Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97

Autor: G, Escherich, M A, Horstmann, M, Zimmermann, G E, Janka-Schaub, J, Dohrn

Publikováno v: Leukemia. 24:298-308

In this study, the long-term outcome of 1818 patients treated in five consecutive clinical trials (the cooperative study group for childhood acute lymphoblastic leukaemia (COALL) 82, 85, 89, 92 and 97) from 24 cooperating centres in Germany is report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5882119b7f006620e9f817c988351e51
https://doi.org/10.1038/leu.2009.249

Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensivity and clinical outcome

Autor: G. E. Janka-Schaub, R. X de Menezes, W A G Stams, E. R. Van Wering, M L den Boer, Rob Pieters, A. H. Loonen, E van Drunen, N L Ramakers-van-Woerden, R L Stigter, H B Beverloo

Publikováno v: Leukemia, 20, 410-416. Nature Publishing Group

Clinical heterogeneity within t(12;21) or TEL/AML1-positive ALL (25% of childhood common/preB ALL) indicates that additional genetic changes might contribute to outcome. We studied the relation between additional genetic changes in TEL(ETV6) and AML1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb66404e434a64819b037cc43aea5b1
https://pure.eur.nl/en/publications/15f4b858-62f1-4066-b318-97974154c3f7

Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia

Autor: Rob Pieters, M L den Boer, Stephen E. Sallan, G. E. Janka-Schaub, Monique Passier, Ronald W. Stam, Scott A. Armstrong

Publikováno v: Leukemia, 20, 264-271. Nature Publishing Group

MLL rearranged acute lymphoblastic leukemia (MLL) is an aggressive type of acute lymphoblastic leukemia (ALL), diagnosed predominantly in infants (1 years of age). Since current chemotherapy fails in50% of patients with MLL, new therapeutic strategie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ddfefc8c6f3b16fa2888f7a0cd1512
https://hdl.handle.net/1765/70694

In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype

Autor: M L den Boer, Jochen Harbott, E. R. Van Wering, A H Loonen, Bruce M. Camitta, G. E. Janka-Schaub, Rosalyn Slater, W.-D. Ludwig, Rob Pieters, N L Ramakers-van Woerden, Anjo J.P. Veerman, H B Beverloo, Oskar A. Haas

Publikováno v: Leukemia, 18(3), 521-9. Nature Publishing Group
Ramakers-van Woerden, NL, Beverloo, HB, Veerman, A J P, Camitta, BM, Loonen, A H, van Wering, E R, Slater, RM, Harbott, J, den Boer, M L, Ludwig, WD, Haas, OA & Janka-Schaub, GE 2004, ' In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype. ', Leukemia, vol. 18, no. 3, pp. 521-9 . https://doi.org/10.1038/sj.leu.2403253
Leukemia, 18, 521-529. Nature Publishing Group

Acute lymphoblastic leukemia (ALL) in infants under 1 year is strongly associated with translocations involving 11q23 (MLL gene), CD10-negative B-lineage (proB) immunophenotype, and poor outcome. The present study analyses the relationship between ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb65991c3bb2238ae6d2e837d6e4829b
https://doi.org/10.1038/sj.leu.2403253

In vitro drug resistance and prognostic impact of p16INK4A /P15INK4B deletions in childhood T-cell acute lymphoblastic leukaemia

Autor: Marianne G. Rots, Mats Heyman, Willem Kamps, Rob Pieters, E van Drunen, A H Loonen, H B Beverloo, N. L. Ramakers-Van Woerden, TC Moreno, E. R. Van Wering, G. E. Janka-Schaub, Rosalyn Slater, A. J. P. Veerman

Publikováno v: British Journal of Haematology. 112:680-690

p16 gene deletions are present in about 70% of primary paediatric T-cell acute lymphoblastic leukaemia (T-ALL) and 20% of common/precursor B-cell ALL cases. It is not clear what the impact of the frequent p16 deletions is within the subgroup of T-lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1918a9bea135a73990af8ba275decb3
https://doi.org/10.1046/j.1365-2141.2001.02586.x