Výsledky vyhledávání

The interferon-stimulated genes: targets of direct signaling by interferons, double-stranded RNA, and viruses

Autor: G C, Sen, S N, Sarkar

Publikováno v: Current topics in microbiology and immunology. 316

The interferon system plays a profound role in determining the outcome of viral infection in mammals. Viruses induce the synthesis of interferon, which, in turn, blocks virus replication by inducing the expression of antiviral proteins encoded by int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9a43ef39ff470c16d8c0742165fe52d
https://pubmed.ncbi.nlm.nih.gov/17969451

Zobrazit plný text záznamu

Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis

Autor: M, Chawla-Sarkar, D J, Lindner, Y-F, Liu, B R, Williams, G C, Sen, R H, Silverman, E C, Borden

Publikováno v: Apoptosis : an international journal on programmed cell death. 8(3)

IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of responsive genes. IFNs were the first human proteins to be effective in cancer therapy and were among the first recombinant DNA products to be used clinically. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc1d1a21183449434917d930b6afa0ce
https://pubmed.ncbi.nlm.nih.gov/12766484

Zobrazit plný text záznamu

Species variation in the testicular angiotensin converting enzyme promoter studied in transgenic mice

Autor: R P, Erickson, S, Kessler, H, Kremling, G C, Sen

Publikováno v: Molecular reproduction and development. 44(3)

We have studied the control of transcription of the testicular angiotensin converting enzyme (ACEt) in normal and transgenic mice. Northern analyses, including a developmental curve and separated germ cells, for ACEt mRNA suggest predominantly post-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::228f1053daf062d979e73f9c7425c741
https://pubmed.ncbi.nlm.nih.gov/8858602

Zobrazit plný text záznamu

Transcriptional repression of heterologous constitutive and inducible promoters by the negative element of the rabbit angiotensin-converting enzyme gene

Autor: S P, Kessler, G C, Sen

Publikováno v: Cellularmolecular biology research. 41(6)

We previously identified a transcriptional negative element (NE) present in the rabbit angiotensin-converting enzyme (ACE) gene. Here, we report that the NE can also repress transcription driven by the strong constitutive promoters of the human beta-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccb598c0d64bdb433f0732786d05ccc5
https://pubmed.ncbi.nlm.nih.gov/8777439

Zobrazit plný text záznamu

Role of the amino-terminal residues of the interferon-induced protein kinase in its activation by double-stranded RNA and heparin

Autor: R C, Patel, P, Stanton, G C, Sen

Publikováno v: The Journal of biological chemistry. 269(28)

We have previously reported that the amino-terminal residues 1-34 of the interferon-induced protein kinase (RNA-activated) (PKR) are necessary for its binding to and activation by double-stranded RNA (dsRNA) (Patel, R. C., and Sen, G. C. (1992) J. Bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d40f1c240e50bbc1d0653992c3e7b122
https://pubmed.ncbi.nlm.nih.gov/7518438

Zobrazit plný text záznamu

Regulated cleavage-secretion of the membrane-bound angiotensin-converting enzyme

Autor: R, Ramchandran, G C, Sen, K, Misono, I, Sen

Publikováno v: The Journal of biological chemistry. 269(3)

Angiotensin-converting enzyme (ACE) is an ectoprotein anchored in the plasma membrane through a hydrophobic domain near its carboxyl-terminal region. Mouse epithelial cells transfected with rabbit testicular ACE cDNA, synthesize, glycosylate, and sec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60d336437df4f1feb907fc1fedd1aee7
https://pubmed.ncbi.nlm.nih.gov/8294466

Zobrazit plný text záznamu

Characterization of the interactions between double-stranded RNA and the double-stranded RNA binding domain of the interferon induced protein kinase

Autor: R C, Patel, G C, Sen

Publikováno v: Cellularmolecular biology research. 40(7-8)

The interferon-inducible protein kinase, PKR, requires double-stranded (ds) RNA for its activation. We have previously mapped its dsRNA-binding domain (DRBD) to the amino terminal 170 residues (Patel and Sen, 1992). In the present study, we have char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7715a6f62593a28357e947b6ece8d99c
https://pubmed.ncbi.nlm.nih.gov/7787885

Zobrazit plný text záznamu

Mutations in two specific residues of testicular angiotensin-converting enzyme change its catalytic properties

Autor: I, Sen, S, Kasturi, M, Abdul Jabbar, G C, Sen

Publikováno v: The Journal of biological chemistry. 268(34)

Chemical modifications of 2 specific residues present in angiotensin-converting enzyme (ACE) result in its inactivation, thereby suggesting that these 2 residues may be important for its enzyme activity. We directly tested this hypothesis by substitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af0a656af3b5b9c0e119c8abbf81bf5f
https://pubmed.ncbi.nlm.nih.gov/7902354

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání