Zobrazeno 1 - 10
of 1 236
pro vyhledávání: '"G. A. Hughes"'
Autor:
Byoung Chul Cho, Irene Braña, Beatriz Cirauqui, Sercan Aksoy, Felix Couture, Ruey-Long Hong, Wilson H. Miller, Manuel Chaves-Conde, Margarida Teixeira, Lance Leopold, Mihaela Munteanu, Joy Yang Ge, Ramona F. Swaby, Brett G. M. Hughes
Publikováno v:
BMC Cancer, Vol 23, Iss S1, Pp 1-12 (2024)
Abstract Background Advanced head and neck squamous cell carcinoma (HNSCC) has a poor prognosis, and new treatment options are needed. Combining immunotherapies with differing mechanisms of action may enhance clinical benefits compared with single-ag
Externí odkaz:
https://doaj.org/article/24bfd93adc7946a58a1c047c4d340cb7
Autor:
Åse Bratland, Eva Munoz-Couselo, Laurent Mortier, Osama Roshdy, Rene González, Jacob Schachter, Ana M. Arance, Florent Grange, Nicolas Meyer, Abhishek Jagdish Joshi, Salem Billan, Brett G. M. Hughes, Jean-Jacques Grob, Karthik Ramakrishnan, Joy Ge, Burak Gumuscu, Ramona F. Swaby, Ralf Gutzmer
Publikováno v:
Dermatology and Therapy, Vol 13, Iss 12, Pp 3165-3180 (2023)
Abstract Introduction At first interim analysis of KEYNOTE-629, health-related quality of life (HRQoL) with pembrolizumab was stable or improved over 48 weeks in recurrent or metastatic (R/M) cutaneous squamous cell carcinoma (cSCC). HRQoL results fr
Externí odkaz:
https://doaj.org/article/c25ae9485a674062bd066049630a8b43
Autor:
Dirk Schadendorf, Thomas K Eigentler, Israel Lowy, Apostolos Papachristos, Samantha Bowyer, Friedegund Meier, Brigitte Dreno, Danny Rischin, Michael R Migden, Annette M Lim, Chrysalyne D Schmults, Brett G M Hughes, Axel Hauschild, Brian Stein, Emmanuel Okoye, Jocelyn Booth, Matthew G Fury, Alexander Guminski, Sophie Dalac, Frank Seebach, Marie Beylot-Barry, Suk-Young Yoo, Nicole Basset-Séguin, Sabiha Trabelsi Messai, Victoria Casado Echarren, Anne J Paccaly, Jenny-Hoa Nguyen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Background Cemiplimab (Libtayo®), a human monoclonal immunoglobulin G4 antibody to the programmed cell death-1 receptor, is approved for the treatment of patients with advanced cutaneous squamous cell carcinoma (CSCC), who are not candidates for cur
Externí odkaz:
https://doaj.org/article/85c0508e98f2481db714933c819add16
Autor:
Matthew H. Taylor, Sophie Leboulleux, Yury Panaseykin, Bhavana Konda, Christelle de LaFouchardiere, Brett G. M. Hughes, Andrew G. Gianoukakis, Young Joo Park, Ilia Romanov, Monika K. Krzyzanowska, Diana Garbinsky, Bintu Sherif, Jie Janice Pan, Terri A. Binder, Nicholas Sauter, Ran Xie, Marcia S. Brose
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4332-4342 (2023)
Abstract Background In the phase 2 double‐blind Study 211, a starting dose of lenvatinib 18 mg/day was compared with the approved starting dose of 24 mg/day in patients with radioiodine‐refractory differentiated thyroid cancer (RR‐DTC). Predefi
Externí odkaz:
https://doaj.org/article/dc0ec1a8bab345c086c5e789e1eef9a5
Autor:
Habib Sadeghirad, Ning Liu, James Monkman, Ning Ma, Bassem Ben Cheikh, Niyati Jhaveri, Chin Wee Tan, Majid Ebrahimi Warkiani, Mark N. Adams, Quan Nguyen, Rahul Ladwa, Oliver Braubach, Ken O’Byrne, Melissa Davis, Brett G. M. Hughes, Arutha Kulasinghe
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mucosal head and neck squamous cell carcinoma (HNSCC) are the seventh most common cancer, with approximately 50% of patients living beyond 5 years. Immune checkpoint inhibitors (ICIs) have shown promising results in patients with recurrent or metasta
Externí odkaz:
https://doaj.org/article/deb6e95791cc45ce81a3059cd2e13bb7
Autor:
Thomas Marron, Brett G M Hughes, Jason John Luke, Shenshen Hu, Suresh Mahabhashyam, Richard A Miller, William B Jones, Jaime R Merchan, Stephen B Willingham
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background CD73 is widely expressed on immune cells playing a critical role in immunomodulatory functions including cell adhesion and migration, as a costimulatory molecule for T cells and in production of adenosine. The function of CD73 expressed on
Externí odkaz:
https://doaj.org/article/e01f803878c74d1d9d09ada0e739c0f0
Autor:
Habib Sadeghirad, James Monkman, Ahmed M. Mehdi, Rahul Ladwa, Ken O’Byrne, Brett G. M. Hughes, Arutha Kulasinghe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Head and neck squamous cell carcinoma (HNSCC) often presents with locoregional or distant disease, despite multimodal therapeutic approaches, which include surgical resection, chemoradiotherapy, and more recently, immunotherapy for metastatic or recu
Externí odkaz:
https://doaj.org/article/5034624ca5ae444e9dd5babcf7d03a81
Autor:
E. I. Patterson, G. Elia, A. Grassi, A. Giordano, C. Desario, M. Medardo, S. L. Smith, E. R. Anderson, T. Prince, G. T. Patterson, E. Lorusso, M. S. Lucente, G. Lanave, S. Lauzi, U. Bonfanti, A. Stranieri, V. Martella, F. Solari Basano, V. R. Barrs, A. D. Radford, U. Agrimi, G. L. Hughes, S. Paltrinieri, N. Decaro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
SARS-CoV-2 can infect cats and dogs, but the extent to which pets are infected in households remains unclear. Here, Patterson et al. test 919 companion animals in northern Italy and find that some dogs and cats from COVID-19 positive households can t
Externí odkaz:
https://doaj.org/article/c3a19324015f4c1eaa9f8aecfb8c4d58
Publikováno v:
Journal of Head & Neck Physicians and Surgeons, Vol 8, Iss 1, Pp 17-22 (2020)
Introduction: Incidental pulmonary nodule(s) (IPNs) are a common finding during staging imaging for the head-and-neck squamous cell cancers (HNSCC) treated with curative intent. Currently, the incidence of metastasis or synchronous malignancies and o
Externí odkaz:
https://doaj.org/article/cc7e28b8b4da4ce5950c736cd4d7664b
Autor:
Elizabeth Ahern, Annette Cubitt, Emma Ballard, Michele W. L. Teng, William C. Dougall, Mark J. Smyth, David Godbolt, Rishendran Naidoo, Amanda Goldrick, Brett G. M. Hughes
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Neoadjuvant immunotherapy targeting immune checkpoint programmed death-1 (PD-1) is under investigation in various tumour settings including non-small-cell lung cancer (NSCLC). Preclinical models demonstrate the superior power of t
Externí odkaz:
https://doaj.org/article/9117ce33194c46a382e8341cd7f4cfdf