Výsledky vyhledávání - "G. C. Butterfield"

A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate

Autor: L. C. Marinovic, R. T. Ronau, Christopher A. Lipinski, Martin J. Pagnozzi, E. Edward Mena, G. C. Butterfield, Beryl W. Dominy, Bertrand L. Chenard, T. Tsang, Butler Todd W

Publikováno v: Journal of Medicinal Chemistry. 33:1077-1083

A systematic approach to the replacement of acidic groups with potential bioisosteres is described. The strategy involves simple nucleophilic displacement of a common alkyl halide precursor with a variety of mercaptoazoles and related molecules. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d71d71256e38828558dd436f990e8c8
https://doi.org/10.1021/jm00165a030

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