Výsledky vyhledávání

Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4/ROS/NF-κB/MMP-9 signaling pathway

Autor: Herbert Y. Gaisano, Daniel Richards, Brenda Oliver, Marcelo G. Binker, Laura I. Cosen-Binker, Makena J. Binker-Cosen

Publikováno v: Biochemical and Biophysical Research Communications. 484:152-158

Pancreatic cancer (PC) is an aggressive malady with proclivity for early metastasis. Overexpression of toll-like receptor 4 (TLR4) in pancreatic ductal adenocarcinoma, the most common type of pancreatic malignancy, correlates to tumor size, lymph nod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca83e45755ff4051e02dbffb5f09026
https://doi.org/10.1016/j.bbrc.2017.01.051

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TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2

Autor: Herbert Y. Gaisano, Andres A. Binker-Cosen, Marcelo G. Binker, Rodica H. de Cosen, Laura I. Cosen-Binker

Publikováno v: Biochemical and Biophysical Research Communications. 405:140-145

Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-β1) has been shown to increase both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a43e3b89c8d4531930464eb1bd8bcd3
https://doi.org/10.1016/j.bbrc.2011.01.023

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Hypoxia–reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2

Autor: Rodica H. de Cosen, Herbert Y. Gaisano, Andres A. Binker-Cosen, Daniel Richards, Marcelo G. Binker, Laura I. Cosen-Binker

Publikováno v: Biochemical and Biophysical Research Communications. 393:371-376

Pancreatic cancer is an aggressive malignancy with proclivity to early metastasis. High expression and activation of the collagenase matrix metalloproteinase-2 (MMP-2) have been found in human pancreatic cancer tissues, being these increased levels o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6005340a5691e97ef62e1d69b42eda2
https://doi.org/10.1016/j.bbrc.2010.01.125

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Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice

Autor: Andres A. Binker-Cosen, Herbert Y. Gaisano, Laura I. Cosen-Binker, Marcelo G. Binker

Publikováno v: Experimental Physiology. 93:1091-1103

Pancreatitis is a disease with high morbidity and mortality. In vitro experiments on pancreatic acini showed that supramaximal but not submaximal cholecystokinin (CCK) stimulation induces effects in the acinar cell that can be correlated with acinar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc7b59a236078219adbe8c3db1b7e3c1
https://doi.org/10.1113/expphysiol.2008.043141

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Cytoplasmic Linker Protein-170 Enhances Spreading and Phagocytosis in Activated Macrophages by Stabilizing Microtubules

Autor: Dorothy Yanling Zhao, Rene E. Harrison, Sophie J. Y. Pang, Marcelo G. Binker

Publikováno v: The Journal of Immunology. 179:3780-3791

Activation of macrophages causes increased cell spreading, increased secretion of cytokines and matrix metalloproteinases, and enhanced phagocytosis. The intracellular mechanisms driving the up-regulation of these activities have not been completely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210627c599c0081ef4a980b8e03dffd7
https://doi.org/10.4049/jimmunol.179.6.3780

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Omega-3 PUFA docosahexaenoic acid decreases LPS-stimulated MUC5AC production by altering EGFR-related signaling in NCI-H292 cells

Autor: Daniel Richards, Marcelo G. Binker, Makena J. Binker-Cosen, Laura I. Cosen-Binker, Andres A. Binker-Cosen, Steven D. Freedman

Publikováno v: Biochemical and biophysical research communications. 463(4)

Chronic obstructive pulmonary disease (COPD) is an inflammatory process characterized by airway mucus hypersecretion. Lipopolysaccharides (LPS) are known to stimulate the production of mucin 5AC (MUC5AC) via epidermal growth factor receptor (EGFR) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871517195798b8ea4fbedb0283b2705b
https://pubmed.ncbi.nlm.nih.gov/26079889

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ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation

Autor: Marcelo G. Binker, Daniel Richards, Herbert Y. Gaisano, Laura I. Cosen-Binker

Publikováno v: Biochemical and biophysical research communications. 463(3)

Pancreatitis has been suspected for a long time to have an autodigestive genesis. The main events occurring in the pancreatic acinar cell that initiate acute pancreatitis include inhibition of zymogen secretion and intracellular activation of proteas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f989aaf2b8f9e43272b37a289714c1bc
https://pubmed.ncbi.nlm.nih.gov/26022124

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