Výsledky vyhledávání

Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors

Autor: G. Cruzan, J. Bus, J. Hotchkiss, R. Sura, C. Moore, G. Yost, M. Banton, S. Sarang

Publikováno v: Regulatory Toxicology and Pharmacology. 66:24-29

Styrene (S) is lung tumorigenic in mice but not in rats. S and its alkene-oxidized metabolite styrene oxide (SO) were not lung toxic in CYP2F2(-/-) [knockout] mice, indicating S-induced mouse lung tumors are mediated through mouse-specific CYP2F2-gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8486b08a8456b08680161a63038b657c
https://doi.org/10.1016/j.yrtph.2013.02.008

Zobrazit plný text záznamu

Assessment in rats of the reproductive toxicity of gasoline from a gasoline vapor recovery unit

Autor: Gary W. Trimmer, F.T. Whitman, C.S. Nessel, Randi Hagemann, B.J. Simpson, Richard H. McKee, G. Cruzan, J.H. Urbanus, Robert A.J. Priston, C.R. Mackerer, A.J. Riley

Publikováno v: Reproductive Toxicology. 14:337-353

Gasoline (CAS 86290-81-5) is one of the world's largest volume commercial products. Although numerous toxicology studies have been conducted, the potential for reproductive toxicity has not been directly assessed. Accordingly, a two-generation reprod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711b7d271d86c12cfe9181d0d9e30674
https://doi.org/10.1016/s0890-6238(00)00085-x

Zobrazit plný text záznamu

Ecotoxicity Hazard Assessment of Styrene

Autor: J.V. Sousa, G. Cruzan, Arthur E. Putt, M.W. Machado, J.R. Hoberg, N.A. Garvey, J.R. Cushman, J.P. St. Laurent, E. Williams, M.C. Harrass, G.A. Rausina, J. Gilbert

Publikováno v: Ecotoxicology and Environmental Safety. 37:173-180

The ecotoxicity of styrene was evaluated in acute toxicity studies of fathead minnows (Pimephales promelas), daphnids (Daphnia magna), amphipods (Hyalella azteca), and freshwater green algae (Selenastrum capricornutum), and a subacute toxicity study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d78239ac434dc9fd8e458e98eef8c3
https://doi.org/10.1006/eesa.1997.1540

Zobrazit plný text záznamu

CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors

Autor: G. Cruzan, J. Bus, J. Hotchkiss, J. Harkema, M. Banton, S. Sarang

Publikováno v: Regulatory toxicology and pharmacology : RTP. 62(1)

Styrene induces lung tumors in mice but not in rats. Although metabolism of styrene to 7,8-styrene oxide (SO) by CYP2E1 has been suggested as a mediator of styrene toxicity, lung toxicity is not attenuated in CYP2E1 knockout mice. However, styrene an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce6f0391d53edf1e8dd6d3f0bf6bfe1
https://pubmed.ncbi.nlm.nih.gov/22041433

Zobrazit plný text záznamu

The mutagenicity testing of tertiary-butyl alcohol, tertiary-butyl acetate and methyl tertiary-butyl ether in Salmonella typhimurium

Autor: Marcy I. Banton, G. Cruzan, D.B. McGregor, R.D. Callander, K. May

Publikováno v: Mutation research. 565(2)

Tertiary -Butyl alcohol (TBA), tertiary -butyl acetate™ (TBAc™) and methyl tertiary -butyl ether (MTBE) are chemicals to which the general public may be exposed either directly or as a result of their metabolism. There is little evidence that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a982fc6f80d938f2af789e5a3b787f
https://pubmed.ncbi.nlm.nih.gov/15661616

Zobrazit plný text záznamu

Chronic toxicity/oncogenicity study of styrene in CD rats by inhalation exposure for 104 weeks

Autor: G, Cruzan, J R, Cushman, L S, Andrews, G C, Granville, K A, Johnson, C J, Hardy, D W, Coombs, P A, Mullins, W R, Brown

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 46(2)

Groups of 70 male and 70 female Charles River CD (Sprague-Dawley-derived) rats were exposed whole body to styrene vapor at 0, 50, 200, 500, or 1000 ppm 6 h/day 5 days/week for 104 weeks. The rats were observed daily, body weights and food and water c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b8639f547a3b9be3dbf75a8d7ebe4169
https://pubmed.ncbi.nlm.nih.gov/10048130

Zobrazit plný text záznamu

A comprehensive evaluation of the mechanism of skin tumorigenesis by straight-run and cracked petroleum middle distillates

Autor: C S, Nessel, R A, Priston, R H, McKee, G, Cruzan, A J, Riley, R, Hagemann, R T, Plutnick, B J, Simpson

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 44(1)

The role of skin irritation and other factors on the tumorigenic activity of petroleum middle distillates (PMDs) in mice was examined in a comprehensive research program. The program culminated in a 2-year dermal carcinogenicity study which compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::742dabe65988adbf14cbeb9fab5d017b
https://pubmed.ncbi.nlm.nih.gov/9720137

Zobrazit plný text záznamu

Cuprous‐Cupric Oxide Films on Copper

Autor: C. G. Cruzan, H. A. Miley

Publikováno v: Journal of Applied Physics. 11:631-634

The influence of film thickness on the formation of cupric oxide in cuprous oxide films on an abraded copper surface was studied from measurements obtained by the electrolytic reduction method. The critical thickness value for the formation of cupric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15440f2b82110144982aa45d650d01a7
https://doi.org/10.1063/1.1712714

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání