Výsledky vyhledávání - "G. C., Kedar"

Regulation of mprF by Antisense RNA Restores Daptomycin Susceptibility to Daptomycin-Resistant Isolates of Staphylococcus aureus

Autor: Vickie Brown-Driver, Aileen Rubio, Jared Silverman, Robert Haselbeck, G C Kedar, John T. Finn, Mary Conrad

Publikováno v: Antimicrobial Agents and Chemotherapy. 55:364-367

Mutations in mprF have been shown to result in reduced susceptibility to daptomycin and other cationic antibacterials. An mprF antisense-inducible plasmid was constructed and used to demonstrate that depletion of mprF can reestablish susceptibility t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d35ab815f092197ed3c8236f1e3c7f
https://doi.org/10.1128/aac.00429-10

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Elevated Linezolid Resistance in Clinical cfr -Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3

Autor: Shahad Rahawi, Mark Hilgers, Juan J. Picazo, Jeffrey L. Stein, Jeffrey B. Locke, G C Kedar, Karen Joy Shaw, Gracia Morales

Publikováno v: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)

Resistance to linezolid (LZD) occurs through mutations in 23S rRNA and ribosomal proteins L3 and L4 or through methylation of 23S rRNA by Cfr. Here we report novel L3 mutations, ΔSer145/His146Tyr and ΔMet169-Gly174, co-occurring with cfr in LZD-res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4812ae11cea60f8da64f1db67eebebc5
https://doi.org/10.1128/aac.00714-10

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Structure-Activity Relationships of Diverse Oxazolidinones for Linezolid-Resistant Staphylococcus aureus Strains Possessing the cfr Methyltransferase Gene or Ribosomal Mutations

Autor: Shahad Rahawi, John Finn, Mark Hilgers, Juan J. Picazo, Weonbin Im, G C Kedar, Jeffrey L. Stein, Karen Joy Shaw, Jeffrey B. Locke, Gracia Morales

Publikováno v: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)

Staphylococcal resistance to linezolid (LZD) is mediated through ribosomal mutations (23S rRNA or ribosomal proteins L3 and L4) or through methylation of 23S rRNA by the horizontally transferred Cfr methyltransferase. To investigate the structural ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ce51ba992888de7ca742ba26f2d924
https://doi.org/10.1128/aac.00663-10

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Staphylococcus aureus TargetArray: Comprehensive Differential Essential Gene Expression as a Mechanistic Tool To Profile Antibacterials

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:3659-3670

The widespread emergence of antibiotic-resistant bacteria and a lack of new pharmaceutical development have catalyzed a need for new and innovative approaches for antibiotic drug discovery. One bottleneck in antibiotic discovery is the lack of a rapi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef24b11300e85697e329f0d477979d7
https://doi.org/10.1128/aac.00308-10

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Comparison of the Essential Cellular Functions of the Two murA Genes of Bacillus anthracis

Autor: Mark Stidham, Daniel R. Reyes, Vickie Brown-Driver, G C Kedar, Robert Haselbeck, John T. Finn, Karen Joy Shaw, Mark Hilgers

Publikováno v: Antimicrobial Agents and Chemotherapy. 52:2009-2013

Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis . Antisense-based modulation of murA1 gene expression hyperse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792cab45815141765055fcc25d63c63c
https://doi.org/10.1128/aac.01594-07

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Evaluation of the metS and murB Loci for Antibiotic Discovery Using Targeted Antisense RNA Expression Analysis in Bacillus anthracis

Autor: G C Kedar, Daniel R. Reyes, Mark Stidham, Vickie Brown-Driver, Mark Hilgers, Karen Joy Shaw, Robert Haselbeck, John T. Finn

Publikováno v: Antimicrobial Agents and Chemotherapy. 51:1708-1718

The biowarfare-relevant bacterial pathogen Bacillus anthracis contains two paralogs each of the metS and murB genes, which encode the important antibiotic target functions methionyl-tRNA synthetase and UDP- N -acetylenolpyruvoylglucosamine reductase,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76959466862ccd46e9963ab481552e80
https://doi.org/10.1128/aac.01180-06

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The Synchrony Phenotype Persists after Elimination of Multiple GATC Sites from the dnaA Promoter of Escherichia coli

Autor: Douglas W. Smith, Terry G. Wilkinson, Elena C. Guzmán, Judith W. Zyskind, Chi Lee, G C Kedar

Publikováno v: Journal of Bacteriology. 188:4573-4576

To examine whether methylation of the GATC sites present in the dnaA promoter region is responsible for the strict temporal coordination of initiation events at oriC as measured by the synchrony of initiation, we introduced point mutations eliminatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537800dd9ace61ea1478b6a40c6dd0f8
https://doi.org/10.1128/jb.00089-06

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A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

Publikováno v: Molecular Microbiology. 43:1387-1400

Summary To address the need for new approaches to antibiotic drug development, we have identified a large number of essential genes for the bacterial pathogen, Staphylococcus aureus, using a rapid shotgun antisense RNA method. Staphylococcus aureus c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7246a51da87159b16267f8e63469ae1f
https://doi.org/10.1046/j.1365-2958.2002.02832.x

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Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening

Autor: Mark Stidham, Mark Hilgers, G C Kedar, John T. Finn

Publikováno v: Bioorganicmedicinal chemistry letters. 18(14)

Multiple inhibitors of the antibacterial target, Staphylococcus aureus MetRS, were identified by virtual screening. The process consisted of building a Catalyst® pharmacophore from a ligand-S. aureus MetRS structure and using this pharmacophore to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38bcf8a90003a6fff6d87e31e2c9a56
https://pubmed.ncbi.nlm.nih.gov/18590962

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Role of DNA methylation at GATC sites in the dnaA promoter, dnaAp2

Autor: G C, Kedar, F, Ozcan, E C, Guzmán, D W, Smith, V G, Newman, J W, Zyskind

Publikováno v: Journal of molecular microbiology and biotechnology. 2(3)

DnaA protein is required for the initiation of DNA replication at the bacterial chromosomal origin, oriC, and at the origins of many plasmids. The concentration of DnaA protein is an important factor in determining when initiation occurs during the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb3fcf7420241bf42b0529f0ffa93a67
https://pubmed.ncbi.nlm.nih.gov/10937439

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