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Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97

Autor: G, Escherich, M A, Horstmann, M, Zimmermann, G E, Janka-Schaub, J, Dohrn

Publikováno v: Leukemia. 24:298-308

In this study, the long-term outcome of 1818 patients treated in five consecutive clinical trials (the cooperative study group for childhood acute lymphoblastic leukaemia (COALL) 82, 85, 89, 92 and 97) from 24 cooperating centres in Germany is report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5882119b7f006620e9f817c988351e51
https://doi.org/10.1038/leu.2009.249

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Reduced Expression and Defective Modulation of TNF Receptor/Ligand Family Molecules on proB-ALL Blasts

Autor: Ulrich Göbel, Birgit Ackermann, L Glouchkova, Dagmar Dilloo, Gabriele Escherich, Helmut Hanenberg, G. E. Janka-Schaub, Meinolf Siepermann, Anja Troeger

Publikováno v: Klinische Pädiatrie. 220:353-357

BACKGROUND: There is a subgroup of pediatric patients with an immature immunophenotype of proB-ALL that still poses a therapeutic challenge, even if the overall prognosis in B cell precursor acute lymphoblasic leukemia (BCP-ALL) is very good. Due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bfaa18948336ee8e203ef73026bd41
https://doi.org/10.1055/s-0028-1086028

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Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensivity and clinical outcome

Autor: G. E. Janka-Schaub, R. X de Menezes, W A G Stams, E. R. Van Wering, M L den Boer, Rob Pieters, A. H. Loonen, E van Drunen, N L Ramakers-van-Woerden, R L Stigter, H B Beverloo

Publikováno v: Leukemia, 20, 410-416. Nature Publishing Group

Clinical heterogeneity within t(12;21) or TEL/AML1-positive ALL (25% of childhood common/preB ALL) indicates that additional genetic changes might contribute to outcome. We studied the relation between additional genetic changes in TEL(ETV6) and AML1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb66404e434a64819b037cc43aea5b1
https://pure.eur.nl/en/publications/15f4b858-62f1-4066-b318-97974154c3f7

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Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia

Autor: M. Meier, Jules P.P. Meijerink, Rob Pieters, M L den Boer, Mathilde J.C. Broekhuis, E. R. Van Wering, G. E. Janka-Schaub, Monique Passier

Publikováno v: Leukemia, 20, 1377-1384. Nature Publishing Group

The T-lineage phenotype of childhood acute lymphoblastic leukaemia (ALL) is associated with an increased relapse-risk and in vitro resistance to drugs as compared to a precursor B phenotype. Antiapoptotic isoforms of p73 that lack part of the transac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee0606d8ee54e0d2f81d2e795d53209
https://doi.org/10.1038/sj.leu.2404288

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Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia

Autor: Rob Pieters, M L den Boer, Stephen E. Sallan, G. E. Janka-Schaub, Monique Passier, Ronald W. Stam, Scott A. Armstrong

Publikováno v: Leukemia, 20, 264-271. Nature Publishing Group

MLL rearranged acute lymphoblastic leukemia (MLL) is an aggressive type of acute lymphoblastic leukemia (ALL), diagnosed predominantly in infants (1 years of age). Since current chemotherapy fails in50% of patients with MLL, new therapeutic strategie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ddfefc8c6f3b16fa2888f7a0cd1512
https://hdl.handle.net/1765/70694

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Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia

Autor: Monique L. den Boer, Anne R. M. von Bergh, Rob Pieters, H. Berna Beverloo, Karin M. Kazemier, G. E. Janka-Schaub, Amy Holleman

Publikováno v: Blood, 106(5), 1817-1823. American Society of Hematology

Drug resistance in childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) is associated with impaired ability to induce apoptosis. To elucidate causes of apoptotic defects, we studied the protein expression of Apaf-1, procaspas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6502732fab4542698952186b965fe3a
https://doi.org/10.1182/blood-2004-11-4296

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In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype

Autor: M L den Boer, Jochen Harbott, E. R. Van Wering, A H Loonen, Bruce M. Camitta, G. E. Janka-Schaub, Rosalyn Slater, W.-D. Ludwig, Rob Pieters, N L Ramakers-van Woerden, Anjo J.P. Veerman, H B Beverloo, Oskar A. Haas

Publikováno v: Leukemia, 18(3), 521-9. Nature Publishing Group
Ramakers-van Woerden, NL, Beverloo, HB, Veerman, A J P, Camitta, BM, Loonen, A H, van Wering, E R, Slater, RM, Harbott, J, den Boer, M L, Ludwig, WD, Haas, OA & Janka-Schaub, GE 2004, ' In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype. ', Leukemia, vol. 18, no. 3, pp. 521-9 . https://doi.org/10.1038/sj.leu.2403253
Leukemia, 18, 521-529. Nature Publishing Group

Acute lymphoblastic leukemia (ALL) in infants under 1 year is strongly associated with translocations involving 11q23 (MLL gene), CD10-negative B-lineage (proB) immunophenotype, and poor outcome. The present study analyses the relationship between ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb65991c3bb2238ae6d2e837d6e4829b
https://doi.org/10.1038/sj.leu.2403253

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