Zobrazeno 1 - 10 of 19 pro vyhledávání: '"G. E. Shafer"'
1
Interleukin-2-transduced lymphocytes grow in an autocrine fashion and remain responsive to antigen
Autor: Richard A. Morgan, Steven A. Rosenberg, R Cowherd, G. E. Shafer, Seijiro Minamoto, Patrick Hwu, J. Treisman
Publikováno v: Blood. 85:139-145
The maintenance of T lymphocytes in vivo after adoptive transfer for immunotherapy requires the systemic administration of interleukin-2 (IL- 2), but prolonged administration of IL-2 is associated with substantial toxicity. The constitutive productio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73afd27f85450438ef81092f641e581b
https://doi.org/10.1182/blood.v85.1.139.bloodjournal851139
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2
Retrovirus-mediated transfer and expression of an allogeneic major histocompatibility complex class II DRB cDNA in swine bone marrow cultures
Autor: D W, Emery, G E, Shafer, E M, Karson, D H, Sachs, C, LeGuern
Publikováno v: Blood. 81:2460-2465
The possibility of inducing transplantation tolerance by somatic gene transfer is under investigation in our miniature swine model. As a crucial step in this project, we have used a retroviral vector engineered to express both a drug-resistance gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f16ab79a295395adeae0d6974feccb
https://doi.org/10.1182/blood.v81.9.2460.bloodjournal8192460
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3
In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes
Autor: P, Hwu, J C, Yang, R, Cowherd, J, Treisman, G E, Shafer, Z, Eshhar, S A, Rosenberg
Publikováno v: Cancer research. 55(15)
In an effort to broaden the applicability of adoptive cellular immunotherapy toward nonmelanoma cancers, we have designed chimeric antibody/T-cell receptor genes composed of the variable domains from mAbs joined to T-cell receptor-signaling chains. W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4633c1c07ce10e43388524044adc8125
https://pubmed.ncbi.nlm.nih.gov/7614473
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5
Interleukin-2-transduced lymphocytes grow in an autocrine fashion and remain responsive to antigen
Autor: J, Treisman, P, Hwu, S, Minamoto, G E, Shafer, R, Cowherd, R A, Morgan, S A, Rosenberg
Publikováno v: Blood. 85(1)
The maintenance of T lymphocytes in vivo after adoptive transfer for immunotherapy requires the systemic administration of interleukin-2 (IL-2), but prolonged administration of IL-2 is associated with substantial toxicity. The constitutive production
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c823595d09d69002c750727fe578955a
https://pubmed.ncbi.nlm.nih.gov/7803791
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6
Upregulation of tumor necrosis factor-alpha production by retrovirally transduced human tumor-infiltrating lymphocytes using trans-retinoic acid
Autor: Patrick Hwu, R Cowherd, J. Treisman, G. E. Shafer, John R. Yannelli, Steven A. Rosenberg, Dvorit Samid
Publikováno v: Cellular immunology. 156(2)
The ability of retinoic acid (RA) to upregulate gene expression in human tumor-infiltrating lymphocytes (TIL) transduced with a Moloney murine leukemia virus containing the cDNA encoding tumor necrosis factor (TNF) has been studied. TNF production wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e130a85757c687b907fd8850ea3fc676
https://pubmed.ncbi.nlm.nih.gov/8025957
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7
Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain
Autor: Steven A. Rosenberg, J. Treisman, Daniel Schindler, G. E. Shafer, R Cowherd, Zelig Eshhar, Gideon Gross, P Hwu
Publikováno v: The Journal of Experimental Medicine
To expand the spectrum of recognition of effector lymphocytes and to redirect them towards predefined targets, we have altered the specificity of human tumor-infiltrating lymphocytes (TIL) through stable modification with chimeric receptor genes cons
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad0a7ec69a0a12c52c392fb88ad868e
https://pubmed.ncbi.nlm.nih.gov/8315392
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10
Expression of a swine class II gene in murine bone marrow hematopoietic cells by retroviral-mediated gene transfer
Autor: Karin Gustafsson, David H. Sachs, G. E. Shafer, Christian LeGuern, David W. Emery, Sharon Germana, Wayne F. Anderson
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 88(21)
As a first step in assessing the efficacy of a gene transfer approach to the induction of transplantation tolerance in our miniature swine model, double-copy retroviral vectors engineered to express a drug-resistance marker (neomycin) and a swine cla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d289b16101d99b6770ae442efea26b
https://pubmed.ncbi.nlm.nih.gov/1946400
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