A droplet-based microfluidic platform enables high-throughput combinatorial optimization of cyanobacterial cultivation

Autor: Jialan Cao, David A. Russo, Ting Xie, G. Alexander Groß, Julie A. Z. Zedler

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Cyanobacteria are fast-growing, genetically accessible, photoautotrophs. Therefore, they have attracted interest as sustainable production platforms. However, the lack of techniques to systematically optimize cultivation parameters in a high

Externí odkaz: https://doaj.org/article/0b42fbf9f1584c74b638f64ed2c81a0e

Automated Analysis of Acetaminophen Toxicity on 3D HepaRG Cell Culture in Microbioreactor

Autor: Martin Baca, Dana Brauer, Maren Klett, Uta Fernekorn, Sukhdeep Singh, Jörg Hampl, G. Alexander Groß, Patrick Mai, Karin Friedel, Andreas Schober

Publikováno v: Bioengineering, Vol 9, Iss 5, p 196 (2022)

Real-time monitoring of bioanalytes in organotypic cell cultivation devices is a major research challenge in establishing stand-alone diagnostic systems. Presently, no general technical facility is available that offers a plug-in system for bioanalyt

Externí odkaz: https://doaj.org/article/b8dd41b1b138467297de882a3a1c1f55

2021 Canadian Surgery Forum01. Design and validation of a unique endoscopy simulator using a commercial video game03. Is ethnicity an appropriate measure of health care marginalization?: A systematic review and meta-analysis of the outcomes of diabetic foot ulceration in the Aboriginal population04. Racial disparities in surgery — a cross-specialty matched comparison between black and white patients05. Starting late does not increase the risk of postoperative complications in patients undergoing common general surgical procedures06. Ethical decision-making during a health care crisis: a resource allocation framework and tool07. Ensuring stability in surgical training program leadership: a survey of program directors08. Introducing oncoplastic breast surgery in a community hospital09. Leadership development programs for surgical residents: a review of the literature10. Superiority of non-opioid postoperative pain management after thyroid and parathyroid operations: a systematic review and meta-analysis11. Timing of ERCP relative to cholecystectomy in patients with ductal gallstone disease12. A systematic review and meta-analysis of randomized controlled trials comparing intraoperative red blood cell transfusion strategies13. Postoperative outcomes after frail elderly preoperative assessment clinic: a single-institution Canadian perspective14. Selective opioid antagonists following bowel resection for prevention of postoperative ileus: a systematic review and meta-analysis15. Peer-to-peer coaching after bile duct injury16. Laparoscopic median arcuate ligament release: a video abstract17. Retroperitoneoscopic approach to adrenalectomy19. Endoscopic Zenker diverticulotomy: a video abstract20. Variability in surgeons’ perioperative management of pheochromocytomas in Canada21. The contribution of surgeon and hospital variation in transfusion practice to outcomes for patients undergoing elective gastrointestinal cancer surgery: a population-based analysis22. Perioperative transfusions for gastroesophageal cancers: risk factors and short- and long-term outcomes23. The association between frailty and time alive and at home after cancer surgery among older adults: a population-based analysis24. Psychological and workplace-related effects of providing surgical care during the COVID-19 pandemic in British Columbia, Canada25. Safety of venous thromboembolism prophylaxis in endoscopic retrograde cholangiopancreatography: a systematic review26. Complications and reintervention following laparoscopic subtotal cholecystectomy: a systematic review and meta-analysis27. Synchronization of pupil dilations correlates with team performance in a simulated laparoscopic team coordination task28. Receptivity to and desired design features of a surgical peer coaching program: an international survey9. Impact of the COVID-19 pandemic on rates of emergency department utilization due to general surgery conditions30. The impact of the current COVID-19 pandemic on the exposure of general surgery trainees to operative procedures31. Association between academic degrees and research productivity: an assessment of academic general surgeons in Canada32. Laparoscopic endoscopic cooperative surgery (LECS) for subepithelial gastric lesion: a video presentation33. Effect of the COVID-19 pandemic on acute care general surgery at an academic Canadian centre34. Opioid-free analgesia after outpatient general surgery: a pilot randomized controlled trial35. Impact of neoadjuvant immunotherapy or targeted therapies on surgical resection in patients with solid tumours: a systematic review and meta-analysis37. Surgical data recording in the operating room: a systematic review of modalities and metrics38. Association between nonaccidental trauma and neighbourhood socioeconomic status during the COVID-19 pandemic: a retrospective analysis39. Laparoscopic repair of a transdiaphragmatic gastropleural