Výsledky vyhledávání

Akademický článek

Multivariable Mendelian randomization with incomplete measurements on the exposure variables in the Hispanic Community Health Study/Study of Latinos

Autor: Yilun Li, Kin Yau Wong, Annie Green Howard, Penny Gordon-Larsen, Heather M. Highland, Mariaelisa Graff, Kari E. North, Carolina G. Downie, Christy L. Avery, Bing Yu, Kristin L. Young, Victoria L. Buchanan, Robert Kaplan, Lifang Hou, Brian Thomas Joyce, Qibin Qi, Tamar Sofer, Jee-Young Moon, Dan-Yu Lin

Publikováno v: HGG Advances, Vol 5, Iss 4, Pp 100338- (2024)

Summary: Multivariable Mendelian randomization allows simultaneous estimation of direct causal effects of multiple exposure variables on an outcome. When the exposure variables of interest are quantitative omic features, obtaining complete data can b

Externí odkaz: https://doaj.org/article/5171015866ab400cb3f6deffca141767

Zobrazit plný text záznamu

Akademický článek

Branched chain amino acids harbor distinct and often opposing effects on health and disease

Autor: Christy L. Avery, Annie Green Howard, Harold H. Lee, Carolina G. Downie, Moa P. Lee, Sarah H. Koenigsberg, Anna F. Ballou, Michael H. Preuss, Laura M. Raffield, Rina A. Yarosh, Kari E. North, Penny Gordon-Larsen, Mariaelisa Graff

Publikováno v: Communications Medicine, Vol 3, Iss 1, Pp 1-8 (2023)

Abstract Background The branched chain amino acids (BCAA) leucine, isoleucine, and valine are essential nutrients that have been associated with diabetes, cancers, and cardiovascular diseases. Observational studies suggest that BCAAs exert homogeneou

Externí odkaz: https://doaj.org/article/33a3c57423f141d8b3603098fa178114

Zobrazit plný text záznamu

Akademický článek

Mendelian randomization with incomplete measurements on the exposure in the Hispanic Community Health Study/Study of Latinos

Publikováno v: HGG Advances, Vol 5, Iss 1, Pp 100245- (2024)

Summary: Mendelian randomization has been widely used to assess the causal effect of a heritable exposure variable on an outcome of interest, using genetic variants as instrumental variables. In practice, data on the exposure variable can be incomple

Externí odkaz: https://doaj.org/article/cbe905cc5ce0437cbe3b05f57e464168

Zobrazit plný text záznamu

Akademický článek

Ancestral diversity in lipoprotein(a) studies helps address evidence gaps

Publikováno v: Open Heart, Vol 10, Iss 2 (2023)

Introduction The independent and causal cardiovascular disease risk factor lipoprotein(a) (Lp(a)) is elevated in >1.5 billion individuals worldwide, but studies have prioritised European populations.Methods Here, we examined how ancestrally diverse s

Externí odkaz: https://doaj.org/article/1a269fc98b7043cc85c2bdef81e77451

Zobrazit plný text záznamu

Abstract P197: HbA1c Partially Mediates the Effect of Tyrosine and Phenylalanine on Incident Myocardial Infarction

Autor: Sarah H Koenigsberg, Mariaelisa Graff, Anna F Ballou, Carolina G Downie, Annie Green Howard, Moa P Lee, Kari E North, Laura M Raffield, Rina Yarosh, Penny Gordon-Larsen, Christy L Avery

Publikováno v: Circulation. 147

Introduction: The aromatic amino acids tyrosine and phenylalanine may increase type 2 diabetes risk, but few studies have examined whether these critical molecular precursors exert additional phenotypic effects and whether these effects are independe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4568251f122ec377b3f1be817ab73e43
https://doi.org/10.1161/circ.147.suppl_1.p197

Zobrazit plný text záznamu

Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods

Autor: Christy L. Avery, Annie Green Howard, Anna F. Ballou, Victoria L. Buchanan, Jason M. Collins, Carolina G. Downie, Stephanie M. Engel, Mariaelisa Graff, Heather M. Highland, Moa P. Lee, Adam G. Lilly, Kun Lu, Julia E. Rager, Brooke S. Staley, Kari E. North, Penny Gordon-Larsen

Publikováno v: Environmental Health Perspectives. 130

Advances in technologies to measure a broad set of exposures have led to a range of exposome research efforts. Yet, these efforts have insufficiently integrated methods that incorporate genetic data to strengthen causal inference, despite evidence th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31019186bc6dfd54df59e5bad2ef6951
https://doi.org/10.1289/ehp9098

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání