Assessment of various continual reassessment method models for dose-escalation phase 1 oncology clinical trials: using real clinical data and simulation studies

Autor: G. D. James, S. Symeonides, J. Marshall, J. Young, G. Clack

Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)

Abstract Background The continual reassessment method (CRM) identifies the maximum tolerated dose (MTD) more efficiently and identifies the true MTD more frequently compared to standard methods such as the 3 + 3 method. An initial estimate of the dos

Externí odkaz: https://doaj.org/article/1cd763e28cbe4ad7a3a360746c4e8dd0

A platform for brain-wide imaging and reconstruction of individual neurons

Autor: Michael N Economo, Nathan G Clack, Luke D Lavis, Charles R Gerfen, Karel Svoboda, Eugene W Myers, Jayaram Chandrashekar

Publikováno v: eLife, Vol 5 (2016)

The structure of axonal arbors controls how signals from individual neurons are routed within the mammalian brain. However, the arbors of very few long-range projection neurons have been reconstructed in their entirety, as axons with diameters as sma

Externí odkaz: https://doaj.org/article/9de8863688c64e2da58eaaea9e2e5b7f

Automated tracking of whiskers in videos of head fixed rodents.

Autor: Nathan G Clack, Daniel H O'Connor, Daniel Huber, Leopoldo Petreanu, Andrew Hires, Simon Peron, Karel Svoboda, Eugene W Myers

Publikováno v: PLoS Computational Biology, Vol 8, Iss 7, p e1002591 (2012)

We have developed software for fully automated tracking of vibrissae (whiskers) in high-speed videos (>500 Hz) of head-fixed, behaving rodents trimmed to a single row of whiskers. Performance was assessed against a manually curated dataset consisting

Externí odkaz: https://doaj.org/article/fe225544ce464409a1f9ab0993635cf4

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NWB:N 2.0: An Accessible Data Standard for Neurophysiology

Autor: William J. Schroeder, Lydia Ng, Kristofer E. Bouchard, Karel Svoboda, Nile Graddis, Nicholas Cain, Thomas Braun, Justin T. Kiggins, Friedrich T. Sommer, Benjamin Dichter, Max Dougherty, Jean-Christophe Fillion-Robin, Andrew Tritt, Oliver Ruebel, Thomas J. Davidson, Ivan Soltesz, Michael Grauer, Loren M. Frank, Nathan G. Clack, Doruk Ozturk, Lawrence Niu

Publikováno v: Ruebel, Oliver; Tritt, Andrew; Dichter, Benjamin; Braun, Thomas; Cain, Nicholas; Clack, Nathan; et al.(2019). NWB:N 2.0: An Accessible Data Standard for Neurophysiology. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/8582b6x9

Author(s): Rubel, Oliver; Tritt, Andrew; Dichter, Benjamin; Braun, Thomas; Cain, Nicholas; Clack, Nathan; Davidson, Thomas; Dougherty, Max; Fillion-Robin, Jean-Christophe; Graddis, Nile; Grauer, Michael; Kiggins, Justin; Niu, Lawrence; Ozturk, Doruk;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8918e69b6532ba4adb0df6d8c47e6d
https://escholarship.org/uc/item/8582b6x9