Zobrazeno 1 - 10
of 86
pro vyhledávání: '"G. Breipohl"'
Publikováno v:
Nucleosides and Nucleotides. 18:393-401
The preparation of a novel phosphoramidite monomer based on thyminyl acetic acid coupled to the secondary nitrogen of 2-(2-amino-ethylamino)ethanol is described. This monomer can be used to attach a deoxynucleotide to the carboxy terminus of a PNA ol
Publikováno v:
Nucleosides and Nucleotides. 16:603-608
The synthesis of polyamide nucleic acids (PNAs) and derivatives thereof by different synthetic routes is described. The first strategy makes use of 9-Fluorenylmethoxycarbonyl (Fmoc)/monomethoxytrityl (Mmt) protected building blocks, whereas the secon
Publikováno v:
Analytical Biochemistry. 228:35-41
Bradykinin (BK) and kallidin (KAL) derivatives containing a Cys residue instead of a Ser residue at positions 6 and 7, respectively [BK(Cys6), KAL(Cys7)], were synthesized. These derivatives were linked to BSA via the Cys residue by a heterobifunctio
Autor:
Ursula Quitterer, Werner Müller-Esterl, M Haasemann, A. Maidhof, Said Abd Alla, G. Breipohl, J. Knolle, J Buschko
Publikováno v:
Journal of Biological Chemistry. 268:17277-17285
The human bradykinin B2 receptor belongs to the family of G-protein-coupled receptors. To characterize the receptor protein, we have solubilized the membranes of cultured human foreskin fibroblasts bearing the B2 receptor. Affinity cross-linking of t
Publikováno v:
ChemInform. 30
Autor:
A, Peyman, K, Scheunemann, D W, Will, J, Knolle, V, Wehner, G, Breipohl, H U, Stilz, D, Carniato, J, Ruxer, J, Gourvest, M, Auberval, B, Doucet, R, Baron, M, Gaillard, T R, Gadek, S, Bodary
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(15)
A series of novel, highly potent alpha(v)beta(3) antagonists based on a thiophene scaffold and containing an acylguanidine as an Arg-mimetic is described. A number of structural features, such as cyclic versus open guanidine and a variety of lipophil
Autor:
A, Peyman, V, Wehner, J, Knolle, H U, Stilz, G, Breipohl, K H, Scheunemann, D, Carniato, J M, Ruxer, J F, Gourvest, T R, Gadek, S, Bodary
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(2)
The synthesis of a series of RGD mimetic alpha(v)beta3 antagonists containing a hydantoin scaffold is shown. The results demonstrate some of the structural requirements for the design of selective alpha(v)beta3 antagonists (vs alpha(IIb)beta3) in ter
Autor:
S A, Alla, J, Buschko, U, Quitterer, A, Maidhof, M, Haasemann, G, Breipohl, J, Knolle, W, Müller-Esterl
Publikováno v:
The Journal of biological chemistry. 268(23)
The human bradykinin B2 receptor belongs to the family of G-protein-coupled receptors. To characterize the receptor protein, we have solubilized the membranes of cultured human foreskin fibroblasts bearing the B2 receptor. Affinity cross-linking of t
Publikováno v:
Agents and actions. Supplements. 38
Publikováno v:
Agents and actions. Supplements. 38
Methods have been optimised for the collection of synovial fluid and the chromatographic separation of individual kinins (bradykinin and kallidin) in the fluid by HPLC. In addition, the stability of the kinin antagonist, Hoe 140, in synovial fluid wa