Zobrazeno 1 - 10
of 875
pro vyhledávání: '"G. Boyer"'
Publikováno v:
Cells, Vol 13, Iss 17, p 1443 (2024)
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular mechanism of the origin and development of uLMS is limited. Bromodomain and e
Externí odkaz:
https://doaj.org/article/5645efaaa8624612a6e767075703824a
Autor:
Azna Zuberi, Yongchao Huang, Ariel J. Dotts, Helen Wei, John S. Coon V, Shimeng Liu, Takashi Iizuka, Olivia Wu, Olivia Sotos, Priyanka Saini, Debabrata Chakravarti, Thomas G. Boyer, Yang Dai, Serdar E. Bulun, Ping Yin
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiomyomas that
Externí odkaz:
https://doaj.org/article/d0e7da5cad5e4be6b2a1e703a85ac26f
Autor:
Justin G. Boyer, Jiuzhou Huo, Sarah Han, Julian R. Havens, Vikram Prasad, Brian L. Lin, David A. Kass, Taejeong Song, Sakthivel Sadayappan, Ramzi J. Khairallah, Christopher W. Ward, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Boyer et al. created genetic mouse models of muscular dystrophy in which satellite cells were selectively depleted. The depletion of satellite cells at select times was protective. Myofibers no longer had plasma membrane instability leading to tissue
Externí odkaz:
https://doaj.org/article/05d4e5eb19ab42dd9227ed224828f09d
Autor:
Sribalasubashini Muralimanoharan, Ross Shamby, Nicholas Stansbury, Robert Schenken, Barbara de la Pena Avalos, Samin Javanmardi, Eloise Dray, Patrick Sung, Thomas G. Boyer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Uterine fibroid (UF) driver mutations in Mediator complex subunit 12 (MED12) trigger genomic instability and tumor development through unknown mechanisms. Herein, we show that MED12 mutations trigger aberrant R-loop-induced replication stres
Externí odkaz:
https://doaj.org/article/c0125838d6f34460b746424e73028e09
Autor:
Marius V. Dannappel, Danxi Zhu, Xin Sun, Hui Kheng Chua, Marle Poppelaars, Monica Suehiro, Subash Khadka, Terry C.C. Lim Kam Sian, Dhanya Sooraj, Melissa Loi, Hugh Gao, Daniel Croagh, Roger J. Daly, Pouya Faridi, Thomas G. Boyer, Ron Firestein
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
Initiation and maintenance of transcriptional states are critical for controlling normal tissue homeostasis and differentiation. The cyclin dependent kinases CDK8 and CDK19 (Mediator kinases) are regulatory components of Mediator, a highly conserved
Externí odkaz:
https://doaj.org/article/3d46bbee8ab546fa96a8734f41d7728e
Autor:
Dannielle Joy Davis, Patricia G. Boyer
The focus of Social Justice Issues and Racism in the College Classroom is faculty and students of color at postsecondary institutions and the racial challenges they encounter in college classrooms. To achieve this aim, the book highlights the voices
Autor:
Amber N. Edinoff, Haseeb A. Akuly, Tony A. Hanna, Carolina O. Ochoa, Shelby J. Patti, Yahya A. Ghaffar, Alan D. Kaye, Omar Viswanath, Ivan Urits, Andrea G. Boyer, Elyse M. Cornett, Adam M. Kaye
Publikováno v:
Neurology International, Vol 13, Iss 3, Pp 387-401 (2021)
Depression is the most prevalent psychiatric disorder in the world, affecting 4.4% of the global population. Despite an array of treatment modalities, depressive disorders remain difficult to manage due to many factors. Beginning with the introductio
Externí odkaz:
https://doaj.org/article/b59af2b8ce67428582df8f8eede83c5c
Autor:
Amber N. Edinoff, Haseeb A. Akuly, John H. Wagner, Megan A. Boudreaux, Leah A. Kaplan, Shadman Yusuf, Elisa E. Neuchat, Elyse M. Cornett, Andrea G. Boyer, Adam M. Kaye, Alan D. Kaye
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in children. Over the past twenty years, research on the disease and its characteristics and treatment options has grown exponentially. The first-line phar
Externí odkaz:
https://doaj.org/article/07be901847a44d4299d98a4ce9339f61
Autor:
Qiwei Yang, Ali Falahati, Azad Khosh, Hanaa Mohammed, Wenjun Kang, Ana Corachán, Maria Victoria Bariani, Thomas G. Boyer, Ayman Al-Hendy
Publikováno v:
Cells, Vol 11, Iss 23, p 3801 (2022)
Uterine leiomyosarcoma (uLMS) is the most frequent subtype of uterine sarcoma that presents a poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular mechanism of the origin and development of uLMS is unknown. Class I histo
Externí odkaz:
https://doaj.org/article/01e8f95f36364dc58c43db4885f06593
Autor:
Changming Tan, Siting Zhu, Zee Chen, Canzhao Liu, Yang E Li, Mason Zhu, Zhiyuan Zhang, Zhiwei Zhang, Lunfeng Zhang, Yusu Gu, Zhengyu Liang, Thomas G Boyer, Kunfu Ouyang, Sylvia M Evans, Xi Fang
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009785 (2021)
Dysregulation of cardiac transcription programs has been identified in patients and families with heart failure, as well as those with morphological and functional forms of congenital heart defects. Mediator is a multi-subunit complex that plays a ce
Externí odkaz:
https://doaj.org/article/18fca6d6e79348038660f42598de6a01