Zobrazeno 1 - 10
of 12
pro vyhledávání: '"G. Brent Dawe"'
Autor:
G. Brent Dawe, Hong Yu, Shenyan Gu, Alissa N. Blackler, Jose A. Matta, Edward R. Siuda, Elizabeth B. Rex, David S. Bredt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The α7 nicotinic acetylcholine receptor (nAChR) plays a major role in shaping the activity of neuronal circuits and contributes to the pathophysiology of several neurological disorders. Following cDNA library screening, the authors identify anti-apo
Externí odkaz:
https://doaj.org/article/94a386d702d14777ad23a1ac9956e5a0
Publikováno v:
The Oxford Handbook of Neuronal Ion Channels ISBN: 9780190669164
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate-type glutamate receptors (AMPARs and KARs) are dynamic ion channel proteins that govern neuronal excitation and signal transduction in the mammalian brain. The four AMPAR and fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc713b851f637419794f59f0ac50faa2
https://doi.org/10.1093/oxfordhb/9780190669164.013.8
https://doi.org/10.1093/oxfordhb/9780190669164.013.8
Autor:
James Limberis, Daniel Knowland, Anindya Bhattacharya, William A. Eckert, Alan D. Wickenden, Shenyan Gu, David S. Bredt, Jose A. Matta, G. Brent Dawe
Publikováno v:
J Clin Invest
The α6β4 nicotinic acetylcholine receptor (nAChR) is enriched in dorsal root ganglia neurons and is an attractive non-opioid therapeutic target for pain. However, difficulty expressing human α6β4 receptors in recombinant systems has precluded dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f464fbb456e637e38b2ed016a2e6e25d
https://pubmed.ncbi.nlm.nih.gov/33074245
https://pubmed.ncbi.nlm.nih.gov/33074245
Publikováno v:
Physiology of Neurons ISBN: 9780429292972
Physiology of Neurons
Physiology of Neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f41af8e26eea3e778700462afcc01ab
https://doi.org/10.1201/9780429292972-9
https://doi.org/10.1201/9780429292972-9
Autor:
Elizabeth B. Rex, Shenyan Gu, Edward R. Siuda, Alissa N. Blackler, G. Brent Dawe, Jose A. Matta, Hong Yu, David S. Bredt
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nicotinic acetylcholine receptors (nAChRs) mediate and modulate synaptic transmission throughout the brain, and contribute to learning, memory, and behavior. Dysregulation of α7-type nAChRs in neuropsychiatric as well as immunological and oncologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54da56d29f61a21edce7e77922b573e4
https://doi.org/10.1038/s41467-019-10723-x
https://doi.org/10.1038/s41467-019-10723-x
Publikováno v:
The Journal of Physiology. 593:97-110
Ionotropic glutamate receptors (iGluRs) are the major excitatory neurotransmitter receptor in the vertebrate CNS and, as a result, their activation properties lie at the heart of much of the neuronal network activity observed in the developing and ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e4a8ce398a5ecb76e11f5eec170237f
https://doi.org/10.1113/jphysiol.2014.277921
https://doi.org/10.1113/jphysiol.2014.277921
Publikováno v:
Cell Reports. 26:866-874.e3
Acetylcholine gates a large family of nicotinic receptor cation channels that control neuronal excitation and neurotransmitter release. These receptors are key targets for neuropsychiatric disorders; however, difficulties in expressing nicotinic acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f41180f993dc199dbd53572a20b02e1
https://doi.org/10.1016/j.celrep.2018.12.103
https://doi.org/10.1016/j.celrep.2018.12.103
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(11)
KA receptors have shown to be potential therapeutic targets in CNS diseases such as schizophrenia, depression, neuropathic pain and epilepsy. Through the use of our docking tool Fitted, we investigated the relationship between ligand activity towards
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0156135f35a9eca6e7f22b47846342ad
https://pubmed.ncbi.nlm.nih.gov/25913117
https://pubmed.ncbi.nlm.nih.gov/25913117
Publikováno v:
The Journal of physiology. 593(1)
Ionotropic glutamate receptors (iGluRs) are the major excitatory neurotransmitter receptor in the vertebrate CNS and, as a result, their activation properties lie at the heart of much of the neuronal network activity observed in the developing and ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a8290b64f05e091f9c16cf4972ca541
https://pubmed.ncbi.nlm.nih.gov/25556791
https://pubmed.ncbi.nlm.nih.gov/25556791
Autor:
G. Brent Dawe, Bryan A. Daniels, Elizabeth D. Andrews, Derek Bowie, Maria Musgaard, Mark R. P. Aurousseau, Philip C. Biggin
Publikováno v:
Nature structural & molecular biology
Desensitization is an important mechanism that curtails the activity of ligand-gated ion-channels (LGICs). Although the structural basis of desensitization is not fully resolved, it is thought to be governed by the physicochemical properties of the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4095fe601a32467ac2f7654235e2c1bd
http://ora.ox.ac.uk/objects/uuid:798949c7-8690-4957-8ca6-617e209c65f4
http://ora.ox.ac.uk/objects/uuid:798949c7-8690-4957-8ca6-617e209c65f4