Zobrazeno 1 - 10
of 589
pro vyhledávání: '"G. Dunlop"'
Autor:
S. Grewal, R. T. Theijse, G. Dunlop, D. F. P. van Deurzen, M. P. J. van den Bekerom, R. J. M. Klautz, R. P. Lefebvre, D. Munsami, N. Grewal
Publikováno v:
Frontiers in Sports and Active Living, Vol 6 (2024)
BackgroundProfessional athletes navigate a multitude of unique challenges associated to sport-specific factors (e.g., training, travel and competition) and non-sport factors (e.g., performance pressure, stress and anxiety) that can interfere with hea
Externí odkaz:
https://doaj.org/article/d6fa70a289b14d10bf89b7ea0c36d1e0
Autor:
Bradley T. Harris, Vidya Rajasekaran, James P. Blackmur, Alan O’Callaghan, Kevin Donnelly, Maria Timofeeva, Peter G. Vaughan-Shaw, Farhat V. N. Din, Malcolm G. Dunlop, Susan M. Farrington
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Colorectal cancer (CRC) is characterised by heritable risk that is not well understood. Heritable, genetic variation at 11q23.1 is associated with increased colorectal cancer (CRC) risk, demonstrating eQTL effects on 3 cis- and 23 trans-eQTL
Externí odkaz:
https://doaj.org/article/7c17f60afc49461995adda03084f6bcb
Autor:
Adam E. Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The influence of mRNA splicing on colon cancer development and progression is unclear. In this study, the authors demonstrate that the SRSF1 splicing factor is essential to sustain the stem cell phenotype of WNT-activated colorectal cancers.
Externí odkaz:
https://doaj.org/article/b084ea4f47254a91b5543e19fe89996c
Autor:
P. G. Vaughan-Shaw, G. Grimes, J. P. Blackmur, M. Timofeeva, M. Walker, L. Y. Ooi, Victoria Svinti, Kevin Donnelly, F. V. N. Din, S. M. Farrington, M. G. Dunlop
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background The risk for several common cancers is influenced by the transcriptomic landscape of the respective tissue-of-origin. Vitamin D influences in vitro gene expression and cancer cell growth. We sought to determine whether oral vitami
Externí odkaz:
https://doaj.org/article/fc43645c66fa44bf9cfadeb6fca36573
Autor:
Susan Martin, Jessica Tyrrell, E Louise Thomas, Matthew J Bown, Andrew R Wood, Robin N Beaumont, Lam C Tsoi, Philip E Stuart, James T Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc Gunter, Caroline Bull, Joshua A Bell, Emma E Vincent, Naveed Sattar, Malcolm G Dunlop, Ian PM Tomlinson, Sara Lindström, INVENT consortium, Jimmy D Bell, Timothy Frayling, Hanieh Yaghootkar
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/40b858df13344706935722cd933d8d45
Autor:
Wei Xu, Yazhou He, Yuming Wang, Xue Li, Jane Young, John P. A. Ioannidis, Malcolm G. Dunlop, Evropi Theodoratou
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-19 (2020)
Abstract Background There is a clear need for systematic appraisal of models/factors predicting colorectal cancer (CRC) metastasis and recurrence because clinical decisions about adjuvant treatment are taken on the basis of such variables. Methods We
Externí odkaz:
https://doaj.org/article/85b78aec76604d5ea6995ff765a925f0
Autor:
James P. Blackmur, Peter G. Vaughan-Shaw, Kevin Donnelly, Bradley T. Harris, Victoria Svinti, Anna-Maria Ochocka-Fox, Paz Freile, Marion Walker, Toby Gurran, Stuart Reid, Colin A. Semple, Farhat V. N. Din, Maria Timofeeva, Malcolm G. Dunlop, Susan M. Farrington
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Colorectal cancer (CRC) is a common, multifactorial disease. While observational studies have identified an association between lower vitamin D and higher CRC risk, supplementation trials have been inconclusive and the mechanisms by which vitamin D m
Externí odkaz:
https://doaj.org/article/686e8d86035a450290be3bc78efa9387
Autor:
Susan Martin, Jessica Tyrrell, E Louise Thomas, Matthew J Bown, Andrew R Wood, Robin N Beaumont, Lam C Tsoi, Philip E Stuart, James T Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc J Gunter, Caroline J Bull, Joshua A Bell, Emma E Vincent, Naveed Sattar, Malcolm G Dunlop, Ian PM Tomlinson, Sara Lindström, INVENT consortium, Jimmy D Bell, Timothy M Frayling, Hanieh Yaghootkar
Publikováno v:
eLife, Vol 11 (2022)
Background: Some individuals living with obesity may be relatively metabolically healthy, whilst others suffer from multiple conditions that may be linked to adverse metabolic effects or other factors. The extent to which the adverse metabolic compon
Externí odkaz:
https://doaj.org/article/6ad55c6d14b64beb84bf87baac62a5be
Autor:
Vitali Goriainov, BM, FRCS(Orth), Msc, PhD, Leonard J. King, MB, ChB, FRCP, FRCR, Richard O.C. Oreffo, DPhil, DSc(Oxon), FHEA, CBiol, FRSB, FIOR, Douglas G. Dunlop, MBBCh, FRCS, FRCSEd(TR&Orth), MD
Publikováno v:
JBJS Open Access, Vol 6, Iss 4 (2021)
Background:. Treatment of massive acetabular defects, both with and without pelvic discontinuity, is challenging. The implants utilized in the surgical procedure need to be stable and integrate with poor host bone stock. In the present study, we desc
Externí odkaz:
https://doaj.org/article/0f9923300b9043e6bce49f337cb40b3e
Autor:
Anja Thormann, Mihail Halachev, William McLaren, David J. Moore, Victoria Svinti, Archie Campbell, Shona M. Kerr, Marc Tischkowitz, Sarah E. Hunt, Malcolm G. Dunlop, Matthew E. Hurles, Caroline F. Wright, Helen V. Firth, Fiona Cunningham, David R. FitzPatrick
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Diagnostic filtering is an important step to analyze the functional and clinical significance of the large number of genetic variants identified from next-generation genome sequencing data. Here, the authors develop a flexible and scalable system for
Externí odkaz:
https://doaj.org/article/ccd9321a1f9b4997aca42718d842068e