Zobrazeno 1 - 10
of 56
pro vyhledávání: '"G. A. Nickols"'
Publikováno v:
Hepatology Communications, Vol 4, Iss 5, Pp 696-707 (2020)
Hyperactivation of sterol regulatory element binding protein 1c (SREBP‐1c), which transcriptionally induces expression of enzymes responsible for de novo lipogenesis and triglyceride (TG) formation, is implicated in nonalcoholic fatty liver disease
Externí odkaz:
https://doaj.org/article/36e9ccb411ce4f4aa84ef8c4fe7afdf7
Autor:
Xiaoying Wu, Donna Romero, Wojciech I. Swiatek, Irene Dorweiler, Chintan K. Kikani, Hana Sabic, Ben S. Zweifel, John McKearn, Jeremy T. Blitzer, G. Allen Nickols, Jared Rutter
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 242-255 (2014)
Elevated hepatic synthesis of fatty acids and triglycerides, driven by hyperactivation of the SREBP-1c transcription factor, has been implicated as a causal feature of metabolic syndrome. SREBP-1c activation requires the proteolytic maturation of the
Externí odkaz:
https://doaj.org/article/bcfb358796ac4baaa0adfe00f7c46801
Autor:
Hana Sabic, Jeremy Blitzer, Xiaoying Wu, Wojciech I. Swiatek, Jared Rutter, John Mckearn, Ben S. Zweifel, Irene Dorweiler, Donna L. Romero, G. Allen Nickols, Chintan K. Kikani
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 242-255 (2014)
SummaryElevated hepatic synthesis of fatty acids and triglycerides, driven by hyperactivation of the SREBP-1c transcription factor, has been implicated as a causal feature of metabolic syndrome. SREBP-1c activation requires the proteolytic maturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d919285da38bca54633637b8472be1bf
https://doi.org/10.1016/j.celrep.2014.06.006
https://doi.org/10.1016/j.celrep.2014.06.006
Publikováno v:
Journal of Bone and Mineral Research. 4:615-623
Parathyroid hormone (PTH) receptors have been described in renal tissue from several species, but not in the rat. In this study, radioligand binding techniques were used to identify and characterize PTH receptors in rat kidney cortical membranes. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd860d6128cfd7c1279b9342dd72643f
https://doi.org/10.1002/jbmr.5650040420
https://doi.org/10.1002/jbmr.5650040420
Autor:
James W. Malecha, Christina N. Steininger, Melanie L. Williams, Kristen E. Shannon, Thomas Rogers, Bryan H. Landis, Tiffany Duffin, Srinivasan Nagarajan, Pegg Jodi Ann, Hwang-Fun Lu, Rico Joseph G, Maureen A. Nickols, Jun Zhu, Sandra K. Freeman, V. Wayne Engleman, David W. Griggs, G. Alan Nickols, Jeffery L. Keene, Devadas Balekudru, Debra M. Meyer, Marisa M. Westlin, Larry Miller, Laura D. Marrufo, Nawasa F. Green, Melissa K. Lantz, Mark A. Russell, Peter G. Ruminski, Mary Beth Finn, H. Peter Kleine, Joe T. Collins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3783-3800
The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d38d74f8d90c225cd3716f76ef91f6
https://doi.org/10.1016/j.bmc.2007.03.034
https://doi.org/10.1016/j.bmc.2007.03.034
Autor:
Srinivasan Nagarajan, Ish K. Libertyville Khanna, Tiffany Duffin, Alan F. Gasiecki, Jeffery L. Keene, Mihir D. Parikh, Michael Clare, Marisa M. Westlin, Maureen A. Nickols, Christina A. Steininger, Melanie L. Williams, Hwang-Fun Lu, Thomas Rogers, Jon A. Klover, Mary Beth Finn, V. Wayne Engleman, Sandra K. Freeman, William F. Westlin, Barbara B. Chen, G. Alan Nickols, Kristen E. Shannon, Mark A. Russell, Bipinchandra N. Desai
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3390-3412
