Zobrazeno 1 - 10
of 25
pro vyhledávání: '"G. D. Schellenberg"'
Autor:
A. R. Borenstein, J. A. Mortimer, G. D. Schellenberg, D. Galasko, W. G. Bradley, S. Anne Banack, P. Alan Cox, R. Cruz-Aguado, C. A. Shaw, P. S. Spencer, V. Palmer, G. Kisby, P. L. McGeer, J. C. Steele
Publikováno v:
Neurology. 72:473-476
There is a high incidence on Guam of a severe tauopathy known as the Parkinson- dementia complex (PDC). It is linked with an even more malignant amyotrophic lateral sclerosis (ALS) syndrome. There is great interest in determining the cause, or causes
Autor:
P, Poorkaj, J G, Nutt, D, James, S, Gancher, T D, Bird, E, Steinbart, G D, Schellenberg, Haydeh, Payami
Publikováno v:
American journal of medical genetics. Part A. (1)
parkin Mutations are the most common identified cause of Parkinson's disease (PD). It has been suggested that patients with young-onset PD be screened for parkin mutations as a part of their clinical work-up. The aim of this study was to assess parki
Autor:
D W, Tsuang, A D, Skol, S V, Faraone, S, Bingham, K A, Young, S, Prabhudesai, S L, Haverstock, F, Mena, A S, Menon, D, Bisset, J, Pepple, F, Sauter, C, Baldwin, D, Weiss, J, Collins, M, Boehnke, G D, Schellenberg, M T, Tsuang
Publikováno v:
American journal of medical genetics. 105(8)
Previous studies have reported genetic linkage evidence for a schizophrenia gene on chromosome 15q. Here, chromosome 15 was examined by genetic linkage analysis using 166 schizophrenia families, each with two or more affected subjects. The families,
Publikováno v:
Journal of neuroscience research. 52(5)
Mutations in the presenilin-1 (PS-1) gene are responsible for many cases of autosomal dominant early-onset inherited Alzheimer's disease (AD). PS-1 is expressed in neurons where it is localized primarily to the endoplasmic reticulum (ER); the normal
Autor:
E R, Peskind, J, Leverenz, M R, Farlow, R K, Ito, S A, Provow, R S, Siegel, M, Cleveland, C H, Morgan, M R, Pandian, S, Corbin, D, Nochlin, G D, Schellenberg, M A, Raskind, S L, Wagner
Publikováno v:
Alzheimer disease and associated disorders. 11(4)
The authors compared concentrations of soluble beta-amyloid protein precursor (s beta PP) in cerebrospinal fluid (CSF) in 45 patients diagnosed with probable Alzheimer disease (AD) and 26 normal older control volunteers. Soluble beta-amyloid protein
Autor:
C E, Yu, J, Oshima, E M, Wijsman, J, Nakura, T, Miki, C, Piussan, S, Matthews, Y H, Fu, J, Mulligan, G M, Martin, G D, Schellenberg
Publikováno v:
American journal of human genetics. 60(2)
Werner syndrome (WS) is an autosomal recessive disease with a complex phenotype that is suggestive of accelerated aging. WS is caused by mutations in a gene, WRN, that encodes a predicted 1,432-amino-acid protein with homology to DNA and RNA helicase
Autor:
J, Oshima, G D, Schellenberg
Publikováno v:
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 41(10)
Autor:
K A, Goddard, C E, Yu, J, Oshima, T, Miki, J, Nakura, C, Piussan, G M, Martin, G D, Schellenberg, E M, Wijsman
Publikováno v:
American journal of human genetics. 58(6)
Werner syndrome (WS) is an autosomal recessive disorder characterized by premature onset of a number of age-related diseases. The gene for WS, WRN, has been mapped to the 8p 11.1-21.1 region with further localization through linkage disequilibrium ma
Autor:
H, Payami, S, Zareparsi, K R, Montee, G J, Sexton, J A, Kaye, T D, Bird, C E, Yu, E M, Wijsman, L L, Heston, M, Litt, G D, Schellenberg
Publikováno v:
American journal of human genetics. 58(4)
Late-onset Alzheimer disease (AD) is associated with the apolipoprotein E (APOE)-epsilon4 allele. In late-onset familial AD, women have a significantly higher risk of developing the disease than do men. The aim of this study was to determine whether
Autor:
G D, Schellenberg
Publikováno v:
Arzneimittel-Forschung. 45(3A)
Defective genes play an important role in some, if not all cases of Alzheimer's disease (AD). Epidemiologic case control studies, family pedigree analysis, and recent twin studies clearly implicate inherited gene defects in development of the disease