Výsledky vyhledávání

Akademický článek

Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection

Autor: Alisha Chetty, Matthew G. Darby, Jamie Pillaye, A'ishah Taliep, Adam F. Cunningham, Matthew K. O’Shea, Gnatoulma Katawa, Laura E. Layland, Manuel Ritter, William G. C. Horsnell

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Helminth-induced eosinophils accumulate around the parasite at the site of infection, or in parasite-damaged tissues well after the helminth has left the site. The role of helminth-elicited eosinophils in mediating parasite control is complex. While

Externí odkaz: https://doaj.org/article/ade0fccd93ea42fbab06b16905afa653

Zobrazit plný text záznamu

Akademický článek

Cx3cr1 controls kidney resident macrophage heterogeneity

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Kidney macrophages are comprised of both monocyte-derived and tissue resident populations; however, the heterogeneity of kidney macrophages and factors that regulate their heterogeneity are poorly understood. Herein, we performed single cell RNA sequ

Externí odkaz: https://doaj.org/article/33bd5d09e8bc4889bac131cdfd30c35a

Zobrazit plný text záznamu

Akademický článek

Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4

Autor: Katherine Griffiths, Uli Binder, William McDowell, Rita Tommasi, Mark Frigerio, William G. Darby, Chris G. Hosking, Lionel Renaud, Matthias Machacek, Peter Lloyd, Arne Skerra, Michael Foley

Publikováno v: mAbs, Vol 11, Iss 7, Pp 1331-1340 (2019)

Single domain antibodies that combine antigen specificity with high tissue penetration are an attractive alternative to conventional antibodies. However, rapid clearance from the bloodstream owing to their small size can be a limitation of therapeuti

Externí odkaz: https://doaj.org/article/7654a6ff13a34f68ab979ca90ac88158

Zobrazit plný text záznamu

Akademický článek

Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity

Autor: Donald D. Nyangahu, Katie S. Lennard, Bryan P. Brown, Matthew G. Darby, Jerome M. Wendoh, Enock Havyarimana, Peter Smith, James Butcher, Alain Stintzi, Nicola Mulder, William Horsnell, Heather B. Jaspan

Publikováno v: Microbiome, Vol 6, Iss 1, Pp 1-10 (2018)

Abstract Background Early life microbiota is an important determinant of immune and metabolic development and may have lasting consequences. The maternal gut microbiota during pregnancy or breastfeeding is important for defining infant gut microbiota

Externí odkaz: https://doaj.org/article/d52451c839324486ba579da7273ca4c4

Zobrazit plný text záznamu

Akademický článek

The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels

Autor: Sara Baratchi, Peter Keov, William G. Darby, Austin Lai, Khashayar Khoshmanesh, Peter Thurgood, Parisa Vahidi, Karin Ejendal, Peter McIntyre

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

TRPV4 is a non-selective cation channel that tunes the function of different tissues including the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective and potent agonist of TRPV4 and a pharmacological tool that is used

Externí odkaz: https://doaj.org/article/d32593cbbda246a08316fc463d02fa30

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání