Microbial Community Composition in Explanted Cystic Fibrosis and Control Donor Lungs

Autor: Gisli G. Einarsson, Bart M. Vanaudenaerde, Christopher D. Spence, Andrew J. Lee, Mieke Boon, Geert M. Verleden, J. Stuart Elborn, Lieven J. Dupont, Dirk Van Raemdonck, Deirdre F. Gilpin, Robin Vos, Stijn E. Verleden, Michael M. Tunney

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)

To date, investigations of the microbiota in the lungs of people with Cystic Fibrosis (PWCF) have primarily focused on microbial community composition in luminal mucus, with fewer studies observing the microbiota in tissue samples from explanted lung

Externí odkaz: https://doaj.org/article/e3be9f4b85574b029f366d976f295448

Multi-Omics Approaches: The Key to Improving Respiratory Health in People With Cystic Fibrosis?

Autor: Andrew J. Lee, Gisli G. Einarsson, Deirdre F. Gilpin, Michael M. Tunney

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

The advent of high-throughput multi-omics technologies has underpinned the expansion in lung microbiome research, increasing our understanding of the nature, complexity and significance of the polymicrobial communities harbored by people with CF (PWC

Externí odkaz: https://doaj.org/article/cffcc90dd08e4dbc978fbd6fc1d6820e

Community analysis and co-occurrence patterns in airway microbial communities during health and disease

Autor: Gisli G. Einarsson, Jiangchao Zhao, John J. LiPuma, Damian G. Downey, Michael M. Tunney, J. Stuart Elborn

Publikováno v: ERJ Open Research, Vol 5, Iss 3 (2019)

Ecological relationships between bacteria are important when considering variation in bacterial communities in humans, with such variation playing an important role in both health and disease. Using high-throughput sequence data of the 16S rRNA marke

Externí odkaz: https://doaj.org/article/52ae508bf7274590a489751702492841

A mechanistic analysis of the effect of valaciclovir for EBV suppression on airway inflammation and microbiome in COPD

Autor: D Linden, H Guo-Parke, G Einarsson, S Carson, A Lee, D Fairley, D Singh, M Tunney, D Mcauley, C Taggart, J Kidney

Publikováno v: 10.01 - Respiratory infections and bronchiectasis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cc532b870f645019686a03f0e235db2
https://doi.org/10.1183/23120541.lsc-2023.59

Extended-culture and culture-independent molecular analysis of the airway microbiota in cystic fibrosis following CFTR modulation with ivacaftor

Autor: Deirdre Gilpin, Barry J. Plant, Fergus Shanahan, J. Stuart Elborn, David Mullane, Joseph A. Eustace, Gisli G. Einarsson, N.J. Ronan, D. Mooney, M. Mccarthy, Desmond M. Murphy, Muireann NiChroinin, Michael M. Tunney, C. McGettigan, Yvonne McCarthy

Publikováno v: Einarsson, G G, Ronan, N J, Mooney, D, McGettigan, C, Mullane, D, NiChroinin, M, Shanahan, F, Murphy, D M, McCarthy, M, McCarthy, Y, Eustace, J A, Gilpin, D F, Elborn, J S, Plant, B J & Tunney, M M 2021, ' Extended-culture and culture-independent molecular analysis of the airway microbiota in cystic fibrosis following CFTR modulation with ivacaftor ', Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society . https://doi.org/10.1016/j.jcf.2020.12.023

BACKGROUND: Treatment with Ivacaftor provides a significant clinical benefit in people with cystic fibrosis (PWCF) with the class III G551D-CFTR mutation. This study determined the effect of CFTR modulation with ivacaftor on the lung microbiota in PW

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877ad0b01f143a4d9a8c943c92ad22db
https://doi.org/10.1016/j.jcf.2020.12.023