Zobrazeno 1 - 10
of 56
pro vyhledávání: '"G. C. Kirby"'
Autor:
G. C. Kirby
Publikováno v:
Animal Blood Groups and Biochemical Genetics. 5:153-157
Summary An electrophoretic mobility variant of a protein band anodal to haemoglobin in alkaline starch gels was found in wild house mouse populations in South Australia. Most wild mice and all inbred lines examined are homozygous for the Erp-1a allel
Publikováno v:
Austral Ecology. 27:343-349
The role of the homokaryotic life stage in the dynamics of fungal communities is relatively unknown. However, homokaryons are thought to be only a temporary stage and are therefore not generally used in ecological experiments with fungi. In this stud
Autor:
M. del Rayo Camacho, D. C. Warhurst, Rachel Mata, J. D. Phillipson, G. C. Kirby, Perla Castañeda, Simon L. Croft
Publikováno v:
Planta Medica. 66:463-468
Bioactivity-directed fractionation of the CHCl3-MeOH extract of the leaves of Celaenodendron mexicanum by means of the brine shrimp lethality test and chromatographic techniques led to the isolation of three carboxylic acid triterpenes, the new tiruc
Publikováno v:
Phytotherapy Research. 13:115-119
The lupane-type triterpene betulinic acid was isolated from an ethanol extract of the root bark of the Tanzanian tree Uapaca nitida Mull-Arg. (Euphorbiaceae). The in vitro antiplasmodial IC50 values of betulinic acid against chloroquine resistant (K1
Autor:
G. C. Kirby
Publikováno v:
Transactions of the Royal Society of Tropical Medicine and Hygiene. 90:605-609
Malaria and other protozoal diseases continue to pose serious health problems world-wide. Resistance of the malaria parasites, Plasmodium spp., to drugs such as chloroquine (and, more lately, quinine) occurs with increasing frequency and underlies th
Publikováno v:
Phytotherapy Research. 9:359-363
Cryptolepine is an indoloquinoline, high yields of which may be extracted from the roots of the West African shrub Cryptolepis sanguinolenta. The use of this plant as a traditional treatment for malaria is widespread in Ghana and is reported to be cl
Autor:
J. D. Phillipson, Colin W. Wright, Zhenping Chen, David J. Allen, G. C. Kirby, David C. Warhurst, Ya Cai, Luc Angenot, Monique Tits
Publikováno v:
Phytotherapy Research. 8:149-152
The in vitro activities of 20 Strychnos alkaloids have been determined against three species of protozoa and the active compounds were then assessed for in vitro cytotoxic activity using KB cells. 3',4'-dihydrousambarensine was the most active agains
Autor:
Koichi Koshimizu, G. C. Kirby, David C. Warhurst, David J. Allen, Hajime Ohigashi, Daisuke Izutsu, P. Timon-David, Balansard Guy, F. Delmas, Colin W. Wright, J. David Phillipson, Michael A. Huffman, Riad Elias, Hiromu Sugiyama, Masanori Kawanaka
Publikováno v:
Journal of Chemical Ecology. 20:541-553
The bitter and related constituents have been isolated fromVernonia amygdalina (Compositae), a plant ingested by wild chimpanzees possibly suffering from parasite-related diseases in the Mahale Mountains National Park, Tanzania. Isolated from the pla
Autor:
J. David Phillipson, G. C. Kirby, Louisette Le Men-Olivier, David C. Warhurst, Georges Massiot, David J. Allen, Colin W. Wright
Publikováno v:
Journal of Ethnopharmacology. 40:41-45
A review of the literature on Alstonia species indicates that evidence in support of their effectiveness in the treatment of malaria is controversial. The antiprotozoal activity of the major alkaloid present in Alstonia species, echitamine, was asses
Publikováno v:
European Journal of Medicinal Chemistry. 28:265-269
Brusatol 2a was converted to the amide 2d, then the hydroxyl function on ring A of both compounds was acylated by a lipidic α-amino acid to give compounds 2b and 2e. To assess the effect of the size of the alkyl side chain on the biological activity