Zobrazeno 1 - 10
of 101
pro vyhledávání: '"G. Claeson"'
Autor:
Rainer Metternich, S R Stone, C Tapparelli, Michael F. Scully, C Ehrhardt, M Zurini, G. Claeson
Publikováno v:
Journal of Biological Chemistry. 268:4734-4741
Peptide boronic acid derivatives have proven to be very potent inhibitors of serine proteases with boroarginine derivatives being particularly potent thrombin inhibitors. The importance of the charged side chain of arginine has been investigated by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f96b4f8eba2118f8eef79a013724214
https://doi.org/10.1016/s0021-9258(18)53458-x
https://doi.org/10.1016/s0021-9258(18)53458-x
Autor:
G, Claeson
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 5(3)
The synthesis of peptides as imitations of the thrombin cleavage site of fibrinogen has led to sequences with affinity for the enzyme. These peptides were first developed as chromogenic and fluorogenic substrates for thrombin. The same idea was also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d06370046b57c5cccef9657549d3ae06
https://pubmed.ncbi.nlm.nih.gov/8075312
https://pubmed.ncbi.nlm.nih.gov/8075312
Publikováno v:
The Journal of biological chemistry. 268(7)
Peptide boronic acid derivatives have proven to be very potent inhibitors of serine proteases with boroarginine derivatives being particularly potent thrombin inhibitors. The importance of the charged side chain of arginine has been investigated by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::413a9ee608ab092edf663e09404428bd
https://pubmed.ncbi.nlm.nih.gov/8444849
https://pubmed.ncbi.nlm.nih.gov/8444849
Autor:
E. Agner, Ling-Hao Niu, T. Desoyza, Vijay V. Kakkar, Michael F. Scully, Rainer Metternich, Manfred Philipp, G. Claeson
Publikováno v:
The Biochemical journal. 290
Thrombin, the blood-clotting enzyme, is a serine proteinase with trypsin-like specificity and is able to cleave Arg-Xaa peptide bonds but only in a very limited number of substrates (and sites therein). For the prevention and treatment of thrombosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8144350fff57e0a496860dd9bfe4c27a
https://pubmed.ncbi.nlm.nih.gov/8452516
https://pubmed.ncbi.nlm.nih.gov/8452516
Publikováno v:
Advances in experimental medicine and biology. 340
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cac98db5f65f6a627b3705061edc8320
https://pubmed.ncbi.nlm.nih.gov/8154344
https://pubmed.ncbi.nlm.nih.gov/8154344
Publikováno v:
Advances in experimental medicine and biology. 340
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11a418e7e785594d82aa7747d09c219b
https://pubmed.ncbi.nlm.nih.gov/8154334
https://pubmed.ncbi.nlm.nih.gov/8154334
Publikováno v:
Advances in experimental medicine and biology. 340
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbc04434ca5468edb851b890efb20583
https://pubmed.ncbi.nlm.nih.gov/8154330
https://pubmed.ncbi.nlm.nih.gov/8154330
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781489924209
In 1956, Bettelheim1 showed that fibrinopeptide A (FPA) competitively inhibits the reaction between thrombin and fibrinogen, that is the amino acid sequence, FPA, preceding the bond split by thrombin has affinity for the enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f91de4df958ca923e0781565765957e8
https://doi.org/10.1007/978-1-4899-2418-6_8
https://doi.org/10.1007/978-1-4899-2418-6_8
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781489924209
Phosphorus-containing inhibitors, such as diisopropyl phosphorofluoride (DFP), are classical inhibitors of serine proteases. These compounds react irreversibly with the active site serine hydroxy group, forming a covalent adduct. Nonpeptidyl phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a97c23be3d3032e805e9472dd1bd6c1
https://doi.org/10.1007/978-1-4899-2418-6_15
https://doi.org/10.1007/978-1-4899-2418-6_15
Publikováno v:
Advances in experimental medicine and biology. 340
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5285dc83185f09f8efd4721fef64388d
https://pubmed.ncbi.nlm.nih.gov/8154346
https://pubmed.ncbi.nlm.nih.gov/8154346