Zobrazeno 1 - 10
of 606
pro vyhledávání: '"G. Angus"'
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102745- (2023)
Summary: Mitochondrial morphology is an indicator of cellular health and function; however, its quantification and categorization into different subclasses is a complicated process. Here, we present a protocol for mitochondrial morphology quantificat
Externí odkaz:
https://doaj.org/article/57022801fcad4de5b77664037dfdafc2
Autor:
Sudeshna Nag, Kaitlin Szederkenyi, Olena Gorbenko, Hannah Tyrrell, Christopher M. Yip, G. Angus McQuibban
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112895- (2023)
Summary: Mitochondrial morphology is regulated by the post-translational modifications of the dynamin family GTPase proteins including mitofusin 1 (MFN1), MFN2, and dynamin-related protein 1 (DRP1). Mitochondrial phosphatase phosphoglycerate mutase 5
Externí odkaz:
https://doaj.org/article/0b91a0e048ae469d8f491581d001ba5d
Autor:
Natalia Moskal, Naomi P. Visanji, Olena Gorbenko, Vijay Narasimhan, Hannah Tyrrell, Jess Nash, Peter N. Lewis, G. Angus McQuibban
Publikováno v:
PLoS Biology, Vol 21, Iss 3 (2023)
Failures in mitophagy, a process by which damaged mitochondria are cleared, results in neurodegeneration, while enhancing mitophagy promotes the survival of dopaminergic neurons. Using an artificial intelligence platform, we employed a natural langua
Externí odkaz:
https://doaj.org/article/afdab6f57e04423884c41f2a0a40427d
Autor:
Natalia Moskal, Victoria Riccio, Mikhail Bashkurov, Rediet Taddese, Alessandro Datti, Peter N. Lewis, G. Angus McQuibban
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Damaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged wit
Externí odkaz:
https://doaj.org/article/3e89b2ca7aa044dba87795668f0519b1
Autor:
Guang Shi, G. Angus McQuibban
Publikováno v:
Cell Reports, Vol 18, Iss 6, Pp 1458-1472 (2017)
Mitochondrial quality control (MQC) systems are essential for mitochondrial health and normal cellular function. Dysfunction of MQC is emerging as a central mechanism for the pathogenesis of various diseases, including Parkinson’s disease. The mamm
Externí odkaz:
https://doaj.org/article/25946113e3a54068b2c9d084a12bb84b
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 3 (2019)
In our recent publication, we describe a mechanism by which peroxisomes are protected from degradation by autophagy under basal conditions. Taking a page from mitophagy, peroxisomes also recruit the mitochondria deubiquitinating enzyme USP30 to count
Externí odkaz:
https://doaj.org/article/097a0d0e08344f3096ac103694491f3c
Autor:
Andrew R. Burns, Genna M. Luciani, Gabriel Musso, Rachel Bagg, May Yeo, Yuqian Zhang, Luckshi Rajendran, John Glavin, Robert Hunter, Elizabeth Redman, Susan Stasiuk, Michael Schertzberg, G. Angus McQuibban, Conor R. Caffrey, Sean R. Cutler, Mike Tyers, Guri Giaever, Corey Nislow, Andy G. Fraser, Calum A. MacRae, John Gilleard, Peter J. Roy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f372221257b04ca99777a3b815bb1dd0
Publikováno v:
Parkinson's Disease, Vol 2012 (2012)
Mitochondria are highly dynamic organelles that are important for many diverse cellular processes, such as energy metabolism, calcium buffering, and apoptosis. Mitochondrial biology and dysfunction have recently been linked to different types of canc
Externí odkaz:
https://doaj.org/article/f0bf6ae84be1457ebf175b964fa7018d
Autor:
Gao, Jie, Chau, Sabrina, Chowdhury, Fuad, Zhou, Tina, Hossain, Saif, McQuibban, G. Angus, Meneghini, Marc D.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2019 Aug . 116(33), 16454-16462.
Externí odkaz:
https://www.jstor.org/stable/26850438
Publikováno v:
In BBA - Molecular and Cell Biology of Lipids April 2018 1863(4):447-457