Zobrazeno 1 - 10
of 11
pro vyhledávání: '"G. E. Padbury"'
Autor:
Gordon L. Bundy, Harvey Irving Skulnick, L. N. Toth, Johnson Paul D, Theresa M. Schwartz, Paul K. Tomich, Strohbach Joseph Walter, J. C. Lynn, Thomas J. Raub, G. E. Padbury, R. R. Hinshaw, Kong Teck Chong, Suvit Thaisrivongs
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:399-402
The sulfonamide substituted pyranones ( 1 ) have recently been shown to be potent HIV protease inhibitors. We prepared a series of sulfone substituted analogs and compared their biological activities to those of the corresponding sulfonamide analogs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffaf77505ab59535afb537a7257e91ac
https://doi.org/10.1016/s0960-894x(97)00031-0
https://doi.org/10.1016/s0960-894x(97)00031-0
Autor:
Schwartz Tm, G L Bundy, K A Koeplinger, J. K. Mayo, G. E. Padbury, Zhiyang Zhao, Harbach Pr, Zimmermann Dc, C.S. Aaron, M J Hauer, L S Banitt
Publikováno v:
Chemical Research in Toxicology. 9:1230-1239
U-89843 is a novel pyrrolo[2,3-d]pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During preclinical safety evaluation, U-89843 was found to give a positive response in the in vitro unscheduled DNA synthesis (U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac451d727323d1cb8f441d48692d44a6
https://doi.org/10.1021/tx960092z
https://doi.org/10.1021/tx960092z
Autor:
G. E. Padbury, P. G. Larson, C. S. Aaron, L. S. Banitt, K. L. Linseman, J. K. Mayo, J. E. Chin, P. A. Yonkers, Heidi M. Scherch, E. D. Hall, Stephen A. Mizsak, K. L. Belonga, Gordon L. Bundy, J. M. Lin, F. F. Sun, J. M. Tustin, I. M. Richards, Donald E. Ayer, John R. Palmer
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e41174a634527607b1c5c03a355d49
https://doi.org/10.1002/chin.199607175
https://doi.org/10.1002/chin.199607175
Autor:
Johnson Paul D, Gordon L. Bundy, Theresa M. Schwartz, Harvey Irving Skulnick, Thomas J. Raub, G. E. Padbury, L. N. Toth, Paul K. Tomich, Strohbach Joseph Walter, J. C. Lynn, Kong Teck Chong, Suvit Thaisrivongs, R. R. Hinshaw
Publikováno v:
ChemInform. 28
The sulfonamide substituted pyranones ( 1 ) have recently been shown to be potent HIV protease inhibitors. We prepared a series of sulfone substituted analogs and compared their biological activities to those of the corresponding sulfonamide analogs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5f49762b2caee67900fc60eead40803
https://doi.org/10.1002/chin.199724142
https://doi.org/10.1002/chin.199724142
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(3)
Oxidative stress is considered a cause or propagator of acute and chronic disorders of the central nervous system. Novel 2, 4-diamino-pyrrolo[2,3-d]pyrimidines are potent inhibitors of iron-dependent lipid peroxidation, are cytoprotective in cell cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::316a9bdd761d4fb88ac7cc0794c817cc
https://pubmed.ncbi.nlm.nih.gov/10027873
https://pubmed.ncbi.nlm.nih.gov/10027873
Autor:
G E, Padbury, G L, Zipp, F J, Schwende, Z, Zhao, K A, Koeplinger, K T, Chong, T J, Raub, S, Thaisrivongs
Publikováno v:
Pharmaceutical biotechnology. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe2c137ac24d3740e61a3e15a03f2086
https://pubmed.ncbi.nlm.nih.gov/9760682
https://pubmed.ncbi.nlm.nih.gov/9760682
Publikováno v:
Chirality. 10(3)
PNU-103017, 4-Cyano-N-(3-(cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy- 2-oxo-2H-cycloocta(b) pyran-3-yl)methyl)phenyl)-benzenesulfonamide, is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of Acquired Immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::275eed40c07b4f6409d8c89def961856
https://pubmed.ncbi.nlm.nih.gov/9499572
https://pubmed.ncbi.nlm.nih.gov/9499572
Autor:
E D, Hall, P K, Andrus, S L, Smith, T J, Fleck, H M, Scherch, B S, Lutzke, G A, Sawada, J S, Althaus, P F, Vonvoigtlander, G E, Padbury, P G, Larson, J R, Palmer, G L, Bundy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
A novel group of antioxidant compounds, the pyrrolopyrimidines, has been discovered recently. Many of these possess significantly improved oral bioavailability (56-70% in rats), increased efficacy and potency in protecting cultured neurons against ir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cda9d59b6e3e37f452e3b016753fb48c
https://pubmed.ncbi.nlm.nih.gov/9152399
https://pubmed.ncbi.nlm.nih.gov/9152399
Autor:
Z, Zhao, K A, Koeplinger, G E, Padbury, M J, Hauer, G L, Bundy, L S, Banitt, T M, Schwartz, D C, Zimmermann, P R, Harbach, J K, Mayo, C S, Aaron
Publikováno v:
Chemical research in toxicology. 9(8)
U-89843 is a novel pyrrolo[2,3-d]pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During preclinical safety evaluation, U-89843 was found to give a positive response in the in vitro unscheduled DNA synthesis (U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b0d73d329f6bb628483afbc4c0cecfb
https://pubmed.ncbi.nlm.nih.gov/8951224
https://pubmed.ncbi.nlm.nih.gov/8951224
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(2)
The biotransformation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) has been studied in rat both in vitro and in vivo. Major metabolites observed by HPLC analysis of rat plasma, liver cytosol, and microsomal incubations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa8bc43ffa41a75f97e829d937ee7089
https://pubmed.ncbi.nlm.nih.gov/8742230
https://pubmed.ncbi.nlm.nih.gov/8742230