Zobrazeno 1 - 10
of 36
pro vyhledávání: '"G. A. Finlay"'
Publikováno v:
Journal of Hospital Medicine. 9:116-119
Early detection of an impending cardiac or pulmonary arrest is an important focus for hospitals trying to improve quality of care. Unfortunately, all current early warning systems suffer from high false-alarm rates. Most systems are based on the Modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76110093b6ab03e4523192ecf4271817
https://doi.org/10.1002/jhm.2132
https://doi.org/10.1002/jhm.2132
Publikováno v:
BMJ Open
Objectives: This study investigates risk of mortality associated with nurses’ assessments of patients by physiological system. We hypothesise that nursing assessments of in-patients performed at entry correlate with in-hospital mortality, and those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5c3095d82d52ff9c2b94e621ba1b35
https://pubmed.ncbi.nlm.nih.gov/22874626
https://pubmed.ncbi.nlm.nih.gov/22874626
Publikováno v:
Infectious Diseases in Clinical Practice. 8:218-220
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::390c5788a532b301750301cc35c9cf6d
https://doi.org/10.1097/00019048-199905000-00016
https://doi.org/10.1097/00019048-199905000-00016
Publikováno v:
Anti-cancer drug design. 16(6)
DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide dihydrochloride) has high experimental antitumor activity and has completed phase I/II clinical trials. It targets both topoisomerase (topo) I and II, but the roles of each of these enzymes in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a83dd7599c9833c94ddd73ae1bd04e39
https://pubmed.ncbi.nlm.nih.gov/12375884
https://pubmed.ncbi.nlm.nih.gov/12375884
Publikováno v:
Oncology research. 11(6)
The action of the anticancer drug amsacrine appears to involve molecular interactions with both DNA and topoisomerase II. It has been shown previously that DNA intercalators can inhibit the action of amsacrine and several other topoisomerase II poiso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::927f13a9c0020e05e14a2476cf5d3ed2
https://pubmed.ncbi.nlm.nih.gov/10691026
https://pubmed.ncbi.nlm.nih.gov/10691026
Publikováno v:
Oncology research. 11(3)
The culture of surgical tumor specimens has long been considered as a potential approach to the tailoring of chemotherapy and radiotherapy to the individual patient, and to the development of improved therapy. Recent work highlighting the importance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b749277d656b8c334e3366cd18e408d
https://pubmed.ncbi.nlm.nih.gov/10527071
https://pubmed.ncbi.nlm.nih.gov/10527071
Publikováno v:
Anti-cancer drug design. 14(3)
A series of tricyclic aromatic carboxamides, and their corresponding dimeric analogues, were prepared and their growth-inhibitory properties were evaluated in a series of cell lines. The dimeric compounds were prepared by reaction of the appropriate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::174ac09f86e7d3da9cf3c13b7333bb86
https://pubmed.ncbi.nlm.nih.gov/10500503
https://pubmed.ncbi.nlm.nih.gov/10500503
Publikováno v:
Anti-cancer drug design. 14(3)
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA), a DNA intercalating dual topoisomerase I/II poison, has high experimental antitumour activity, is able to overcome several forms of multidrug resistance, and is undergoing clinical trial. We pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afec78e5ed6c5b437f25631523f02e8d
https://pubmed.ncbi.nlm.nih.gov/10500502
https://pubmed.ncbi.nlm.nih.gov/10500502
Publikováno v:
Anti-cancer drug design. 14(1)
DACA is a DNA-intercalating agent and dual topoisomerase (topo) I/II inhibitor currently in clinical trial as an anticancer drug. Substitutions in the acridine ring of DACA have significant effects on biological activity, with 5-substituted analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54b7c42114b81a3f0cd8f2e1d46a156e
https://pubmed.ncbi.nlm.nih.gov/10363026
https://pubmed.ncbi.nlm.nih.gov/10363026
Autor:
R. Coakley, S. O’Neill, P. Glynn, G. A. Finlay, K. J. Russell, K. McMahon, E. M. D’Arcy, J. B. Masterson, M. X. Fitzgerald, C. M. O’Connor, L. R. O’Driscoll, L. P. A. McGarvey, P. Forsythe, L. G. Heaney, J. MacMahon, M. Ennis, C. Leonard, V. Tormey, C. M. Burke, L. W. Poulter, V. M. Keatings, M. X. FitzGerald, P. J. Barnes, H. R. Harty, D. R. Corfield, L. Adams, R. M. Schwartzstein, J. F. Kiely, A. Buckley, P. Shiels, P. C. Deegan, B. Maurer, W. T. McNicholas, K. A. Dunlop, B. Martin, M. Riley, M. D. Shields, I. Kilgallen, N. G. McElvaney, D. Cervantes-Laurean, N. Wehr, K. Gabriele, W. Robinson, J. Moss, R. L. Levine, V. Urbach, D. Walsh, B. Harvey, M. C. McElroy, J-F. Pittet, L. Allen, J. Wiener-Kroonish, L. G. Dobbs, D. M. O’Donnell, K. J. McMahon, C. O’Connor, P. McGuirk, B. Mahon, F. Griffin, K. H. G. Mills, R. Murphy, F. Brijker, E. Mulloy, J. W. Cohen Tervaert, J. Walshe, R. C. Lowry, D. R. T. Shepherd, L. A. Gamble, C. Carton, R. Memon, D. Winter, A. Chan, T. Aherne, P. O’Reilly, J. A. Harbison, S. O’Callaghan, M. Keane, M. McKenna, S. Woods, A. Lamon, J. Faul, M. Murphy, J. Porszasz, M. P. K. J. Engelen, B. Brundage, K. Wasserman, M. Sweeney, R. G. O’Regan, P. McLoughlin, V. Honner, B. Sinnott, D. S. McGrath, J. Kiely, B. Cryan, C. P. Bredin, C. Shortt, M. Stack, N. Kelleher, J. McRedmond, N. Mulkerji, V. Keatings, G. M. Boylan, L. J. M. Cross, S. Davern, T. J. McDonnell, J. L. Kiely, G. Lawless, S. Cunningham, J. Lordan, L. Clancy, P. Manning, P. Plunkett, D. Donaghy, F. Ben Musbah, B. G. Loftus, R. Rutherford, S. N. E. Watson, J. J. Gilmartin, M. Henry, G. Mullins, N. Brennan
The abstract is included in the text.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc321965a7121bb561b8ec84b96bc45
http://mural.maynoothuniversity.ie/12458/
http://mural.maynoothuniversity.ie/12458/