fistula40. Video-based interviewing in medicine: a scoping review41. Indocyanine green fluorescence angiography for prevention of anastomotic leakage in colorectal surgery: a cost analysis from the hospital payer’s perspective43. Perception or reality: surgical resident and faculty assessments of resident workload compared with objective data45. When illness and loss hit close to home: Do health care providers learn how to cope?46. Remote video-based suturing education with smartphones (REVISE): a randomized controlled trial47. The evolving use of robotic surgery: a population-based analysis48. Prophylactic retromuscular mesh placement for parastomal hernia prevention: a retrospective cohort study of permanent colostomies and ileostomies49. Intracorporeal versus extracorporeal anastomosis in laparoscopic right hemicolectomy: a retrospective cohort study on anastomotic complications50. A lay of the land — a description of Canadian academic acute care surgery models51. Emergency general surgery in Ontario: interhospital variability in structures, processes and models of care52. Trauma 101: a virtual case-based trauma conference as an adjunct to medical education53. Assessment of the National Surgical Quality Improvement Program Surgical Risk Calculator for predicting patient-centred outcomes of emergency general surgery patients in a Canadian health care system54. Sustainability of a narcotic reduction initiative: 1 year following the Standardization of Outpatient Procedure (STOP) Narcotics Study55. Barriers to transanal endoscopic microsurgery referral56. Geospatial analysis of severely injured rural patients in a geographically complex landscape57. Implementation of an incentive spirometry protocol in a trauma ward: a single-centre pilot study58. Impostor phenomenon is a significant risk factor for burnout and anxiety in Canadian resident physicians: a cross-sectional survey59. Understanding the influence of perioperative education on performance among surgical trainees: a single-centre experience60. The effect of COVID-19 pandemic on current and future endoscopic personal protective equipment practices: a national survey of 77 endoscopists61. Case report: delayed presentation of perforated sigmoid diverticulitis as necrotizing infection of the lower limb62. Investigating disparities in surgical outcomes in Canadian Indigenous populations63. Fundoplication is superior to medical therapy for Barrett esophagus disease regression and progression: a systematic review and meta-analysis64. Development of a novel online general surgery learning platform and a qualitative preimplementation analysis65. Hagfish slime exudate as a potential novel hemostatic agent: developing a standardized assessment protocol66. The effect of the first wave of the COVID-19 pandemic on surgical oncology case volumes and wait times67. Safety of same-day discharge in high-risk patients undergoing ambulatory general surgery68. External validation of the Codman score in colorectal surgery: a pragmatic tool to drive quality improvement69. Improved morbidity and gastrointestinal restoration rates without compromising survival rates for diverting loop ileostomy with colonic lavage versus total abdominal colectomy for fulminant Clostridioides difficile colitis: a multicentre retrospective cohort study70. Potential access to emergency general surgical care in Ontario71. Immersive virtual reality (iVR) improves procedural duration, task completion and accuracy in surgical trainees: a systematic review01. Clinical validation of the Canada Lymph Node Score for endobronchial ultrasound02. Venous thromboembolism in surgically treated esophageal cancer patients: a provincial population-based study03. Venous thromboembolism in surgically treated lung cancer patients: a population-based study04. Is frailty associated with failure to rescue after esophagectomy? A multi-institutional comparative analysis of outcomes05. Routine systematic sampling versus targeted sampling of lymph nodes during endobronchial ultrasound: a feasibility randomized controlled trial06. Gastric ischemic conditioning reduces anastomotic complications in patients undergoing esophagectomy: a systematic review and meta-analysis07. Move For Surgery, a novel preconditioning program to optimize health before thoracic surgery: a randomized controlled trial08. In case of emergency, go to your nearest emergency department — Or maybe not?09. Does preoperative SABR increase the risk of complications from lung cancer resection? A secondary analysis of the MISSILE trial10. Segmental resection for lung cancer: the added value of near-infrared fluorescence mapping diminishes with surgeon experience11. Toward competency-based continuing professional development for practising surgeons12. Stereotactic body radiotherapy versus surgery in older adults with NSCLC — a population-based, matched analysis of long-term dependency outcomes13. Role of adjuvant therapy in esophageal cancer patients after neoadjuvant therapy and curative esophagectomy: a systematic review and meta-analysis14. Evaluation of population characteristics on the incidence