Zobrazeno 1 - 5
of 5
pro vyhledávání: '"G. Douglas Ponsler"'
Autor:
Eric T. Williams, Steven A. Wrighton, G. Douglas Ponsler, Everett J. Perkins, Nagy A. Farid, Shane M. Lowery, Miho Kazui, Kenneth J. Ruterbories, Karen O. Jones
Publikováno v:
Drug Metabolism and Disposition. 36:1227-1232
2-Acetoxy-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (prasugrel) is a novel thienopyridine prodrug with demonstrated inhibition of platelet aggregation and activation. The biotransformation of prasugrel to it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff59ad6def7f2963e62109027633aba
https://doi.org/10.1124/dmd.107.020248
https://doi.org/10.1124/dmd.107.020248
Autor:
Amanda J. Long, Jennifer Witcher, Edward L. Mattiuz, John-Michael Sauer, Holly R. Thomasson, Karl A. Desante, G. Douglas Ponsler
Publikováno v:
Drug Metabolism and Disposition. 31:98-107
The role of the polymorphic cytochrome p450 2D6 (CYP2D6) in the pharmacokinetics of atomoxetine hydrochloride [(-)-N-methyl-gamma-(2-methylphenoxy)benzenepropanamine hydrochloride; LY139603] has been documented following both single and multiple dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9637f5478fba6df030f42b65abba078a
https://doi.org/10.1124/dmd.31.1.98
https://doi.org/10.1124/dmd.31.1.98
Publikováno v:
Toxicologic Pathology. 20:155-168
Cephaloridine (Cld) is a nephrotoxic cephalosporin antibiotic. The intracellular biochemical changes that occur leading to Cld-induced nephrotoxicity may involve lipid peroxidation and/or mitochondrial injury. The purpose of this report was to examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc216fd0e9a313019f5a594d1f3489f
https://doi.org/10.1177/019262339202000203
https://doi.org/10.1177/019262339202000203
Autor:
John-Michael Sauer, Paul G. Wood, John H. Mullen, Richard L. Shugert, Edward L. Mattiuz, Robert J. Barbuch, Fengjiun Kuo, G. Douglas Ponsler, Preston C. Conrad, Qimin Li, William J. Wheeler
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 31(1)
These studies were designed to characterize the disposition and metabolism of atomoxetine hydrochloride [(−)- N -methyl-γ-(2-methylphenoxy)benzenepropanamine hydrochloride; formerly know as tomoxetine hydrochloride] in Fischer 344 rats and beagle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414f99dc98728eee8596984d506325ce
https://pubmed.ncbi.nlm.nih.gov/12485957
https://pubmed.ncbi.nlm.nih.gov/12485957
Autor:
Glenn F. Rush, G. Douglas Ponsler
Publikováno v:
Toxicology Letters. 53:215-217
It is well established that cephaloridine (CLD) can cause renal dysfunction, characterized by decreased glomerular filtration rate, glycosuria, enzymuria and proteinuria in both humans and laboratory animals. These changes are often accompanied histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c67e3bf39b9fa0d146089fa83b90fc4
https://doi.org/10.1016/0378-4274(90)90130-e
https://doi.org/10.1016/0378-4274(90)90130-e