Zobrazeno 1 - 10 of 156 pro vyhledávání: '"G. Achen"'
1
Akademický článek
Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling
Autor: Vinochani Pillay, Lipi Shukla, Prad Herle, Simon Maciburko, Nadeeka Bandara, Isabella Reid, Steven Morgan, Yinan Yuan, Jennii Luu, Karla J. Cowley, Susanne Ramm, Kaylene J. Simpson, Marc G. Achen, Steven A. Stacker, Ramin Shayan, Tara Karnezis
Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Surgery and radiotherapy are key cancer treatments and the leading causes of damage to the lymphatics, a vascular network critical to fluid homeostasis and immunity. The clinical manifestation of this damage constitutes a devastating si
Externí odkaz: https://doaj.org/article/606001842ee84fea84121c90aaec3c6e
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2
Akademický článek
Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
Autor: Michael Y. He, Michael M. Halford, Ruofei Liu, James P. Roy, Zoe L. Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A. Dawson, Marc G. Achen, Steven A. Stacker
Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Through three-dimensional CRISPR screening, He et al. report that functional inhibition of BET family of proteins BRD2/3/4 shows mitigating effects on blood endothelial cell (EC) survival and/or proliferation upon VEGFA blockade. An interaction betwe
Externí odkaz: https://doaj.org/article/0a802170899b49c7b97c4550e22321e7
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3
Akademický článek
Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis
Autor: Adam J. Vogrin, Neil I. Bower, Menachem J. Gunzburg, Sally Roufail, Kazuhide S. Okuda, Scott Paterson, Stephen J. Headey, Steven A. Stacker, Benjamin M. Hogan, Marc G. Achen
Publikováno v: Cell Reports, Vol 28, Iss 8, Pp 2023-2036.e4 (2019)
Summary: Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all sett
Externí odkaz: https://doaj.org/article/4ff63854e2ad428099b435bfa53eb1db
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4
Akademický článek
Modulation of Immunity by Lymphatic Dysfunction in Lymphedema
Autor: Yinan Yuan, Valeria Arcucci, Sidney M. Levy, Marc G. Achen
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
The debilitating condition known as secondary lymphedema frequently occurs after lymphadenectomy and/or radiotherapy for the treatment of cancer. These therapies can damage lymphatic vessels leading to edema, fibrosis, inflammation and dysregulated a
Externí odkaz: https://doaj.org/article/32257a7dabb449ed925ab659e9d33e6c
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10
Data from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Autor: Steven A. Stacker, Marc G. Achen, Cameron J. Nowell, Masataka Matsumoto, Ramin Shayan, Tara Karnezis, Rae H. Farnsworth
Lymph node metastasis, an early and prognostically important event in the progression of many human cancers, is associated with expression of VEGF-D. Changes to lymph node vasculature that occur during malignant progression may create a metastatic ni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5da0df27bd3a30447e1016f36a54b1c
https://doi.org/10.1158/0008-5472.c.6503127.v1
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