Zobrazeno 1 - 10
of 72
pro vyhledávání: '"G. Eric Blair"'
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Cajal bodies (CBs) are major sub-nuclear structures in most eucaryotic cells. In human adenovirus 5 (Ad5) infection, CBs are reorganized into microfoci in the late phase of infection. Here we show that many CB protein components (p80-coilin,
Externí odkaz:
https://doaj.org/article/fba5d21e0f094aabb21460faa1457d28
Publikováno v:
Viruses, Vol 15, Iss 12, p 2311 (2023)
Nuclear bodies (NBs) are dynamic structures present in eukaryotic cell nuclei. They are not bounded by membranes and are often considered biomolecular condensates, defined structurally and functionally by the localisation of core components. Nuclear
Externí odkaz:
https://doaj.org/article/2268a2a19af4464b86f577b6a352d2e4
Autor:
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT Human adenovirus (Ad) E1A proteins have long been known as the central regulators of virus infection as well as the major source of adenovirus oncogenic potential. Not only do they activate expression of other early viral genes, they make vi
Externí odkaz:
https://doaj.org/article/3384865bcf664ed09b505b5af535d394
Autor:
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT The human adenovirus E4orf6/E1B55K E3 ubiquitin ligase is well known to promote viral replication by degrading an increasing number of cellular proteins that inhibit the efficient production of viral progeny. We report here a new function of
Externí odkaz:
https://doaj.org/article/c01a38eed5be44cc8477ec767683e17f
Autor:
Siu Yi Lee, G. Eric Blair, Christopher W. Wasson, Molly R. Patterson, Yigen Li, Ethan L. Morgan, Andrew Macdonald, Katherine L. Harper, Adrian Whitehouse, Emma L. Ryder, Stephen Griffin
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 6, p e1008624 (2020)
PLoS Pathogens, Vol 16, Iss 6, p e1008624 (2020)
Human papillomaviruses (HPV) are a major cause of malignancy worldwide. They are the aetiological agents of almost all cervical cancers as well as a sub-set of other anogenital and head and neck cancers. Hijacking of host cellular pathways is essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f790f0f257673bcea947648c172db203
https://eprints.whiterose.ac.uk/161071/8/journal.ppat.1008624.pdf
https://eprints.whiterose.ac.uk/161071/8/journal.ppat.1008624.pdf
Autor:
Gabrielė, Stakaitytė, Nnenna, Nwogu, Samuel J, Dobson, Laura M, Knight, Christopher W, Wasson, Francisco J, Salguero, David J, Blackbourn, G Eric, Blair, Jamel, Mankouri, Andrew, Macdonald, Adrian, Whitehouse
Publikováno v:
Journal of Virology
Cell motility and migration is a complex, multistep, and multicomponent process intrinsic to progression and metastasis. Motility is dependent on the activities of integrin receptors and Rho family GTPases, resulting in the remodeling of the actin cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efd399ddfb253e10651618b6ba7d44c8
https://pubmed.ncbi.nlm.nih.gov/29093086
https://pubmed.ncbi.nlm.nih.gov/29093086
Autor:
Gina B. Scott, Yasser M. El-Sherbiny, G. Eric Blair, Graham P. Cook, Terence H. Rabbitts, Josephine L. Meade, Tomoyuki Tanaka, Jehan J. El-Jawhari, Robin Prestwich, Ruth Morgan, Paul A. Bowles
Mutations in the RAS family of oncogenes are highly prevalent in human cancer and, amongst its manifold effects, oncogenic RAS impairs the expression of components of the antigen presentation pathway. This allows evasion of cytotoxic T lymphocytes (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3878183a9f7dd06bdf85b8a3d8243c82
https://ora.ox.ac.uk/objects/uuid:0f109c39-e694-4c30-8028-9aa3f3533e0a
https://ora.ox.ac.uk/objects/uuid:0f109c39-e694-4c30-8028-9aa3f3533e0a
Autor:
Philip E. Branton, Sabrina Schreiner, Paola Blanchette, Thomas Dobner, G. Eric Blair, Frédéric Dallaire
Publikováno v:
mSphere 1:e00014-15 (2015)
mSphere, Vol 1, Iss 1 (2016)
mSphere
mSphere, Vol 1, Iss 1 (2016)
mSphere
During the course of work on the adenovirus E3 ubiquitin ligase formed by the viral E4orf6 and E1B55K proteins, we found, very surprisingly, that expression of these species was sufficient to permit low levels of replication of an adenovirus vector l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e8d228350b53d4bf71a450569ce6bd
https://doi.org/10.1128/msphere.00014-15
https://doi.org/10.1128/msphere.00014-15
Autor:
Rebecca L. Caygill, Séamus P.J. Higson, Joanne L. Holmes, Paul A. Millner, Chris S. Hodges, G. Eric Blair
Publikováno v:
Biosensors and Bioelectronics. 32:104-110
The number of Adenovirus (Ad) infections detected in immunocompromised people has increased due to the number of patients receiving transplants, as well as the HIV pandemic. Ads cause life-threatening diseases specific to the infected organs of immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15a486ff636823c58fb5248330ebad6
https://doi.org/10.1016/j.bios.2011.11.041
https://doi.org/10.1016/j.bios.2011.11.041
Publikováno v:
Biochemical and Biophysical Research Communications. 405:417-421
A virally-encoded oncoprotein (E7 from human papillomavirus 16, involved in the initiation of cell transformation) was the target for RNA aptamer development by the process of systematic evolution of ligands by exponential enrichment (SELEX). A numbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadf8b229fa297f576ecca0190eb918c
https://doi.org/10.1016/j.bbrc.2011.01.044
https://doi.org/10.1016/j.bbrc.2011.01.044