The integrin alpha(v)beta(3) is expressed in a number of cell types and is thought to play a major role in several pathological conditions. Various small molecules that inhibit the integrin have been shown to suppress tumor growth and retinal angioge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76977820b693cad5d5c26a6da2d6f596
https://doi.org/10.1016/j.bmc.2007.03.020
https://doi.org/10.1016/j.bmc.2007.03.020
Autor:
Tiffany Duffin, Maureen A. Nickols, Barbara B. Chen, Mary Beth Finn, Mark A. Russell, William F. Westlin, Steven L. Settle, Mark L. Boys, Randall K. Rader, Jon A. Klover, Wang Yaping, Thomas D. Penning, Jeffery L. Keene, V. Wayne Engleman, G. Allen Nickols, Christina N. Steininger, Sandra K. Freeman, Melanie L. Hanneke, Khilevich Albert, Marisa M. Westlin, Kristen E. Shannon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3156-3161
We describe a series of pyrazole and isoxazole analogs as antagonists of the α v β 3 receptor. Compounds showed low to sub-nanomolar potency against α v β 3 , as well as good selectivity against α IIb β 3 . In HT29 cells, most analogs also demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e27cd8fc7dca2f6785f6b7c08e8bda4
https://doi.org/10.1016/j.bmcl.2006.03.045
https://doi.org/10.1016/j.bmcl.2006.03.045
Autor:
Mary Beth Finn, Hongwei Wu, Kristen E. Shannon, V. Wayne Engleman, Maureen A. Nickols, Jon A. Klover, Marissa Westlin, Tiffany Duffin, Christina N. Steininger, G. Allen Nickols, Thomas D. Penning, Melanie L. Hanneke, John A. Wendt, Heather Stenmark, Mark A. Russell, Jeffery L. Keene, Downs Victoria Leigh, William F. Westlin, Barbara B. Chen, Wang Yaping, Sandra K. Freeman, Mark L. Boys
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:845-849
We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(v)beta3 and show selectivity relative to the other integrins, such as alpha(IIb)beta3 and alpha(v)beta6. These analogs were demonstrated to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9341668d602c5606e629cc594893da77
https://doi.org/10.1016/j.bmcl.2005.11.017
https://doi.org/10.1016/j.bmcl.2005.11.017
Autor:
Christopher R. Dalton, Nizal S. Chandrakumar, Mark L. Boys, G. Allen Nickols, Mark Russell, Maureen A. Nickols, Michael Clare, Dale P. Spangler, John A. Wendt, Christina N. Steininger, William F. Westlin, Yaping Wang, Tiffany Duffin, Michael B. Tollefson, Jon A. Klover, Sandra K. Freeman, Melanie L. Hanneke, Scott B. Mohler, Mary Beth Finn, Maria N. Nguyen, Heather G. Stenmark, Jeffery L. Keene, Hongwei Wu, Bipin N. Desai, Barbara B. Chen, V. Wayne Engleman, Yi X. Yu, Sarah A. Norring, Marisa M. Westlin, Lori A. Schretzman, Downs Victoria Leigh, Ish K. Khanna, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:839-844
We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha(v)beta3 and, in addition, show selectivity relative to the other beta3 integrin alpha(IIb)beta3. In whole cells, the majority of these analogs also demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701f9513e934e8bf576a289475c31d0e
https://doi.org/10.1016/j.bmcl.2005.11.008
https://doi.org/10.1016/j.bmcl.2005.11.008
Autor:
Srinivasan Nagarajan, G. Alan Nickols, Jon A. Klover, David W. Griggs, Sandra K. Freeman, V. Wayne Engleman, Jane M. Meyer, Julie M. Miyashiro
Publikováno v:
Chemical Biology Drug Design. 67:177-181
A peptidomimetic inhibitor of the integrin alpha(v)beta(3) has been substantially modified to produce several new nonpeptidic antagonists. These inhibitors are simpler to synthesize and belong to new classes of scaffolds. Some of the compounds served
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74e503ee22c7639bb7877f222849d45
https://doi.org/10.1111/j.1747-0285.2006.00344.x
https://doi.org/10.1111/j.1747-0285.2006.00344.x