of thoracic empyema: an ecological study15. Determining the optimal stiffness colour threshold and stiffness area ratio cut-off for mediastinal lymph node staging using EBUS elastography and AI: a pilot study16. Quality assurance on the use of sequential compression stockings in thoracic surgery (QUESTs)17. The relationship between fissureless technique and prolonged air leak for patients undergoing video-assisted thoracoscopic lobectomy18. CXCR2 inhibition as a candidate for immunomodulation in the treatment of K-RAS-driven lung adenocarcinoma19. Assessment tools for evaluating competency in video-assisted thoracoscopic lobectomy: a systematic review20. Understanding the current practice on chest tube management following lung resection among thoracic surgeons across Canada21. Effect of routine jejunostomy tube insertion in esophagectomy: a systematic review and meta-analysis22. Recurrence of primary spontaneous pneumothorax following bullectomy with pleurodesis or pleurectomy: a retrospective analysis23. Surgical outcomes following chest wall resection and reconstruction24. Outcomes following surgical management of primary mediastinal nonseminomatous germ cell tumours25. Does robotic approach offer better nodal staging than thoracoscopic approach in anatomical resection for non–small cell lung cancer? A single-centre propensity matching analysis26. Competency assessment for mediastinal mass resection and thymectomy: design and Delphi process27. The contemporary significance of venous thromboembolism (deep venous thrombosis [DVT] and pulmonary embolus [PE]) in patients undergoing esophagectomy: a prospective, multicentre cohort study to evaluate the incidence and clinical outcomes of VTE after major esophageal resections28. Esophageal cancer: symptom severity at the end of life29. The impact of pulmonary artery reconstruction on postoperative and oncologic outcomes: a systematic review30. Association with surgical technique and recurrence after laparoscopic repair of paraesophageal hernia: a single-centre experience31. Enhanced recovery after surgery (ERAS) in esophagectomy32. 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Posterior mesorectal thickness as a predictor of increased operative time in rectal cancer surgery: a retrospective cohort study09. Improvement of colonic anastomotic healing in mice with oral supplementation of oligosaccharides10. How can we better identify patients with rectal bleeding who are at high risk of colorectal cancer?11. Assessment of long-term bowel dysfunction in rectal cancer survivors: a population-based cohort study12. Observational versus antibiotic therapy for acute uncomplicated diverticulitis: a noninferiority meta-analysis based on a Delphi consensus13. Radiotherapy alone versus chemoradiotherapy for stage I anal squamous cell carcinoma: a systematic review and meta-analysis14. Is the Hartmann procedure for diverticulitis obsolete? National trends in colectomy for diverticulitis in the emergency setting from 1993 to 201515. Sugammadex in colorectal surgery: a systematic review and meta-analysis16. Sexuality and rectal cancer treatment: a qualitative study exploring patients’ information needs and expectations on sexual dysfunction after rectal cancer treatment17. Video-based interviews in selection process18. Impact of delaying colonoscopies during the COVID-19 pandemic on colorectal cancer detection and prevention19. Opioid use disorder associated with increased anastomotic leak and major complications after colorectal surgery20. Effectiveness of a rectal cancer education video on patient expectations21. Robotic-assisted rectosigmoid and rectal cancer resection: implementation and early experience at a Canadian tertiary centre22. An online educational app for rectal cancer survivors with low anterior resection syndrome: a pilot study23. The effects of surgeon specialization on the outcome of emergency colorectal surgery24. Outcomes after colorectal cancer resections in octogenarians and older in a regional New Zealand setting — What are the predictors of mortality?25. Long-term outcomes after seton placement for perianal fistulae with and without Crohn disease26. A survey of patient and surgeon preference for early ileostomy closure following restorative proctectomy for rectal cancer — Why aren’t we doing it?27. Crohn disease independently associated with longer hospital admission after surgery28. Short-stay (≤ 1 d) diverting loop ileostomy closure can be selectively implemented without an increase in readmission and complication rates: an ACS-NSQIP analysis29. A comparison of perineal stapled rectal prolapse resection and the Altemeier procedure at 2 Canadian academic hospitals30. Mental health and substance use disorders predict 90-day readmission and postoperative complications following rectal cancer surgery31. Early discharge after colorectal cancer resection: trends and impact on patient outcomes32. 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Autor: M. Connell, W. Lin, A. Jarrar, A. Mierzwa, J. Shiroky, Z. Cloutier, F. Deaninck, W. He, Y. Lee, S. Keshavjee, M. Fortin, C. McLean, M. Melland-Smith, J. Frigault, G. Chartrand, N. Zuker, S. Elbekri, Z. Mir, R. Gilbert, V. Smith, H. Shrader, Y. Essaji, A. Webb, J. Glinka, E. Waugh, L. Park, M. Lund, M. Lemke, D. Henault, J. Zuckerman, N. Hanna, F. Reyna-Sepulveda, T. Lenet, K. Verhoeff, M. Parapini, D. Lim, S. Langer, D. Nguyen, C. Mardinger, A. Allard-Coutu, D. Cyr, K. Allen, D. Ng, L. Cadili, H. Kapur, S. Mysuria, É. Di Lena, V. Pravong, A. Alqaydi, A. Hunter-Smith, N. Gagnon, A. DiPasquale, W. Marini, M. Jacobson, V. Li, S. Merchant, A. Azin, R. Szwimer, N. Kasteel, E. Papillon, N. Alghaithi, M. Hegagi, Z. Harra, V. Wiseman, E. Salama, J. Moon, H. Roy, J. Liang, Z. Bayat, N. Caminsky, M.K. Motamedi, R. Ruxton, O. AlAamer, O. Monton, M. Li, C. Brown, J. Holland, R. Selvam, V. Brissette, T. McKechnie, H. AlSulaim, G. Talwar, R. Garfinkle, K. Purich, R. Hajjar, C. Cahill, G. Johnson, A. Bruinooge, K. Graham, H. Wang, M. Robinson, V. Gupta, E. Peters, L. Qu, D. Jones, C. Finley, I. Churchill, N. Hunka, M. Kaafarani, Y. Patel, D. Le Nguyen, S. Abdul, M. Humer, D. Sisson, A. Al Rawahi, C. Huynh, B. Greenberg, Y. Shargall, S. Turner, A. Alghamedi, V. Resende, S. Brophy, L. Esther, A. Kammili, M. De Meo, R. Razzak, N. Mistry, R. Nayak, D. Hirpara, J. Alaichi, A. Ednie, M. Abbas, U. Jogiat, K. Sullivan, G. Akhtar-Danesh, R. He, L. Lan, K. Larsen, M. Abou Khalil, K. Guidolin, G. Pang, J. Drung, C. Li, H. Wilson, N. Patro, E. Schmitz, W. Sun, R. Liu, C. Dwyer, R. Raskin, R. Wigen, K. Singh, G. Skelhorne-Gross, A. Rosenzveig, H. Muaddi, K. Ren, A. Lee, E. Walser, H. Forbes, C. Kruse, P.E. Serrano Aybar, U. Do, D. Skubleny, A. Fecso, A. Miles, S. Balvardi, L. Lee, L. Kerr, L. Glass, K. D’Souza, M. Nguyen, A. Zhu, K. Nabata, E. Ertel, R. Guo, J. Gentles, F. Shariff, K. Hickey, A. Vergis, B. Unger, J. Park, L. Gillman, D. Pace, K. Lam-Tin-Cheung, S. Chadi, F. Quereshy, J. Catton, B. Rubin, J. Bell, J. Marangos, A. Heesters, T. Stuart-McEwan, F. Wright, N. Ahmed, A. Nadler, J. Hallet, L. Chen, H. Hwang, R. Sidhu, T. Scott, A. Karimuddin, A. Nguyen, J. Osborn, S. Wiseman, L. Baker, M. Vered, A. Zahrai, R. Shorr, A. Davis, D. McIsaac, A. Tinmouth, D. Fergusson, G. Martel, S. Rummel, M. Stefic-Cubic, M. Stewart, A. Melck, T. Anpalagan, S. Ichhpuniani, K. Ramji, C. Eskicioglu, S. Deng, B. Greene, M. Tsang, V. Palter, S. Jayaraman, A. Mann, J. Tittley, M. Cadeddu, A. Madani, J. Pasternak, D. Hong, A. Istl, E. Tang, D. Gray, N. Coburn, J. Callum, R. McLeod, E. Pearsall, Y. Lin, A. Turgeon, A. Mahar, P. Kriviraltcheva-Kaneva, J. Cools-Lartigue, L. Ferri, C. Mueller, B. Haas, B. Tillman, M. Guttman, T. Chesney, V. Zuk, A. Hsu, W. Chan, R. Vasdev, L. Cadili J. Ling, R. Warburton, M. Hameed, H. Williamson, P. Murphy, K. Leslie, J. Hawel, S. Zablotny, H. Roldan, X. Jiang, B. Zheng, J. Fiore, L. Feldman, G. Fried, S. Valanci, J. Cipolla, P. Kaneva, S. Demyttenaere, M. Boutros, M. Alhashemi, J. Shapiro, D. Bigam, J. Kung, J. Mosko, P. Hamilton, S. Ghosh, S. Widder, D. Schiller, C. El Kefraoui, M. Pook, N. Barone, H. Montgomery, P. Nguyen-Powanda, F. Rajabiyazdi, H. Elhaj, M. Lapointe-Gagner, G. Olleik, A. Antoun, N. Safa, E. Di Lena, S. Meterissian, A. Meguerditchian, F. Lee, G. Baldini, S. Parpia, L. Ruo, K. Tywonek, S. Lee, C. O’Neill, N. Faisal, A. Alfayyadh, M. Gundayao, B.M. Meyers, R. Habashi, M. Levin, K. Aldrich, T. Grantcharov, A. Langerman, R. Anantha, V. Fawcett, A. Hetherington, M. Gervais, G. Rakovich, R. Hu, R. Musselman, I. Raiche, H. Moloo, A. Elnahas, N. Alkhamesi, A. Alnumay, C. Schlachta, C. Zhang, S. Cristancho, M. Ott, B. Niu, F. Balaa, N. Gawad, Y. Qiu, K. Hamann, N. How, C. Leveille, A. Davidson, A. Eqbal, Y. Sardiwalla, M. Korostensky, E. Lee, I. Yang, T. Stukel, C. de Mestral, A. Nathens, P. Karanicolas, S. Lemieux, D. Breton, P. Bouchard, A. Bouchard, R. Grégoire, F. Letarte, G. Bouchard, S. Drolet, S. 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Scudamore, M. Segedi, E. Vasilyeva, J. Li, P. Kim, A. Deprato, K. Dajani, R. Smoot, C. Tzeng, F. Rocha, L. Yohanathan, S. Cleary, K. Bertens, D. Badrudin, B. Gala-Lopez, X. Wei, Y. Kaliwal, A. Wei, B. Barrette, S. Pelletier, P. Thebault, E. Beaudry-Simoneau, Z. Rong, M. Plasse, A. Roy M. Dagenais, R. Létourneau, R. Lapointe, F. Vandenbroucke-Menu, B. Nguyen, G. Soucy, S. Turcotte, D. Quan, A. Skaro, G. Jada, J. Daza, H. Msallak, B. Zhang, A. Workneh, S. Faisal, R. Faisal, M. Fabbro, C. Gu, M. Claassen, G. Sapisochin, D. Breadner, S. Welch, E. Lester, A. Shapiro, D. Eurich, A. Nayyar, M. Suraju, S. Williams-Perez, P. Ear, C. Chan, M. Rivers-Bowerman, A. Costa, A. Stueck, N. Campbell, S. Allen, H. Golding, S. McKeown, J. Flemming, P. Groome, M. Djerboua, E. Girard, P. Morency-Potvin, M. Dagenais, A. Roy, R. Letourneau, E. Simoneau, M. Oakley, B. Misheva, Y. Bendavid, L. Smith, J. Tan, U. Kahn, X. Paré, A. Doyon, K. Schwenger, J. Yadav, S. Fischer, T. Jackson, J. Allard, A. Okrainec, S. Anvari, O. Lovrics, I. Aditya, A. Khondker, M. Walsh, K. Hardy, R. Romanescu, J. Linton, M. Fowler-Woods, A. Fowler-Woods, G. Shingoose, M. Zmudzinski, V. Archer, J. Abu Halimah, V. Boudreau, G. Marcil, A. Hardy-Henry, J. Hagen

