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Preparation of Adhesion Culture of Neural Stem/Progenitor Cells of the Olfactory Mucosa for the Treatment of Spinal Cord Injuries

Autor: Igor V. Reshetov, M P Valikhov, D A Vishnevskii, E. K. Karsuntseva, A D Voronova, O. V. Stepanova, G. A. Fursa, A. V. Chadin, Vladimir P. Chekhonin

Publikováno v: Bulletin of Experimental Biology and Medicine. 170:158-163

In this work, an optimal protocol was developed for obtaining adhesion culture of neural stem/progenitor cells (NSPC) of rat olfactory mucosa. During the development of the protocol, the conditions for cell culturing on adhesion substrates fibronecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11a49bc8a21a0c954597168c724608f
https://doi.org/10.1007/s10517-020-05023-0

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Combined Preparation of Human Olfactory Ensheathing Cells in the Therapy of Post-Traumatic Cysts of the Spinal Cord

Autor: A. S. Semkina, E. K. Karsuntseva, G. A. Fursa, M P Valikhov, A. V. Chadin, A D Voronova, Vladimir P. Chekhonin, Igor V. Reshetov, O. V. Stepanova

Publikováno v: Bulletin of Experimental Biology and Medicine. 169:539-543

In experiments on rats, co-transplantation of olfactory ensheathing cells of the human olfactory mucosa and neural stem/progenitor cells from the same source into post-traumatic cysts of the spinal cord led to improvement of the motor activity of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dac378ef6a0ee6636e6c712dcf3cf5
https://doi.org/10.1007/s10517-020-04925-3

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Obtaining a New Gene-Cell Construct Based on Transduced Olfactory Ensheathing Cells for the Treatment of Spinal Cord Injuries

Autor: A D, Voronova, A O, Sosnovtseva, O V, Stepanova, A V, Chadin, E K, Karsuntseva, G A, Fursa, I V, Reshetov, V P, Chekhonin

Publikováno v: Bulletin of experimental biology and medicine. 173(4)

We developed a viral vector Ad5/35-CAG-mBDNF expressing the mature form of BDNF (mBDNF). On the basis of olfactory ensheathing cells transduced with this adenovector, a new gene-cell construct was obtained. In experiments in vitro, high viability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38fa755bb35d7df81c906c581fb9d69e
https://pubmed.ncbi.nlm.nih.gov/36058977

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Application of a New Gene-Cell Construct Based on the Olfactory Mucosa Escheating Cells Transduced with an Adenoviral Vector Encoding Mature BDNF in the Therapy of Spinal Cord Cysts

Autor: E K, Karsuntseva, G A, Fursa, A O, Sosnovtseva, A D, Voronova, A V, Chadin, A S, Semkina, O V, Stepanova, V P, Chekhonin

Publikováno v: Bulletin of experimental biology and medicine. 172(5)

A gene-cell construct based on rat olfactory mucosa ensheathing cells transduced with an adenoviral vector encoding a mature form of brain neurotrophic factor (mBDNF) was transplanted into post-traumatic cysts of rat spinal cord. Transplantation of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bdb9ab632cf3fb51d80830c7822640b
https://pubmed.ncbi.nlm.nih.gov/35352253

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Neurotrophin-3 Enhances the Effectiveness of Cell Therapy in Chronic Spinal Cord Injuries

Autor: O V, Stepanova, A D, Voronova, A V, Chadin, G A, Fursa, E K, Karsuntseva, M P, Valikhov, A S, Semkina, I V, Reshetov, V P, Chekhonin

Publikováno v: Bulletin of experimental biology and medicine. 173(1)

Neurotrophin-3 enhances the effectiveness of human olfactory ensheathing cells in improving hind limb mobility in rats with post-traumatic cysts of the spinal cord. Transplantation of olfactory ensheathing cells into spinal cord cysts reduced their s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02808be9268314231e2eaf8a6b37828c
https://pubmed.ncbi.nlm.nih.gov/35622252

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OBTAINING OF CELLULAR PREPARATIONS OF RAT AND HUMAN OLFACTORY MUCOSA AND THEIR INFLUENCE ON THE SIZE OF MODELED SPINAL CORD CYSTALS

Autor: Vladimir P. Chekhonin, A. V. Chadin, E. K. Karsuntseva, O. V. Stepanova, Igor V. Reshetov, G. A. Fursa, M P Valikhov, A.P Semkina

Publikováno v: http://eng.biomos.ru/conference/articles.htm. 1:75-77

Enriched cultures of olfactory ensheathing cells and neural stem/progenitor cells were obtained according to our developed protocols from the olfactory mucosa of rat and human. It has been shown that only transplantation of human and rat olfactory en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6c4347850f53623ec3f0482c441c022
https://doi.org/10.37747/2312-640x-2021-19-75-77

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