Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis

Autor: F. A. Tucci, R. Pennisi, D. C. Rigiracciolo, M. G. Filippone, R. Bonfanti, F. Romeo, S. Freddi, E. Guerrera, C. Soriani, S. Rodighiero, R. H. Gunby, G. Jodice, F. Sanguedolce, G. Renne, N. Fusco, P. P. Di Fiore, G. Pruneri, G. Bertalot, G. Musi, G. Vago, D. Tosoni, S. Pece

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)

Abstract Advances in bladder cancer (BCa) treatment have been hampered by the lack of predictive biomarkers and targeted therapies. Here, we demonstrate that loss of the tumor suppressor NUMB promotes aggressive bladder tumorigenesis and worsens dise

Externí odkaz: https://doaj.org/article/e633256b3da04f098ba66dc7a3cd81cb

Clinical Presentation and Long‐Term Survival Outcomes of Patients With Monoclonal Gammopathy of Renal Significance (MGRS): A Multicenter Retrospective Study

Autor: K. Mancuso, R. Mina, S. Rocchi, E. Antonioli, M. T. Petrucci, F. Fazio, A. Gozzetti, M. Salvini, C. S. Cartia, G. Bertuglia, F. Patriarca, A. B. Dalla Palma, S. Barbato, G. De Cicco, F. Bigi, E. Favero, P. Tacchetti, L. Pantani, I. Rizzello, M. Puppi, M. Talarico, V. Solli, A. Kanapari, M. Cavo, E. Zamagni

Publikováno v: Cancer Medicine, Vol 13, Iss 22, Pp n/a-n/a (2024)

ABSTRACT Introduction MGRS are new rare clinical entities, whose recognition and optimal management is evolving. Methods To implement real‐life data, we retrospectively analysed a multicentre cohort of 60 patients with renal biopsy‐proven MGRS re

Externí odkaz: https://doaj.org/article/0ce5afe23e09445b8e48ac9c3fd5af9d

Evaluation of quality of life after nonoperative or operative management of proximal femoral fractures in frail institutionalized patients

Autor: Sverre A I, Loggers, Hanna C, Willems, Romke, Van Balen, Taco, Gosens, Suzanne, Polinder, Kornelis J, Ponsen, Cornelis L P, Van de Ree, Jeroen, Steens, Michael H J, Verhofstad, Rutger G, Zuurmond, Esther M M, Van Lieshout, Pieter, Joosse, G Bert, Ziere

Publikováno v: JAMA Surgery, 157(5), 424-434. American Medical Association
JAMA surgery, 157(5), 424-434. American Medical Association
JAMA Surgery, 157(5), 424-434. AMER MEDICAL ASSOC
JAMA Surg

Importance Decision-making on management of proximal femoral fractures in frail patients with limited life expectancy is challenging, but surgical overtreatment needs to be prevented. Current literature provides limited insight into the true outcomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0df2dddd00b10f84a819f166e9cb066
https://hdl.handle.net/1887/3514693

The microRNA miR-132 is a key regulator of lymphatic vascular remodelling

Autor: Valeria Arcucci, Musarat Ishaq, Sally Roufail, B. Kate Dredge, Andrew G. Bert, Emily Hackett-Jones, Ruofei Liu, Katherine A. Pillman, Stephen B. Fox, Steven A. Stacker, Gregory J. Goodall, Marc G. Achen

Lymphangiogenesis (growth of new lymphatic vessels), and lymphatic remodelling more broadly, are important for disease progression in cancer, lymphedema and the pulmonary disease lymphangioleiomyomatosis. Multiple molecular pathways which signal for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39a80d7408173b1bb02ccf424f86025b
https://doi.org/10.1101/2021.12.22.473780

An observational network of ground surface temperature under different land-cover types on the northeastern Qinghai–Tibet Plateau

Autor: R.-D. Şerban, H. Jin, M. Şerban, G. Bertoldi, D. Luo, Q. Wang, Q. Ma, R. He, X. Jin, X. Li, J. Tang, H. Wang

Publikováno v: Earth System Science Data, Vol 16, Pp 1425-1446 (2024)

Ground surface temperature (GST), measured at approximately 5 cm in depth, is a key controlling parameter for subsurface biophysical processes at the land–atmosphere boundary. This work presents a valuable dataset of GST observations at various spa

Externí odkaz: https://doaj.org/article/67b3836841c54494b5808bbca2d91a74