Zobrazeno 1 - 10
of 31
pro vyhledávání: '"G. Destefano"'
Autor:
Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renée F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao, Peter C. Searson
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport, and express specialized trans
Externí odkaz:
https://doaj.org/article/15afde94b0a94a09910c567e9da7cd9c
Publikováno v:
Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract The blood–brain barrier (BBB) plays a key role in regulating transport into and out of the brain. With increasing interest in the role of the BBB in health and disease, there have been significant advances in the development of in vitro mo
Externí odkaz:
https://doaj.org/article/a9c166187e864dbe906762e5270a070f
Publikováno v:
Fluids and Barriers of the CNS, Vol 14, Iss 1, Pp 1-15 (2017)
Abstract Background The endothelial cells that form the lumen of capillaries and microvessels are an important component of the blood–brain barrier. Cell phenotype is regulated by transducing a range of biomechanical and biochemical signals in the
Externí odkaz:
https://doaj.org/article/ba56c585bea84532be5b6d1ff45f5e49
Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels
Publikováno v:
J Cereb Blood Flow Metab
The metabolic demands of the brain are met by oxygen and glucose, supplied by a complex hierarchical network of microvessels (arterioles, capillaries, and venules). Transient changes in neural activity are accommodated by local dilation of arterioles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47dbb02948418a9ce68ea24b995f7020
https://doi.org/10.1177/0271678x19855875
https://doi.org/10.1177/0271678x19855875
Autor:
Kalina Hristova, Chengyan Chu, Peter C. Searson, Raleigh M. Linville, Alexander Komin, Jackson G. DeStefano, Xiaoyan Lan, Guanshu Liu, Piotr Walczak
The blood-brain barrier (BBB) tightly controls entry of molecules and cells into the brain, restricting the delivery of therapeutics. Blood-brain barrier opening (BBBO) utilizes reversible disruption of cell-cell junctions between brain microvascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b5b58b14d6fddc66901eae75046a87
https://doi.org/10.1101/2021.02.09.430012
https://doi.org/10.1101/2021.02.09.430012
Autor:
Vasiliki Mahairaki, Peter C. Searson, Linzhao Cheng, Katharine A. Whartenby, Piotr Walczak, Peter A. Calabresi, Chengyan Chu, Max I. Bogorad, Zinnia S. Xu, Alanna M. Farrell, Raleigh M. Linville, Jackson G. DeStefano, Matt B. Sklar
Publikováno v:
Biomaterials. :24-37
Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major component of the BBB, express tight junctions and efflux transporters which regulate paracellular a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a1e684ac6a932d9478f1f68844734d
https://doi.org/10.1016/j.biomaterials.2018.10.023
https://doi.org/10.1016/j.biomaterials.2018.10.023
Autor:
Peter C. Searson, Jackson G. DeStefano, Kalina Hristova, Piotr Walczak, Raleigh M. Linville, Chengyan Chu, Guanshu Liu, Xiaoyan Lan, Alexander Komin
Publikováno v:
Biomaterials
The blood-brain barrier (BBB) tightly controls entry of molecules and cells into the brain, restricting the delivery of therapeutics. Blood-brain barrier opening (BBBO) utilizes reversible disruption of cell-cell junctions between brain microvascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3ffb82111f0208d2aa5676e43620ff
https://doi.org/10.1016/j.biomaterials.2021.120942
https://doi.org/10.1016/j.biomaterials.2021.120942
Autor:
Alexa Wnorowski, Jackson G. DeStefano, Ashley J. Williams, Nahom Yimam, Peter C. Searson, Andrew D. Wong
Publikováno v:
Integrative Biology. 9:362-374
Quiescence is commonly used to describe the inactive state of endothelial cells (ECs) in monolayers that have reached homeostasis. Experimentally quiescence is usually described in terms of the relative change in cell activity (e.g. turnover, speed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0172e1651f8f91941851cd594410fc03
https://doi.org/10.1039/c7ib00023e
https://doi.org/10.1039/c7ib00023e
Publikováno v:
Microvascular Research. 99:8-18
Endothelial cells in straight sections of vessels are known to elongate and align in the direction of flow. This phenotype has been replicated in confluent monolayers of bovine aortic endothelial cells and human umbilical cord endothelial vein cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572d159a84bdf33c691390a9c0924d96
https://doi.org/10.1016/j.mvr.2015.02.008
https://doi.org/10.1016/j.mvr.2015.02.008
Autor:
Max I. Bogorad, Sharon Gerecht, Andrew D. Wong, Peter C. Searson, Johan Karlsson, Jackson G. DeStefano
Publikováno v:
Lab Chip
A wide range of perfusable microvessel models have been developed, exploiting advances in microfabrication, microfluidics, biomaterials, stem cell technology, and tissue engineering. These models vary in complexity and physiological relevance, but pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf3a78830ddb1a98a8c31d5564275bc
https://doi.org/10.1039/c5lc00832h
https://doi.org/10.1039/c5lc00832h