Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model

Autor: Madhulika Dixit, Jaganathan Kowshik, Kumaraswamy Anbarasu, Siddavaram Nagini, Sundarasamy Mahalingam, Satabdi Rautray, G. Deepak Reddy, Rajakishore Mishra, Josephraj Sophia

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a potent inhibitor of matrix metalloproteinases (MMPs) is a common negative target of oncogenic signals and a potential therapeutic target for novel drug development. Here, we show th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3185cb305c364992ff519292fc6b1924
https://doi.org/10.1038/s41598-017-01960-5

Chemosensitizing acridones: In vitro calmodulin dependent cAMP phosphodiesterase inhibition, docking, pharmacophore modeling and 3D QSAR studies

Autor: G. Deepak Reddy, G.J. Peters, V.V.S. Rajendra Prasad, Y.C. Mayur, D. Appaji

Publikováno v: Journal of Molecular Graphics and Modelling, 40, 116-124. Elsevier Inc.
Prasad, V V S R, Reddy, G D, Appaji, D, Peters, G J & Mayur, Y C 2013, ' Chemosensitizing acridones: In vitro calmodulin dependent cAMP phosphodiesterase inhibition, docking, pharmacophore modeling and 3D QSAR studies ', Journal of Molecular Graphics and Modelling, vol. 40, pp. 116-124 . https://doi.org/10.1016/j.jmgm.2012.12.009

Calmodulin inhibitors have proved to play a significant role in sensitizing MDR cancer cells by interfering with cellular drug accumulation. The present investigation focuses on the evaluation of in vitro inhibitory efficacy of chloro acridones again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab185c70559d50778cae3db589597f4
https://research.vumc.nl/en/publications/45a6cd88-4562-4b67-9d56-efeb18105b47

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Astaxanthin inhibits JAK/STAT-3 signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model of oral cancer.

Autor: J Kowshik, Abdul Basit Baba, Hemant Giri, G Deepak Reddy, Madhulika Dixit, Siddavaram Nagini

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109114 (2014)

Identifying agents that inhibit STAT-3, a cytosolic transcription factor involved in the activation of various genes implicated in tumour progression is a promising strategy for cancer chemoprevention. In the present study, we investigated the effect

Externí odkaz: https://doaj.org/article/b2b028d55ce040158962ab36deafbc76