Zobrazeno 1 - 10
of 41
pro vyhledávání: '"G. Aaron Hobbs"'
Autor:
Zhiwei Bian, Menny M. Benjamin, Lucas Bialousow, Yintai Tian, G. Aaron Hobbs, Dev Karan, Yeun-Mun Choo, Mark T. Hamann, Xiaojuan Wang
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33204- (2024)
Sine oculis homeoprotein 1 (SIX1), a prominent representative of the homeodomain transcription factors within the SIX family, has attracted significant interest owing to its role in tumorigenesis, cancer progression, and prognostic assessments. Initi
Externí odkaz:
https://doaj.org/article/a201e0c4d5c54445b4f037ceae53416a
Autor:
Imran Khan, Akiko Koide, Mariyam Zuberi, Gayatri Ketavarapu, Eric Denbaum, Kai Wen Teng, J. Matthew Rhett, Russell Spencer-Smith, G. Aaron Hobbs, Ernest Ramsay Camp, Shohei Koide, John P. O'Bryan
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110322- (2022)
Summary: RAS guanosine triphosphatases (GTPases) are mutated in nearly 20% of human tumors, making them an attractive therapeutic target. Following our discovery that nucleotide-free RAS (apo RAS) regulates cell signaling, we selectively target this
Externí odkaz:
https://doaj.org/article/c9a4430bc9ea408bb3a1d81302e52240
Autor:
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109291- (2021)
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative a
Externí odkaz:
https://doaj.org/article/24ff658919d8494e80b28117e73c541b
Autor:
Channing J. Der, Adrienne D. Cox, Udo Rudloff, Krister Wennerberg, Brian M. Wolpin, Andrew J. Aguirre, Dhirendra K. Simanshu, Emanuel F. Petricoin, Sharon L. Campbell, Dominic Esposito, Kirsten L. Bryant, Prson Gautam, Raymond W.S. Ng, Junning Wang, Jonathan M. DeLiberty, Craig M. Goodwin, Jennifer E. Klomp, Richard G. Hodge, Bjoern Papke, J. Nathaniel Diehl, Andrew M. Waters, Andrew O. Anderson, Timothy H. Tran, Mariaelena Pierobon, Ryan D. Thurman, Anne M. Miermont, Nicole M. Baker, G. Aaron Hobbs
Structure factors and crystal information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216f6e8c4cf83b25972bc99b461169ca
https://doi.org/10.1158/2159-8290.22535650
https://doi.org/10.1158/2159-8290.22535650
Autor:
Adrienne D. Cox, Channing J. Der, Emanuel F. Petricoin, Kris C. Wood, G. Aaron Hobbs, J. Nathaniel Diehl, Kathryn N. Lambert, Andrew M. Waters, Da'Jhnae Gambrell-Sanders, Mariaelena Pierobon, Frances L. Massey, Victoria V. Nguyen, Craig M. Goodwin, Antje Schaefer, Sehrish Javaid
Supplementary Table from Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af920e77927c4e8025b959ab08c7032
https://doi.org/10.1158/1535-7163.22522299
https://doi.org/10.1158/1535-7163.22522299
Autor:
Adrienne D. Cox, Channing J. Der, Emanuel F. Petricoin, Kris C. Wood, G. Aaron Hobbs, J. Nathaniel Diehl, Kathryn N. Lambert, Andrew M. Waters, Da'Jhnae Gambrell-Sanders, Mariaelena Pierobon, Frances L. Massey, Victoria V. Nguyen, Craig M. Goodwin, Antje Schaefer, Sehrish Javaid
Supplementary Data from Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1e2d68c6ccd0a9bc7874fcb47f0517
https://doi.org/10.1158/1535-7163.22522308.v1
https://doi.org/10.1158/1535-7163.22522308.v1
Autor:
Channing J. Der, Adrienne D. Cox, Udo Rudloff, Krister Wennerberg, Brian M. Wolpin, Andrew J. Aguirre, Dhirendra K. Simanshu, Emanuel F. Petricoin, Sharon L. Campbell, Dominic Esposito, Kirsten L. Bryant, Prson Gautam, Raymond W.S. Ng, Junning Wang, Jonathan M. DeLiberty, Craig M. Goodwin, Jennifer E. Klomp, Richard G. Hodge, Bjoern Papke, J. Nathaniel Diehl, Andrew M. Waters, Andrew O. Anderson, Timothy H. Tran, Mariaelena Pierobon, Ryan D. Thurman, Anne M. Miermont, Nicole M. Baker, G. Aaron Hobbs
All supplemental data with figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af433484762ea35ed3daf8e992a67bb1
https://doi.org/10.1158/2159-8290.22535653.v1
https://doi.org/10.1158/2159-8290.22535653.v1
Autor:
Minh V, Huynh, G Aaron, Hobbs, Antje, Schaefer, Mariaelena, Pierobon, Leiah M, Carey, J Nathaniel, Diehl, Jonathan M, DeLiberty, Ryan D, Thurman, Adelaide R, Cooke, Craig M, Goodwin, Joshua H, Cook, Lin, Lin, Andrew M, Waters, Naim U, Rashid, Emanuel F, Petricoin, Sharon L, Campbell, Kevin M, Haigis, Diane M, Simeone, Costas A, Lyssiotis, Adrienne D, Cox, Channing J, Der
Publikováno v:
Sci Signal
Although oncogenic driver mutations in RAS occur in 20% of cancers, heterogeneity in the biologic outputs of different RAS mutants has hampered efforts to develop effective treatments for RAS-mutated cancers. In this issue of Science Signaling, Huynh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::902a36258802379ec4087c4e0daa0e25
https://pubmed.ncbi.nlm.nih.gov/35944067
https://pubmed.ncbi.nlm.nih.gov/35944067
Autor:
Minh V. Huynh, G. Aaron Hobbs, Antje Schaefer, Mariaelena Pierobon, Leiah M. Carey, J. Nathaniel Diehl, Jonathan M. DeLiberty, Ryan D. Thurman, Adelaide R. Cooke, Craig M. Goodwin, Joshua H. Cook, Lin Lin, Andrew M. Waters, Naim U. Rashid, Emanuel F. Petricoin, Sharon L. Campbell, Kevin M. Haigis, Diane M. Simeone, Costas A. Lyssiotis, Adrienne D. Cox, Channing J. Der
Publikováno v:
Science Signaling. 15
Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS—Gly 12 , Gly 13 , and Gln 61 (commonly known as G12, G13, and Q61, respectively)—occur differentially among the three RAS isoforms. Q61 mutations in KRAS are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a3b4c161cea4d936e027bb855de402
https://doi.org/10.1126/scisignal.abn2694
https://doi.org/10.1126/scisignal.abn2694
Abstract B023: Inhibition of RAS signaling and tumorigenesis through targeting novel vulnerabilities
Autor:
Imran Kahn, Akiko Koide, Mariyam Zuberi, Gayatri Ketavarapu, Eric Denbaum, Kai Wen Teng, J. Matthew Rhett, Russell Spencer-Smith, G. Aaron Hobbs, Earnest Ramsay Camp, Shohei Koide, John P. O'Bryan
Publikováno v:
Molecular Cancer Research. 21:B023-B023
RAS GTPases are important mediators of oncogenesis with nearly 30% of human tumors harboring mutant RAS proteins. However, pharmacological inhibition of RAS has proven challenging. We have employed Monobody technology to discover novel vulnerabilitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e59dc84a8514a1c5bd262386625793a9
https://doi.org/10.1158/1557-3125.ras23-b023
https://doi.org/10.1158/1557-3125.ras23-b023