Zobrazeno 1 - 10
of 483
pro vyhledávání: '"G. Childs"'
Autor:
Camille Cohen, Océane Le Goff, Frédéric Soysouvanh, Florence Vasseur, Marine Tanou, Clément Nguyen, Lucile Amrouche, Julien Le Guen, Oriana Saltel‐Fulero, Tanguy Meunier, Thao Nguyen‐Khoa, Marion Rabant, Dominique Nochy, Christophe Legendre, Gérard Friedlander, Bennett G Childs, Daren J Baker, Bertrand Knebelmann, Dany Anglicheau, Fabien Milliat, Fabiola Terzi
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-20 (2021)
Abstract The mechanisms underlying the development of glomerular lesions during aging are largely unknown. It has been suggested that senescence might play a role, but the pathophysiological link between senescence and lesion development remains unex
Externí odkaz:
https://doaj.org/article/eff346c772ac4a2782e8d2599fcc5044
Autor:
John W. Kennedy, P. Monica Tsimbouri, Paul Campsie, Shatakshi Sood, Peter G. Childs, Stuart Reid, Peter S. Young, Dominic R. M. Meek, Carl S. Goodyear, Matthew J. Dalby
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Models of bone remodelling could be useful in drug discovery, particularly if the model is one that replicates bone regeneration with reduction in osteoclast activity. Here we use nanovibrational stimulation to achieve this in a 3D co-cultur
Externí odkaz:
https://doaj.org/article/810f83f7a49e40a688c667b930757c1d
Publikováno v:
Nature Cell Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b799a7bdcabab0813621811bf94d6f26
https://doi.org/10.1038/s41556-023-01153-5
https://doi.org/10.1038/s41556-023-01153-5
Autor:
Cheng Zhang, Bennett G. Childs, Hu Li, Raul O. Fierro Velasco, Ines Sturmlechner, Fahad Shuja, Darren J. Baker, Jan M. van Deursen, Shawn Trewartha
Publikováno v:
Nat Aging
Senescent cells (SNCs) degenerate the fibrous cap that normally prevents atherogenic plaque rupture, a leading cause of myocardial infarction and stroke. Here we explore the underlying mechanism using pharmacological or transgenic approaches to clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0d8ad257fc57dd562ce2ab4f4a87be
https://doi.org/10.1038/s43587-021-00089-5
https://doi.org/10.1038/s43587-021-00089-5
Autor:
Alireza Khodadadi-Jamayran, Stephen C. Textor, Timothy B. Niewold, Xiangyang Zhu, Ian Taylor, Amir Lerman, Tamara Tchkonia, Lilach O. Lerman, Xiao Jun Chen, James L. Kirkland, Amrutesh S. Puranik, Seo Rin Kim, La Tonya J. Hickson, Bennett G. Childs, Kai Jiang
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Peripheral vascular diseases may induce chronic ischemia and cellular injury distal to the arterial obstruction. Cellular senescence involves proliferation arrest in response to stress, which can damage neighboring cells. Renal artery ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8cbc6c03831f61d813d9ec36ba1966
https://doi.org/10.1681/asn.2020091373
https://doi.org/10.1681/asn.2020091373
Autor:
Brian A. Davies, Johanna A. Payne, Cole P. Martin, Destiny Schultz, Bennett G. Childs, Cheng Zhang, Karthik Jeganathan, Ines Sturmlechner, Thomas A. White, Alain de Bruin, Huiqin Chen, Michael A. Davies, Sarah Jachim, Nathan K. LeBrasseur, Robert C. Piper, Hu Li, Darren J. Baker, Jan van Deursen, David J. Katzmann
Endosomal Sorting Complexes Required for Transport (ESCRTs) drive reverse topology membrane remodeling events including the formation of intralumenal vesicles within multivesicular bodies, the budding of retroviruses from the plasma membrane, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb5c3cb386817736dfe03b4a5f056e3
https://doi.org/10.1101/2022.08.02.502401
https://doi.org/10.1101/2022.08.02.502401
Akademický článek
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Autor:
Guilherme C. de Oliveira, Tamara Tchkonia, Karthikeyani Chellappa, Karina S. Kanamori, Connor Jankowski, Katie L. Thompson, Guillermo Agorrody, Joshua D. Rabinowitz, Amrutesh S. Puranik, James L. Kirkland, Jan M. van Deursen, Kevin Dang, Gina M. Warner, Claudia C.S. Chini, Micaela A. Witte, Eduardo N. Chini, Lilian S Gomez, Starlynn Clarke, Thais Peclat, Jair Machado Espindola-Netto, Melanie R. McReynolds, Kelly A. Hogan, Marco De Cecco, Wim Van Schooten, Darren J. Baker, Paola Vidal, Bennett G. Childs, Sonu Kashyap, Mariana G. Tarragó, Joseph A. Baur, Anna L. Kirkland, John M. Sedivy
Publikováno v:
Nature metabolism
Decreased nicotinamide adenine dinucleotide (NAD+) levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f293082b523d28c2c49e835f21eb18
http://europepmc.org/articles/PMC8752031
http://europepmc.org/articles/PMC8752031
Publikováno v:
Biochemical Journal
Twenty-five years have passed since the first clinical trial utilising mesenchymal stomal/stem cells (MSCs) in 1995. In this time academic research has grown our understanding of MSC biochemistry and our ability to manipulate these cells in vitro usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780cede7b109f03d6add9bef1d2501c6
https://doi.org/10.1042/bcj20190382
https://doi.org/10.1042/bcj20190382
Autor:
Matthew J. Dalby, Monica P. Tsimbouri, Massimo Vassalli, Manlio Tassieri, Stuart Reid, Manus J.P. Biggs, Peter G. Childs, Marc Mechanical Fernandez, K. Elizabeth Tanner, Wich Orapiriyakul, Manuel Salmerón-Sánchez, Karl Burgess, Dominic Meek, Richard O.C. Oreffo, Julia Wells, Paul Campsie
Publikováno v:
ACS Nano
There is a pressing clinical need to develop cell-based bone therapies due to a lack of viable, autologous bone grafts and a growing demand for bone grafts in musculoskeletal surgery. Such therapies can be tissue engineered and cellular, such as oste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8050dc07ca5089fac6f0bc292dc21683
http://europepmc.org/articles/PMC7458485
http://europepmc.org/articles/PMC7458485