 transcriptional activity is low due to its rapid ubiquit