Zobrazeno 1 - 10 of 21 pro vyhledávání: '"G. G. Dubinina"'
1
Condensed isoquinolines 30. Acylation and alkylation of 5,13-dihydro-11H-isoquino-[3,2-b]quinazolin-11-one
Autor: L. M. Potikha, Andrei A. Tolmachev, V. A. Kovtunenko, G. G. Dubinina, R. M. Gutsul
Publikováno v: Chemistry of Heterocyclic Compounds. 44:585-593
It was shown that 6-acyl-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-ones are formed when 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one is heated with the chlorides and anhydrides of carboxylic acids in the presence of bases (pyridine, NaOAc) w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41581988bbde046714510992b6ae2e60
https://doi.org/10.1007/s10593-008-0078-5
Zobrazit plný text záznamu
2
In Silico Design of Protein Kinase Inhibitors: Successes and Failures
Autor: Andriy O. Tolmachov, Petro O. Borisko, Alexander A. Shtil, G. G. Dubinina, Galina V. Ostrovska, M. O. Platonov, Oleksandr O. Chupryna
Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 7:171-188
Protein kinases are among the most exploited targets in modern drug discovery due to key roles these enzymes play in human diseases including cancer. The in silico approach, an important part of rational design of protein kinase inhibitors, is founde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b54110b4329631a7313ba783721e56
https://doi.org/10.2174/187152007780058704
Zobrazit plný text záznamu
6
[Untitled]
Autor: Yu. M. Volovenko, G. G. Dubinina
Publikováno v: Chemistry of Heterocyclic Compounds. 38:336-343
We have established that when 5-chloro-6-[cyano(2,3-dihydro-1-R-benzo[d]azol-2-yl)methyl]-2,3-pyrazinedicarbonitriles are reacted with nucleophilic reagents (aliphatic and aromatic amines, hydrogen sulfide), annelation of the five-membered ring occur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e10c321897a135b583624ef7e88e7fe8
https://doi.org/10.1023/a:1015695522610
Zobrazit plný text záznamu
7
[Untitled]
Autor: G. G. Dubinina, Yu. M. Volovenko
Publikováno v: Chemistry of Heterocyclic Compounds. 38:219-225
It has been found that malonodinitrile and 2-(6-R1-oxo-3,4-dihydro-2-quinazolyl)acetonitrile in the presence of triethylamine undergo hetarylation by 5,6-dichloro-2,3-pyrazinedicarbonitrile at the active methylene group to give the triethylammonium s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be8711dbb0ff67fa9778d8fec189135e
https://doi.org/10.1023/a:1015399511473
Zobrazit plný text záznamu
8
Synthesis of condensed pyrrolo[b]pyrazines
Autor: Yu. M. Volovenko, G. G. Dubinina
Publikováno v: Chemistry of Heterocyclic Compounds. 35:1089-1093
Reaction of 2,3-dichloro-5,6-dicyanopyrazine with α-azahetarylacetonitriles gives α-(3-chloro-5,6-dicyanopyrazin-2-yl)-α-(2-azahetaryl)acetonitriles. Subsequent heating in pyridine causes an intramolecular cyclization to yield condensed pyrrolo[b]
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3a3a7824e28be9bc748881cd9ebd8cd
https://doi.org/10.1007/bf02251802
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje