Zobrazeno 1 - 10 of 53 pro vyhledávání: '"G. Kenneth Lloyd"'
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Akademický článek
Plinabulin, a Distinct Microtubule-Targeting Chemotherapy, Promotes M1-Like Macrophage Polarization and Anti-tumor Immunity
Autor: Marina Natoli, Petra Herzig, Elham Pishali Bejestani, Melanie Buchi, Reto Ritschard, G. Kenneth Lloyd, Ramon Mohanlal, James R. Tonra, Lan Huang, Viola Heinzelmann, Marta Trüb, Alfred Zippelius, Abhishek S. Kashyap
Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Reprogramming tumor infiltrating myeloid cells to elicit pro-inflammatory responses is an exciting therapeutic maneouver to improve anti-tumor responses. We recently demonstrated that a distinct microtubule-targeting drug, plinabulin—a clinical-sta
Externí odkaz: https://doaj.org/article/d21b4ca37c104d1593f619178ef9f5c2
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Plinabulin ameliorates neutropenia induced by multiple chemotherapies through a mechanism distinct from G-CSF therapies
Autor: Ramon Mohanlal, James R. Tonra, Lan Huang, G. Kenneth Lloyd
Publikováno v: Cancer Chemotherapy and Pharmacology
Purpose Chemotherapy-induced neutropenia (CIN) increases the risk of infections and mortality in cancer patients. G-CSF therapies are approved for the treatment of CIN, but non-G-CSF therapies are needed to increase efficacy and minimize side effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbfe03aa14e4852c541639a6a0bb4fe
https://doi.org/10.1007/s00280-019-03998-w
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Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling
Autor: Lihua Du, Yanping Wu, Jessica Dalsing-Hernandez, Mary Ann Jordan, Leslie Wilson, Steffan T. Nawrocki, Kari Kotlarczyk, Jamie Bishop, Lan Huang, Paul Gonzales, Hans-Georg Wirsching, Patrick J. Cimino, G. Kenneth Lloyd, Jennifer S. Carew
Publikováno v: Biomedical Reports
Constitutive activation of Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most common oncogenic event in certain types of human cancer and is associated with poor patient survival. Small molecule signaling inhibitors have improved the clini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1f4f2c6a3d41c3906e2899c52aa8f7
https://www.zora.uzh.ch/id/eprint/176137/
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Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes
Autor: Michel O. Steinmetz, G. Kenneth Lloyd, Francisco de Asis Balaguer Perez, Lan Huang, Giuseppina La Sala, Andrea Cavalli, Natacha Olieric, Federica Viti, José Fernando Díaz, Ashwani Sharma, Sergio Decherchi, James R. Tonra
Publikováno v: Chem (Cambridge. Print) 5 (2019): 2969–2986. doi:10.1016/j.chempr.2019.08.022
info:cnr-pdr/source/autori:La Sala G.; Olieric N.; Sharma A.; Viti F.; de Asis Balaguer Perez F.; Huang L.; Tonra J.R.; Lloyd G.K.; Decherchi S.; Diaz J.F.; Steinmetz M.O.; Cavalli A./titolo:Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes/doi:10.1016%2Fj.chempr.2019.08.022/rivista:Chem (Cambridge. Print)/anno:2019/pagina_da:2969/pagina_a:2986/intervallo_pagine:2969–2986/volume:5
Digital.CSIC. Repositorio Institucional del CSIC
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25 p.-5 fig.-1 tab. + 6 fig. supl.+ 1 tab. supl.
αβ-Tubulin is a validated target for anticancer drug discovery, and molecules binding to this protein are used to treat several types of tumors. Here, we report on a combined X-ray crystallograp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b99b1daca5dd2565c568532d8c33feb
http://www.cnr.it/prodotto/i/449379
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Abstract 5030: Microtubule destabilization by plinabulin generates anti-tumor immune response through repolarization of intratumoral macrophages
Autor: Alfred Zippelius, James R. Tonra, Melanie Buchi, G. Kenneth Lloyd, Lan Huang, Abhishek S. Kashyap, Petra Herzig, Reto Ritschard, Elham Pishali Bejestani, Ramon Mohanlal
Publikováno v: Cancer Research. 79:5030-5030
The M2 phenotype is dominant in tumor associated macrophages (TAMs) and correlates with poor prognosis. As M1 polarized macrophages possess anti-tumor functions, in vivo reprogramming of macrophages is a promising strategy for cancer treatment. We re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::571b1e764903c848ffc907b228c6999d
https://doi.org/10.1158/1538-7445.am2019-5030
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Abstract 1254: Predictive models for tumor cell targeting with plinabulin, derived from in vitro screening and Affymetrix mRNA expression data
Autor: James R. Tonra, Hagen Klett, Chenghao Shen, Gerhard Kelter, Ramon W. Mohanlal, G. Kenneth Lloyd, Lan Huang
Publikováno v: Cancer Research. 79:1254-1254
Tubulin binding drugs are approved for the treatment of many cancer types, without the use of molecular markers to select patients likely to respond. Plinabulin binds β-tubulin in a differentiated pocket and is being tested in a Phase 3 clinical stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16e946353bd027040ac478c628e323e5
https://doi.org/10.1158/1538-7445.am2019-1254
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Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier
Autor: Kaijun Di, Vivek Abraham, Ann MacLaren, Daniela A. Bota, Francis Burrows, Mohit Trikha, Annick Desjardins, G. Kenneth Lloyd
Publikováno v: Di, K; Lloyd, GK; Abraham, V; MacLaren, A; Burrows, FJ; Desjardins, A; et al.(2016). Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier. NEURO-ONCOLOGY, 18(6), 840-848. doi: 10.1093/neuonc/nov299. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3td7095n
Neuro-oncology, vol 18, iss 6
Author(s): Di, Kaijun; Lloyd, G Kenneth; Abraham, Vivek; MacLaren, Ann; Burrows, Francis J; Desjardins, Annick; Trikha, Mohit; Bota, Daniela A | Abstract: BackgroundThe proteasome plays a vital role in the physiology of glioblastoma (GBM), and protea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189cad27274943aad25e5e0de0d7bc38
http://www.escholarship.org/uc/item/3td7095n
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9
Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin(NPI-2358) in Patients with Solid Tumors or Lymphomas
Autor: Lisa Malburg, Alain C. Mita, G. Kenneth Lloyd, Lorrin K. Yee, Kristine C. Federico, Ofelia Romero, Matthew A. Spear, Elisabeth I. Heath, Gillian Cropp, Steven Reich, Patricia LoRusso, M. J. Pilat, Kyriakos P. Papadopoulos, Monica M. Mita, Saskia T. C. Neuteboom, Edward Ashton
Publikováno v: Clinical Cancer Research. 16:5892-5899
Purpose: Plinabulin (NPI-2358) is a vascular disrupting agent that elicits tumor vascular endothelial architectural destabilization leading to selective collapse of established tumor vasculature. Preclinical data indicated plinabulin has favorable sa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711bb300c3d919531c1c45ce864f9150
https://doi.org/10.1158/1078-0432.ccr-10-1096
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Development of pharmacotherapies for drug addiction: a Rosetta Stone approach
Autor: George F. Koob, Barbara J. Mason, G. Kenneth Lloyd
Publikováno v: Nature Reviews Drug Discovery. 8:500-515
Current pharmacotherapies for addiction represent opportunities for facilitating treatment and are forming a foundation for evaluating new medications. Furthermore, validated animal models of addiction and a surge in understanding of neurocircuitry a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee1e8f1061e2eb81626bf6beadcfed5
https://doi.org/10.1038/nrd2828
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