Zobrazeno 1 - 10
of 60
pro vyhledávání: '"G. Brent Irvine"'
Autor:
Rivka Ravid, Simon Brockbank, David T.R. Coulson, Joseph F. Quinn, Jan Hellemans, Janet A. Johnston, Nancy Beyer, G. Brent Irvine
Publikováno v:
Brain Research, 1459, 71-80. Elsevier B.V.
α-Synuclein is a neuronal protein implicated in the etiology of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Whilst increased α-synuclein expression due to gene duplication or triplication can cause familial PD, previous studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13561297a3a8d7dab1337b966befcf3
https://doi.org/10.1016/j.brainres.2012.04.018
https://doi.org/10.1016/j.brainres.2012.04.018
Autor:
David T.R. Coulson, Nancy Beyer, Simon Brockbank, Jan Hellemans, Joseph F. Quinn, Janet A. Johnston, G. Brent Irvine, Rivka Ravid
Publikováno v:
Journal of Alzheimer's Disease, 22, 1111-1122. IOS Press
β-site AβPP cleaving enzyme 1 (BACE1) catalyses the rate-limiting step for production of amyloid-β (Aβ) peptides, involved in the pathological cascade underlying Alzheimer's disease (AD). Elevated BACE1 protein levels and activity have been repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188572f42cc9166049726f99c0f43b6a
https://doi.org/10.3233/jad-2010-101254
https://doi.org/10.3233/jad-2010-101254
Autor:
A. Peter Passmore, M. McConville, G. Brent Irvine, Stephen Todd, W.W. Liu, David T.R. Coulson, Bernadette McGuinness, Janet A. Johnston, David Craig
Publikováno v:
Journal of Neurochemistry. 108:341-349
Research into the cause of Alzheimer's disease (AD) has identified strong connections to cholesterol. Cholesterol and cholesterol esters can modulate amyloid precursor protein (APP) processing, thus altering production of the Abeta peptides that depo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee48d996d400decafdccd9c779bfeacb
https://doi.org/10.1111/j.1471-4159.2008.05753.x
https://doi.org/10.1111/j.1471-4159.2008.05753.x
Autor:
Jeremy T. Stone, David Gosal, Sarah Lincoln, J. Mark Gibson, Timothy Lynch, Matthew J. Farrer, Janet A. Johnston, Owen A. Ross, G. Brent Irvine, Michael G. Heckman
Publikováno v:
Mechanisms of Ageing and Development. 128:378-382
Genetic variation of the α- synuclein gene ( SNCA ) is known to cause familial parkinsonism, however the role of SNCA variants in sporadic Parkinson's disease (PD) remains elusive. The present study identifies an association of common SNCA polymorph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406f3f577dbeabbe3ba118d58454b5bb
https://doi.org/10.1016/j.mad.2007.04.002
https://doi.org/10.1016/j.mad.2007.04.002
Autor:
G. Brent Irvine, Angela M. Bodles
Publikováno v:
Protein & Peptide Letters. 11:271-279
Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dcbc592651caf1390eeec7af6812434
https://doi.org/10.2174/0929866043407084
https://doi.org/10.2174/0929866043407084
Publikováno v:
Neuroscience Letters. 359:89-93
Alpha-synuclein has been linked to amyloidogenesis in Parkinson's disease and other neurodegenerative disorders. We have previously shown that a peptide comprising residues 68-78 of alpha-synuclein is the minimum fragment that, like alpha-synuclein i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1941beec5903fc404ad7af0e0b93c2a0
https://doi.org/10.1016/j.neulet.2003.12.077
https://doi.org/10.1016/j.neulet.2003.12.077
Autor:
G. Brent Irvine
Publikováno v:
Journal of Biochemical and Biophysical Methods. 56:233-242
Gel filtration on soft gels has been employed for over 40 years for the separation, desalting and molecular weight estimation of peptides and proteins. Technical improvements have given rise to high-performance size-exclusion chromatography (HPSEC) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5222eb53350359ac466b4640bda590b3
https://doi.org/10.1016/s0165-022x(03)00061-7
https://doi.org/10.1016/s0165-022x(03)00061-7
Publikováno v:
Journal of Neurochemistry. 78:384-395
The non-beta-amyloid (Abeta) component of Alzheimer's disease amyloid (NAC) and its precursor alpha-synuclein have been linked to amyloidogenesis in several neurodegenerative diseases. NAC and alpha-synuclein both form beta-sheet structures upon agei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dbd6488e31b7eabab11af7bc6c35ce3
https://doi.org/10.1046/j.1471-4159.2001.00408.x
https://doi.org/10.1046/j.1471-4159.2001.00408.x
Autor:
Omar M. A. El-Agnaf, G. Brent Irvine
Publikováno v:
Journal of Structural Biology. 130:300-309
Synucleinsare small proteins that are highly expressed in brain tissue and are localised at presynaptic terminals in neurons. alpha-Synuclein has been identified as a component of intracellular fibrillar protein deposits in several neurodegenerative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e5ee8e0d175cf1d97a6823fc8e52d8
https://doi.org/10.1006/jsbi.2000.4262
https://doi.org/10.1006/jsbi.2000.4262
Publikováno v:
European Journal of Biochemistry. 267:2186-2194
The non-Abeta component of Alzheimer's disease amyloid (NAC) and its precursor alpha-synuclein have been linked to amyloidogenesis in Alzheimer's disease (AD), Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Previously we have shown tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a412f23dcba2fac30dcaed648a24b16e
https://doi.org/10.1046/j.1432-1327.2000.01219.x
https://doi.org/10.1046/j.1432-1327.2000.01219.x