Zobrazeno 1 - 10
of 157
pro vyhledávání: '"G. Campbell Teskey"'
Autor:
Bianca R. Villa, Dhyey Bhatt, Marshal D. Wolff, Kwaku Addo-Osafo, Jonathan R. Epp, G. Campbell Teskey
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Comorbidities during the period between seizures present a significant challenge for individuals with epilepsy. Despite their clinical relevance, the pathophysiology of the interictal symptomatology is largely unknown. Postictal severe hypox
Externí odkaz:
https://doaj.org/article/c1c8361e8030463093a76d1490ae5292
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Sudden unexpected death in epilepsy (SUDEP) is the leading epilepsy-related cause of premature mortality in people with intractable epilepsy, who are 27 times more likely to die than the general population. Impairment of the central control
Externí odkaz:
https://doaj.org/article/83a6b645b38c407fa366f4a129208f31
New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-4 (2022)
Abstract Adult neurogenesis, the proliferation and integration of newly generated neurons, has been observed in the adult mammalian hippocampus of many species. Numerous studies have also found adult neurogenesis in the human hippocampus, but several
Externí odkaz:
https://doaj.org/article/eb7d181611ad42fcbbc4cd92bacd8562
Autor:
Renaud C. Gom, Dhyey Bhatt, Bianca R. Villa, Antis G. George, Alexander W. Lohman, Richelle Mychasiuk, Jong M. Rho, G. Campbell Teskey
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105335- (2021)
Objectives: A prolonged vasoconstriction/hypoperfusion/hypoxic event follows self-terminating focal seizures. The ketogenic diet (KD) has demonstrated efficacy as a metabolic treatment for intractable epilepsy and other disorders but its effect on lo
Externí odkaz:
https://doaj.org/article/160750426e64448285582cddf18a1ed6
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
Seizures can result in a severe hypoperfusion/hypoxic attack that causes postictal memory and behavioral impairments. However, neither postictal changes to microvasculature nor Ca2+ changes in key cell types controlling blood perfusion have been visu
Externí odkaz:
https://doaj.org/article/1887ad402b024477bcbfdef289570e19
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 2, Pp 692-700 (2012)
Introduction: Clinical studies have suggested that children experiencing a febrile seizure (FS) before the age of 1 year have persistent deficits, but it is unknown whether these seizures lead to permanent cortical reorganization and alterations in f
Externí odkaz:
https://doaj.org/article/9eab6a5968e1491fab76a4fb31c8ff41
Publikováno v:
Journal of Neurophysiology. 128:727-737
Repetitive mild traumatic brain injuries (RmTBIs) are increasingly recognized to have long-term neurological sequelae in a significant proportion of patients. Individuals that have had RmTBIs exhibit a variety of sensory, cognitive, or behavioral con
Autor:
Cam Ha T. Tran, G. Campbell Teskey
Publikováno v:
Neuroglia. 2:36-47
Neurovascular coupling is a key control mechanism in cerebral blood flow (CBF) regulation. Importantly, this process was demonstrated to be affected in several neurological disorders, including epilepsy. Neurovascular coupling (NVC) is the basis for
Autor:
Antis G. George, Jordan S. Farrell, Roberto Colangeli, Alexandra K. Wall, Renaud C. Gom, Mitchell T. Kesler, Cristiane Rodriguez de la Hoz, Bianca R. Villa, Tefani Perera, Jong M. Rho, Deborah Kurrasch, G. Campbell Teskey
Publikováno v:
Neuropharmacology. 231:109513
Autor:
Sydney A. Harris, Antis G. George, Karlene T. Barrett, Morris H. Scantlebury, G. Campbell Teskey
Publikováno v:
EpilepsiaREFERENCES. 63(10)
In adult brain tissue, oxygen levels typically remain in the normoxic zone, but status epilepticus results in hyperoxia, whereas brief self-terminating seizures lead to postictal hypoxia. The dynamic changes in oxygen levels and the underlying mechan