Výsledky vyhledávání - "G. C. Mazzenga"

ChemInform Abstract: Synthesis and Benzodiazepine Binding Activity of a Series of Novel (1, 2,4)Triazolo(1,5-c)quinazolin-5(6H)-ones

Autor: W. D. Cash, Albert Braunwalder, P.S. Bernard, G. C. Mazzenga, R. A. Lovell, B. S. Barbaz, Francis John E, J. L. Hyun, Debra A. Bennett, R. C. Friedmann, P. S. Loo

Publikováno v: ChemInform. 22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5e7514324fefecbf5dee278114703a6
https://doi.org/10.1002/chin.199123167

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Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones

Autor: R. A. Lovell, J. L. Hyun, R. C. Friedmann, Francis John E, P. S. Loo, P.S. Bernard, G. C. Mazzenga, B. S. Barbaz, W. D. Cash, Albert Braunwalder

Publikováno v: Journal of medicinal chemistry. 34(1)

Investigation of tricyclic heterocycles related to the 2-arylpyrazolo[4,3-c]quinolin-3(5H)-ones, structures with high affinity for the benzodiazepine (BZ) receptor, led to the synthesis of 2-phenyl-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one, a compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff1e62a2a144f9438eeefcaa2e2a533
https://pubmed.ncbi.nlm.nih.gov/1846920

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A convenient synthesis of 3,5-disubstituted-1,2,4-triazoles

Autor: L. A. Gorczyca, G. C. Mazzenga, H. Meckler, J. E. Francis

Publikováno v: Tetrahedron Letters. 28:5133-5136

The condensation of an acyl hydrazide and an amidine to afford an acylamidrazone, followed by thermal cyclization, provides a convenient method for preparing 3,5-disubstituted-1,2,4-triazoles in high yields.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::416b193e30dcc5d7d328999f645c577d
https://doi.org/10.1016/s0040-4039(00)95610-7

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The relationship of pKa and acute skin irritation in man

Autor: B, Berner, D R, Wilson, R H, Guy, G C, Mazzenga, F H, Clarke, H I, Maibach

Publikováno v: Pharmaceutical research. 5(10)

The relationship between pKa and skin irritation in man is studied for a homologous series of benzoic acid derivatives, which permeate through human skin at comparable rates (15-88 micrograms/cm2/hr). Skin irritation and pKa are correlated for pKa le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5271c02648be72fa86f926f1d84bc525
https://pubmed.ncbi.nlm.nih.gov/3244620

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