Výsledky vyhledávání - "G. A. HEAVNER"

Peptides Derived from the Lectin Domain of Selectin Adhesion Molecules Inhibit Leukocyte Rolling In Vivo

Autor: Eric J. Kunkel, C. Scheding, Keith E. Norman, Klaus Ley, G. A. Heavner

Publikováno v: Microcirculation. 3:29-38

The selectins are a family of adhesion molecules that mediate leukocyte rolling, a prerequisite for their later firm adhesion and migration to sites of inflammation. The N-terminal lectin domain of selectins is important for Ca(2+)-dependent binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6104a8a568abe569e426ac054227d4
https://doi.org/10.3109/10739689609146780

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A synthetic peptide approach for elucidating the points of natural auto-antibody reactivity to proteolytic fragments of human IgG

Autor: A, Schmidt, D, DeRiggi, R E, Jordan, B, Whitaker, G A, Heavner, M, Kruszynski

Publikováno v: Advances in experimental medicine and biology. 611

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a17abf869123115bdb6b63c811d250e
https://pubmed.ncbi.nlm.nih.gov/19400244

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A Synthetic Peptide Approach for Elucidating the Points of Natural Auto-Antibody Reactivity to Proteolytic Fragments of Human IgG

Autor: B. Whitaker, Marian Kruszynski, R. E. Jordan, D. De Riggi, A. Schmidt, G. A. Heavner

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9780387736563

Introduction There are naturally occurring human antibodies to the F(ab’)2 portion of IgG [1]. Extracellular proteases and bacterial enzymes can cleave the IgG hinge region and release the Fc domain (with its effector functions. The human immune re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fc4ba6bb3ab8258d92e7850c0281ecc
https://doi.org/10.1007/978-0-387-73657-0_177

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Structure-function analysis of LPS neutralizing synthetic peptides derived from human LPS binding protein

Autor: A. H. Taylor, G. A. Heavner, M. Nedelman, D. Knight, J. Ghrayeb, E. Brunt, D. Sherris

Publikováno v: Peptides 1994 ISBN: 9789072199218
Peptides 1994

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::966b4aa7e04cd6b38e00c1e96bc0cfe1
https://doi.org/10.1007/978-94-011-1468-4_298

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Lectin domain peptides from selectins interact with both cell surface ligands and Ca2+ ions

Autor: J G, Geng, G A, Heavner, R P, McEver

Publikováno v: The Journal of biological chemistry. 267(28)

Selectins are receptors that mediate leukocyte adhesion to platelets or endothelial cells through Ca(2+)-dependent interactions with cell surface oligosaccharides. We found that peptides corresponding to residues 23-30, 54-63, and 70-79 of the N-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e781cd68b9dcc3c78545621671acaab
https://pubmed.ncbi.nlm.nih.gov/1383198

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Pharmacokinetics and Pharmacodynamics of CNTO 528, a Novel Erythropoietin Receptor Agonist in Normal and Anemic Rats

Autor: Ian E. James, Bernard Scallon, E. Eirikis, Paul W. Fisher, K. Shamberger, G. A. Heavner, Peter Bugelski, Chichi Huang, T. Spinka-Doms, J. Ghrayeb, C. Pool, Dorie Makropoulos, H. Jang, Thomas Nesspor, Josie Fisher, D. B. Knight, Amy L. Volk, B. Miller

Publikováno v: Blood. 106:4261-4261

CNTO 528 is a member of a group of novel stimulants of erythropoiesis that has recently entered clinical trials. Although CNTO 528 bears no sequence homology to erythropoietin (EPO), it is an EPO receptor agonist, capable of rescuing EPO-dependent ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c23f38df5a9f3eca3e10b74c1216706
https://doi.org/10.1182/blood.v106.11.4261.4261

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Akademický článek

Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab.

Autor: Yoshikawa, Moeka¹ (AUTHOR), Nakamura, Hitomi¹ (AUTHOR), Oda-Ueda, Naoko¹ (AUTHOR), Ohkuri, Takatoshi¹ (AUTHOR) ohkuri@ph.sojo-u.ac.jp

Publikováno v: Journal of Biochemistry. Oct2023, Vol. 174 Issue 4, p345-353. 9p.

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Akademický článek

The MOE Modification of RNA: Origins and Widescale Impact on the Oligonucleotide Therapeutics Field.

Autor: Hill, Alyssa C.¹ (AUTHOR), Hall, Jonathan¹ (AUTHOR) jonathan.hall@pharma.ethz.ch

Publikováno v: Helvetica Chimica Acta. Mar2023, Vol. 106 Issue 3, p1-15. 15p.

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ChemInform Abstract: IMPROVED PREPARATION OF 4-(BOC-AMINOACYLOXYMETHYL)-PHENYLACETIC ACIDS FOR USE IN PEPTIDE SYNTHESIS ON SOLID SUPPORTS UTILIZING A PROTECTING GROUP REMOVABLE BY PHOTOLYSIS OR REDUCTION

Autor: F. S. TJOENG, G. A. HEAVNER

Publikováno v: Chemischer Informationsdienst. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2dbca35a7246954f099d87c9e335f9da
https://doi.org/10.1002/chin.198211340

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Developmental and behavioral effects of early postnatal exposure to triethyltin in rats

Autor: L W, Reiter, G B, Heavner, K F, Dean, P H, Ruppert

Publikováno v: Neurobehavioral toxicology and teratology. 3(3)

On Day 5 of postnatal life, rat pups received a single injection of triethyltin and were later tested for a variety of developmental and adult behaviors. A within-litter dosing design was used with one male and one female from each litter (N = 8 pups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bacb21c07a3d01ededd0987f9b296f01
https://pubmed.ncbi.nlm.nih.gov/7290284

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