Zobrazeno 1 - 10
of 19
pro vyhledávání: '"G. C. Stratmann"'
Publikováno v:
Journal of Neurochemistry. 65:2165-2169
Physostigmine, the acetylcholinesterase inhibitor (0.3 mg/kg, i.m.), increased extracellular glutamate but not aspartate concentrations in the striatum of anaesthetised rats, determined using microdialysis and HPLC. The rise was both tetrodotoxin and
Publikováno v:
British Journal of Pharmacology. 115:1169-1174
1. We have investigated an aspect of the regulation of cortical pyramidal neurone activity. Microdialysis was used to assess whether topical application of drugs (in 10 microliter) to fill a burr hole over the frontal cortex, where part of the cortic
Autor:
A. W. Procter, P. T. Francis, C. Holmes, M-T. Webster, M. Qume, G. C. Stratmann, R. Doshi, D. M. A. Mann, P. J. Harrison, R. C. A. Pearson, D. M. Bowen
Publikováno v:
Acta Neuropathologica. 88:545-552
Post-mortem cerebral cortex from 15 demented patients was specially collected to minimise autolysis and two membrane fractions and one soluble fraction were quantitatively examined for the major species of beta-amyloid precursor protein (APP) of high
Autor:
Andrew W. Procter, M.-T. Webster, David M. Bowen, D. M. A. Mann, Rupak Doshi, Paul T. Francis, G. C. Stratmann
Publikováno v:
Brain Research. 644:347-351
Concentrations of amyloid precursor protein (APP)-like immunoreactivity (APPLIR) have been determined by Western blotting in a soluble fraction and two membrane fractions of two areas of brain cortex from patients with Alzheimer's disease (AD) and ot
Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms
Publikováno v:
Neurochemical Research. 17:917-922
Behavioural symptoms of Alzheimer's disease, such as aggression, may determine the care patients required. Most postmortem neurochemical studies have been of institutionalized patients and conclusions drawn from these may not be valid for all patient
Publikováno v:
Neuroscience Letters. 143:43-47
‘Clipsin’ and other peptide bond hydrolase activities that appear to be integral membrane proteins, including two implicated in the formation of the histological hallmarks of Alzheimer's disease, were assayed in the frontal and parietal cortex fr
Autor:
Clive Holmes, M.-T. Webster, Green Alfred Richard, Alan J. Cross, G. C. Stratmann, David M. Bowen, I.P. Chessell, Paul T. Francis, Andrew W. Procter
Publikováno v:
Annals of the New York Academy of Sciences. 695
A substantial loss of cortical cholinergic nerve endings, along with a much more circumscribed cortical degeneration of pyramidal neurons, almost certainly causes glutamatergic hypoactivity in live Alzheimer's patients. These selective pathologies ar
Autor:
M.-T. Webster, Paul T. Francis, Andrew W. Procter, Clive Holmes, G. C. Stratmann, David M. Bowen
Publikováno v:
Dementia (Basel, Switzerland). 4(3-4)
Non-Alzheimer''s dementia due to lobar atrophy had choline acetyltransferase activities comparable with control rather than Alzheimer''s disease values, based on 3 autopsy proven cases on Pick''s disease and biopsies from 3 examples of dementia of fr
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 261(3)
Experimental lesions followed by binding of [3H]8-hydroxy-2-(n-dipropylamino)tetralin (8-OH-DPAT) and [3H]ketanserin to cryostat sections and quantitative autoradiography were used to investigate the cellular localization of 5-hydroxytryptamine1A (5-
Autor:
Paul T. Francis, S. L. Lowe, Andrew W. Procter, Paulo Henrique Ferreira Bertolucci, G. C. Stratmann, David M. Bowen
Publikováno v:
Journal of neurochemistry. 56(1)
[3H]Glycine binding and glycine modulation of [3H]MK-801 binding have been used to study the glycine allosteric site associated with the N-methyl-D-aspartate receptor complex in postmortem human brain. The effect of glycine on [3H]MK-801 binding appe