Publikováno v: Canadian Journal of Surgery. 64:S80-S159

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eca3206107f330dbb544b0cecb24e9ab
https://doi.org/10.1503/cjs.021321

Microfluidic Chamber Design for Controlled Droplet Expansion and Coalescence

Autor: Mark Kielpinski, Oliver Walther, Jialan Cao, Thomas Henkel, J. Michael Köhler, G. Alexander Groß

Publikováno v: Micromachines, Vol 11, Iss 4, p 394 (2020)

The defined formation and expansion of droplets are essential operations for droplet-based screening assays. The volumetric expansion of droplets causes a dilution of the ingredients. Dilution is required for the generation of concentration graduatio

Externí odkaz: https://doaj.org/article/5d2ca4729c9142f082bad9448d173393

Checkpoint Inhibitors in Relapsed/Refractory Classical Hodgkin Lymphoma

Autor: Kidist Tarekegn, Ana Colon Ramos, Harry G Sequeira Gross, Sachin Gupta, Balraj Singh

Publikováno v: World Journal of Oncology

Even though classical Hodgkin lymphoma is highly curable, the outcome of patients with a refractory or relapsed disease has been disappointing. Multiple lines of therapy are available for patients after their first failure, and most respond to subseq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6d8de5c8376c291e5b8795adbba233
https://doi.org/10.14740/wjon1388