Výsledky vyhledávání - "G. E. Winterrowd"

Phenotypic characterization of T lymphocytes emigrating into lung tissue and the airway lumen after antigen inhalation in sensitized mice

Autor: Cheryl A. Hatfield, G. E. Winterrowd, Ivan M. Richards, Jia En Chin, Joseph V. Haas, Jeffrey D. Kennedy, Stephen F. Fidler

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 12:613-623

Cytokines released from CD4+ T lymphocytes contribute to the pathogenesis of asthma by influencing the differentiation and function of eosinophils, the primary effector cells that cause airway epithelial damage. Using a model of ovalbumin (OA)-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd02f0470545a93e7d3fdd2356e877f6
https://doi.org/10.1165/ajrcmb.12.6.7766426

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Regulation of expression of IL-1 receptor antagonist protein in human synovial and dermal fibroblasts

Autor: R F Krzesicki, C A Hatfield, M J Bienkowski, J C McGuire, G E Winterrowd, D L Chapman, A E Berger, R N McEwan, D B Carter, J G Chosay

Publikováno v: The Journal of Immunology. 150:4008-4018

The IL-1R antagonist protein (IRAP) is a competitive inhibitor of IL-1, which is predominantly synthesized by monocytes. We show that this molecule is also expressed in human synovial fibroblasts and dermal fibroblasts (CRL 1445). IRAP mRNA was regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe05f72949b21a5239f7dc50511eefa8
https://doi.org/10.4049/jimmunol.150.9.4008

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Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma

Autor: J E, Chin, C A, Hatfield, G E, Winterrowd, R F, Krzesicki, K L, Shull, S F, Fidler, K P, Kolbasa, J R, Brashler, R L, Griffin, W E, Fleming, J M, Justen, L S, Banitt, G L, Bundy, I M, Richards

Publikováno v: The Journal of pharmacology and experimental therapeutics. 290(1)

The anti-inflammatory properties of a novel pyrrolopyrimidine, PNU-142731A, in a murine model of antigen-induced eosinophilic lung inflammation are described. PNU-142731A, when given orally, demonstrated a dose-related inhibition of eosinophil- and l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::513c34a80c0895f815c9f4a616865c11
https://pubmed.ncbi.nlm.nih.gov/10381775

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Intercellular adhesion molecule-1-deficient mice have antibody responses but impaired leukocyte recruitment

Autor: I. M. Richards, S. F. Fidler, F. P. Bell, C. A. Hatfield, R. L. Griffin, Jia En Chin, J. L. Mobley, K. P. Kolbasa, J. R. Brashler, G. E. Winterrowd, Kathy L. Shull

Publikováno v: The American journal of physiology. 273(3 Pt 1)

The role of intercellular adhesion molecule-1 (ICAM-1) in murine lung inflammation was examined in vivo. Ovalbumin (Ova)-sensitized and -challenged ICAM-1-deficient (KO) mice had decreased accumulation of leukocytes in the bronchoalveolar lavage flui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ab712cc2a178cb8c900671d518e57d
https://pubmed.ncbi.nlm.nih.gov/9316484

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Identification of cytokine and adhesion molecule mRNA in murine lung tissue and isolated T cells and eosinophils by semi-quantitative reverse transcriptase-polymerase chain reaction

Autor: Robert L. Griffin, Cheryl A. Hatfield, Karen P. Kolbasa, Ivan M. Richards, Raymond F. Krzesicki, Jia En Chin, Kathy L. Shull, J. R. Brashler, G. E. Winterrowd, Stephen F. Fidler

Publikováno v: American journal of respiratory cell and molecular biology. 16(6)

We have used a semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) assay to detect the expression of mRNA for inflammatory cytokines, integrins and selectins in murine lung tissue, and T cells and eosinophils isolated from lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109d85b1591d954b6406cc21edf7c74c
https://pubmed.ncbi.nlm.nih.gov/9191471

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Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1

Autor: Jia En Chin, G. E. Winterrowd, R. L. Griffin, R. F. Krzesicki, J. R. Brashler, S. F. Fidler, K. P. Kolbasa, S. L. Vonderfecht, C. A. Hatfield, L. M. Sly, I. M. Richards, N. D. Staite

Publikováno v: The American journal of physiology. 272(2 Pt 1)

The involvement of the alpha4-integrin very late activation antigen 4 and vascular cell adhesion molecule-1 (VCAM-1) in leukocyte trafficking into the airways of ovalbumin (OA)-sensitized and OA-challenged mice was investigated using in vivo administ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407822464f9d6f3bbf5f4250b1569635
https://pubmed.ncbi.nlm.nih.gov/9124372

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Phenotypic analysis of airway eosinophils and lymphocytes in a Th-2-driven murine model of pulmonary inflammation

Autor: George A. Conder, Jia En Chin, Stephen T. Holgate, Frank F. Sun, S. L. Vonderfecht, G. E. Winterrowd, Stephen F. Fidler, A. D. Watkins, Bruce M. Taylor, Ivan M. Richards, J. R. Brashler, Cheryl A. Hatfield

Publikováno v: American journal of respiratory cell and molecular biology. 15(1)

In order to investigate whether the pulmonary response to helminth antigens mimics that seen in allergic inflammation of the airways, we have examined the phenotypic characteristics of lymphocytes and eosinophils recruited to the airways following Ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9d4694d7e2ca612a014d8411c1af2f
https://pubmed.ncbi.nlm.nih.gov/8679219

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Regulation of expression of IL-1 receptor antagonist protein in human synovial and dermal fibroblasts

Autor: R F, Krzesicki, C A, Hatfield, M J, Bienkowski, J C, McGuire, G E, Winterrowd, D L, Chapman, A E, Berger, R N, McEwan, D B, Carter, J G, Chosay

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 150(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f7cebd9e31f041fd13bd2c58706a677
https://pubmed.ncbi.nlm.nih.gov/8473746

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Beta-carotene's effects on serum lipoproteins and immunologic indices in humans

Autor: Thomas V. Ringer, S K Gaylor, Steven F. Francom, G E Winterrowd, Michael J. DeLoof, George S. Hughes, J A Ryan, Martin E. Sanders

Publikováno v: The American journal of clinical nutrition. 53(3)

Doses of beta-carotene for cancer-prevention trials have been chosen based on epidemiologic data. Mechanisms of the putative antineoplastic effects by beta-carotene are unknown but may involve modulation of the immune system. We measured plasma carot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9349e57af3244caadb1d7a6d08bead
https://pubmed.ncbi.nlm.nih.gov/1877522

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Role of cytokines in inflammatory synovitis. The coordinate regulation of intercellular adhesion molecule 1 and HLA class I and class II antigens in rheumatoid synovial fibroblasts

Autor: J E, Chin, G E, Winterrowd, R F, Krzesicki, M E, Sanders

Publikováno v: Arthritis and rheumatism. 33(12)

This study was undertaken in an effort to understand the role of cytokines in T lymphocyte trafficking into inflamed synovium and in the potential enhancement of antigen presentation by human synovial fibroblasts. We found that interleukin-1 beta (IL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e9470a19cf1872b9a513892e3a79a17
https://pubmed.ncbi.nlm.nih.gov/1701992

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