Zobrazeno 1 - 10 of 440 pro vyhledávání: '"G. Dent"'
1
Akademický článek
Actin networks modulate heterogeneous NF-κB dynamics in response to TNFα
Autor: Francesca Butera, Julia E Sero, Lucas G Dent, Chris Bakal
Publikováno v: eLife, Vol 13 (2024)
The canonical NF-κB transcription factor RELA is a master regulator of immune and stress responses and is upregulated in pancreatic ductal adenocardinoma (PDAC) tumours. In this study, we characterised previously unexplored endogenous RELA-GFP dynam
Externí odkaz: https://doaj.org/article/026c08f779a245469dc5d95cd359a962
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2
Akademický článek
Xiphactinus vetus and the Distribution of Xiphactinus Species in the Eastern United States
Autor: Schwimmer, David R., Stewart, J. D., Williams, G. Dent
Publikováno v: Journal of Vertebrate Paleontology, 1997 Sep 01. 17(3), 610-615.
Externí odkaz: https://www.jstor.org/stable/4523841
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4
Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab
Autor: C. Mallinckrodt, Y. Tian, P.S. Aisen, F. Barkhof, S. Cohen, G. Dent, O. Hansson, K. Harrison, T. Iwatsubo, C.J. Mummery, K.K. Muralidharan, I. Nestorov, L. Nisenbaum, R. Rajagovindan, C. von Hehn, C.H. van Dyck, B. Vellas, S. Wu, Y. Zhu, A. Sandrock, T. Chen, S. Budd Haeberlein
Publikováno v: Mallinckrodt, C, Tian, Y, Aisen, P S, Barkhof, F, Cohen, S, Dent, G, Hansson, O, Harrison, K, Iwatsubo, T, Mummery, C J, Muralidharan, K K, Nestorov, I, Nisenbaum, L, Rajagovindan, R, von Hehn, C, van Dyck, C H, Vellas, B, Wu, S, Zhu, Y, Sandrock, A, Chen, T & Budd Haeberlein, S 2023, ' Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab ', Journal of Prevention of Alzheimer's Disease, vol. 10, no. 2, pp. 171-177 . https://doi.org/10.14283/jpad.2023.6
Journal of Prevention of Alzheimer's Disease, 10(2), 171-177. Springer International Publishing AG
Objectives: Efficacy and safety results from the EMERGE (NCT02484547) and ENGAGE (NCT02477800) phase 3 studies of aducanumab in early Alzheimer’s disease (AD) have been published. In EMERGE, but not in ENGAGE, high-dose aducanumab demonstrated sign
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd07dbe73e27c792379e4f551475c168
https://research.vumc.nl/en/publications/18353bb7-a328-4866-843c-42c58403e679
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6
Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer’s Disease
Autor: S. Budd Haeberlein, P.S. Aisen, F. Barkhof, S. Chalkias, T. Chen, S. Cohen, G. Dent, O. Hansson, K. Harrison, C. von Hehn, T. Iwatsubo, C. Mallinckrodt, C.J. Mummery, K.K. Muralidharan, I. Nestorov, L. Nisenbaum, R. Rajagovindan, L. Skordos, Y. Tian, C.H. van Dyck, B. Vellas, S. Wu, Y. Zhu, A. Sandrock
Publikováno v: Journal of Prevention of Alzheimer's Disease, 9(2), 197-210. Springer International Publishing AG
Budd Haeberlein, S, Aisen, P S, Barkhof, F, Chalkias, S, Chen, T, Cohen, S, Dent, G, Hansson, O, Harrison, K, von Hehn, C, Iwatsubo, T, Mallinckrodt, C, Mummery, C J, Muralidharan, K K, Nestorov, I, Nisenbaum, L, Rajagovindan, R, Skordos, L, Tian, Y, van Dyck, C H, Vellas, B, Wu, S, Zhu, Y & Sandrock, A 2022, ' Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer’s Disease ', Journal of Prevention of Alzheimer's Disease, vol. 9, no. 2, pp. 197-210 . https://doi.org/10.14283/jpad.2022.30
Background: Alzheimer’s disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in pathogenesis. Aducanumab is a human monoclonal antibody directed against aggregated soluble an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25356f937683da76b27d9eec33c332a0
https://research.vumc.nl/en/publications/104cb695-ffcb-4502-aba8-9ab998dcbd40
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7
Actin networks modulate heterogenous NF-κB dynamics in response to TNFα
Autor: Francesca Butera, Julia E. Sero, Lucas G. Dent, Chris Bakal
The canonical NF-κB transcription factor RELA is a master regulator of immune and stress responses and is upregulated in PDAC tumours. Here, we characterised previously unknown endogenous RELA-GFP dynamics in PDAC cell lines by live single cell imag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7ea02b6878e6423ced5e817e2c20f5e
https://doi.org/10.1101/2022.01.19.476961
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8
Environmentally dependent and independent control of cell shape determination by Rho GTPase regulators in melanoma
Autor: Chris Bakal, Vincent Maioli, Nathan Curry, Hugh Sparks, Lucas G. Dent, Vicky Bousgouni, Christopher Dunsby, Ian Munro, Sunil Kumar
In order to invade 3D tissues, cancer cells dynamically change cell morphology in response to geometric and mechanical cues in the environment. But how cells determine their shape in 3D versus 2D environments is poorly understood. Studying 2D versus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4407ea2d84a258d9ba145292bda54f50
https://doi.org/10.1101/2021.10.11.463377
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10
Oblique plane microscope plate reader for time lapse 3D imaging of live cells in collagen (Conference Presentation)
Autor: Vincent Maioli, Chris Bakal, Vicky Bousgouni, Sunil Kumar, Lucas G. Dent, Hugh Sparks, Nathan Curry, Ranjeet Kumar, Christopher Dunsby
Publikováno v: Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVIII.
Light sheet fluorescence microscopy (LSFM) enables fast 3D imaging of live cells, however the traditional LSFM geometry is not compatible with conventional multiwell plates used in high content microscopy. We have developed an automated LSFM platerea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b45d3faee6a4f5ce97fec099b5de42a6
https://doi.org/10.1117/12.2542691
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