Zobrazeno 1 - 10
of 27
pro vyhledávání: '"G. A. Homandberg"'
Publikováno v:
Journal of Orthopaedic Research. 32:811-818
Post-traumatic osteoarthritis (PTOA) is characterized by progressive cartilage degeneration in injured joints. Since fibronectin-fragments (Fn-fs) degrade cartilage mainly through up-regulating matrix metalloproteinases (MMPs) and pro-inflammatory cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e4dd91f20c574d9180ccf7b15767ad1
https://doi.org/10.1002/jor.22610
https://doi.org/10.1002/jor.22610
Autor:
N. J. Stroud, N. Nicholson, Lei Ding, Danping Guo, Emily Heying, Joseph A. Buckwalter, G. A. Homandberg, James A. Martin
Publikováno v:
Osteoarthritis and Cartilage. 18:1509-1517
Summary Objective To determine the activation of Mitogen activated protein (MAP) kinases in and around cartilage subjected to mechanical damage and to determine the effects of their inhibitors on impaction-induced chondrocyte death and cartilage dege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7cbe177ab3bd0e500741b25343a0d7
https://doi.org/10.1016/j.joca.2010.08.014
https://doi.org/10.1016/j.joca.2010.08.014
Publikováno v:
Inflammation Research. 58:161-169
We hypothesize that N-telopeptide (NT) and C-telopeptides (CT) of type II collagen can enhance proteinases and cause cartilage damage and have compared damaging activities to an extensively characterized potent fibronectin fragment (Fn-f).NT and CT p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c635960e9ef2c5dd73ed31eb7ef0972b
https://doi.org/10.1007/s00011-009-8090-5
https://doi.org/10.1007/s00011-009-8090-5
Publikováno v:
Osteoarthritis and Cartilage. 16(10):1253-1262
Summary Objective To define the role of mitogen activated protein (MAP) kinases in fibronectin fragment (Fn-f) mediated matrix metalloproteinase (MMP) upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8abba68a709ee24347c6230a81ba25e
Publikováno v:
Current Rheumatology Reviews. 3:183-196
It is now firmly established that fragments of extracellular matrix (ECM) macromolecules that arise from the damaged ECM have the ability to regulate chondrocyte metabolism and enhance the degradative processes. Fibronectin fragments (Fn-fs), type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff601f8f88e14c63afa1bc388ee2ebb
https://doi.org/10.2174/157339707781387590
https://doi.org/10.2174/157339707781387590
Autor:
G. A. Homandberg
Publikováno v:
Current Rheumatology Reviews. 2:23-30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e37aafb0f812b5a4cfff650c50a7a65c
https://doi.org/10.2174/157339706775696973
https://doi.org/10.2174/157339706775696973
Publikováno v:
Archives of Biochemistry and Biophysics. 307:110-118
We reported earlier that fibronectin fragments (Fn-f) added to bovine articular cartilage cultured in serum-free culture causes marked protease expression with resultant proteoglycan (PG) degradation and release into the culture media. We have furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3298e02171e9244a1ed2dd6528ca2f
https://doi.org/10.1006/abbi.1993.1568
https://doi.org/10.1006/abbi.1993.1568
Autor:
S.S. Rai, R.M. Schulz, G. A. Homandberg, N. Wuestneck, A. Bader, C. Thuemmler, Tina T. Chowdhury
Publikováno v:
Osteoarthritis and Cartilage. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59a335dc6042cae5a076de7a4a3ff11
Publikováno v:
Osteoarthritis and cartilage. 17(10)
Summary Objective Since fibronectin fragments (Fn-fs) enhance cartilage damage through integrins, the objective was to investigate the role of integrin linked kinases, focal adhesion kinase (FAK) and a soluble form of FAK, proline rich tyrosine kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3665b7f53079666fc9868661b6dcbd97
https://pubmed.ncbi.nlm.nih.gov/19409294
https://pubmed.ncbi.nlm.nih.gov/19409294
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 53(10)
To determine whether the ability of high molecular weight hyaluronan (HA) to reverse cartilage damage caused by specific catabolic mediators of cartilage damage, fibronectin fragments (Fn-fs), occurs through a low grade of enhanced catabolic events s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb2d65d480f4672000a5b15bc2126c7
https://pubmed.ncbi.nlm.nih.gov/15597148
https://pubmed.ncbi.nlm.nih.gov/15597148