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Akademický článek

Prospects for the use of sulfur-containing pteridines in toxic liver damage

Autor: N. Lohvinenko, V. Shvets, G. Berest, I. Nosulenko, O. Voskoboinik, H. Severina, S. Okovytyy, S. Kovalenko

Publikováno v: Regulatory Mechanisms in Biosystems, Vol 15, Iss 2, Pp 374-381 (2024)

The presented material describes the results of the purposeful search for the novel hepatoprotective agents among synthetic sulfur-containing pteridines. The studied compounds were obtained using previously described synthetic procedures. SwissADME a

Externí odkaz: https://doaj.org/article/de1591966dda49ca8a2a6dcd67c0ec76

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Akademický článek

Complete invagination of the vermiform appendix of the cecum – a rare case in surgical practice

Autor: B. V. Sigua, V. P. Zemlyanoy, A. A. Kurkov, D. G. Berest, S. A. Vinnichuk, N. G. Lyubimov

Publikováno v: Вестник хирургии имени И.И. Грекова, Vol 179, Iss 6, Pp 72-76 (2021)

An extremely rare case of complete invagination of the vermiform appendix in a 45-year-old female patient caused by endometriosis is presented. Difficulties of preoperative diagnostics and determination of treatment tactics in the absence of specific

Externí odkaz: https://doaj.org/article/9b80692e983a4a1ca1c65d85cfd9029d

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Akademický článek

2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl-)alkyl-(alkaryl-,aryl-)-amines and their derivatives. Message 2. The synthesis of (3Н-quinazoline-4-ylidene)hydrazides N-protected aminoacids, using a variety of amine-protecting approaches. Physical-chemical prop

Autor: Yu. V. Martynenko, M. S. Kazunin, I. S. Nosulenko, G. G. Berest, S. І. Kоvalenko, O. M. Kamyshnyi, N. M. Polishchuk

Publikováno v: Zaporožskij Medicinskij Žurnal, Iss 3, Pp 413-420 (2018)

The synthetic potential of (3H-quinazoline-4-ylidene)hydrazides of carboxylic acids is significant in the context of new s-triazoloquinazolines creation and the obtained data of biological activity is a valid reason for the development of new methods

Externí odkaz: https://doaj.org/article/857193776b0b4e5b8b49648137f64ae5

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Akademický článek

3'-R-Spiro[cycloalkyl-1(2), (hetaryl-3(4), 6'-[1,2,4]triazino[2,3-c]quinazoline]-2'(7'H)-2-оnes as a perspective class of compounds with actoprotective activity

Autor: O. S. Kolomoets, О. Yu. Voskoboynik, I. S. Nosulenko, O. V. Krivoshey, A. I. Avramenko, G. G. Berest, S. I. Kovalenko

Publikováno v: Zaporožskij Medicinskij Žurnal, Iss 2, Pp 227-232 (2017)

Quinazolines and their derivatives are a perspective class of compounds with versatile biological activities. Their representatives are used in medical practice as sleeping, diuretic, antimicrobial and antitumor drugs. Continuing our search of perspe

Externí odkaz: https://doaj.org/article/7070b8a7eff44d6297c643bb7a04b9f0

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Akademický článek

Actoprotective activity of 6-monosubstituted 3-R-6,7-dihydro-2H-[1,2,4]triazino-[2,3-c]quinazoline-2-ones

Autor: O. S. Kolomoets, I. S. Nosulenko, О. Yu. Voskoboynik, G. G. Berest, S. I. Kovalenko, S. D. Trzhetsinsky

Publikováno v: Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Iss 3, Pp 59-66 (2016)

Aim. Currently drugs with actoprotective activity are increasingly applied in sport medicine, military medicine, space medicine, emergence medicine, deep-see medicine rehabilitative medicine during high physical stresses. Purposeful search of actopro

Externí odkaz: https://doaj.org/article/7c7c4bcf30fd4a519d27906a1f8a7b85

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Akademický článek

Methodology for prediction of anticancer action of (2-oxo-2H-[1,2,4]¬triazino[2,3-c]-quinazolin-6-yl)thiones via QSAR and docking studies

Autor: I. S. Nosulenko, O. Yu. Voskoboynik, O. M. Antypenko, G. G. Berest, S. I. Kovalenko

Publikováno v: Zaporožskij Medicinskij Žurnal, Iss 1, Pp 99-104 (2015)

Aimed to elaborate new group of protein kinase inhibitors we conducted receptor-based screening (docking, QSAR modeling) and biochemical testing for derivatives of (2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thiones. Methods and results. This

Externí odkaz: https://doaj.org/article/f1825b40355847be9ee7c30c9c75ad3f

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2-[(3-Aminoalkyl-(alkaryl-,aryl-))-1H-1,2,4-triazol-5-yl]anilines: synthesis and anticonvulsant activity

Autor: Sergiy Kovalenko, I. F. Belenichev, Yulya Martynenko, Oleksiy Voskoboinik, Nina Bukhtiayrova, G. G. Berest

Publikováno v: Turkish Journal of Chemistry

The presented work is devoted to the development of synthesis methods for novel 2-[(3-aminoalkyl-(alkaryl-, aryl-))-1H-1,2,4-triazolo]anilines. Abovementioned compounds were obtained via hydrazinolysis (Ing-Manske procedure) and acid hydrolysis of co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0991c38aab4cc32957c447aec3b22306
http://europepmc.org/articles/PMC7671191

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Directed Search of Anti-inflammatory Agents Among (3H-Quinazoline-4-ylidene)hydrazides of N-protected Amino acids and their Heterocyclization Products

Autor: Oleksii M. Antypenko, Sergii Ivanovich Kovalenko, I. S. Nosulenko, G. G. Berest, Yulya Martynenko

Publikováno v: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Background: (Quinazoline-4-ylidene)hydrazides are valued intermediates in modern organic chemistry, as they are commonly used for the synthesis of substituted [1,2,4]triazolo[1,5-c]quinazolines. Objective: Unknown N-acyl-2-([1,2,4]triazolo[1,5-c]quin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e633eaaf9935f83599f85687ff7d7591
http://europepmc.org/articles/PMC7460736

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