Zobrazeno 1 - 10
of 16
pro vyhledávání: '"G. A. Sega"'
Publikováno v:
Clinical and experimental dermatology. 41(1)
We describe a case of cutaneous diphtheria in the UK, presenting as lower leg ulcers in a returning traveller, and discuss the epidemiology, significance and public health implications of this disease and the therapeutic options available. A 65-year-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac86aba160055e7fc88e62e0ab70a5cc
https://pubmed.ncbi.nlm.nih.gov/26455435
https://pubmed.ncbi.nlm.nih.gov/26455435
Publikováno v:
Environmental and Molecular Mutagenesis. 16:64-69
Diesel exhaust (DE) is a pulmonary carcinogen in rats. One potential mechanism for DE-induced carcinogenicity involves the interaction of the organic chemicals associated with DE soot with DNA in target cells. The purpose of this study was to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39b13c6286bb6ecf5f89f20c22ca598
https://doi.org/10.1002/em.2850160203
https://doi.org/10.1002/em.2850160203
Autor:
P. L. Piotrowski, B. G. Sumpter, H. V. Malling, J. S. Wassom, P. Y. Lu, R. A. Brothers, G. A. Sega, S. A. Martin, M. Parang
Publikováno v:
ChemInform. 38
A computational approach has been developed for performing efficient and reasonably accurate toxicity evaluation and prediction. The approach is based on computational neural networks linked to modern computational chemistry and wavelet methods. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8457683af7e5ddb7c59ca5dbf224925
https://doi.org/10.1002/chin.200725205
https://doi.org/10.1002/chin.200725205
Autor:
R E, Sotomayor, G A, Sega
Publikováno v:
Environmental and molecular mutagenesis. 36(4)
The unscheduled DNA synthesis (UDS) assay measures DNA repair in response to DNA damage. To date, 59 chemicals plus UV and X rays have been tested for UDS in spermatogenic cells of humans, rabbits, rats, and mice. In vivo, in vitro, and combined in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::875efeb2ed972ab011a2df6ad9e2cf2f
https://pubmed.ncbi.nlm.nih.gov/11152558
https://pubmed.ncbi.nlm.nih.gov/11152558
Publikováno v:
Teratogenesis, carcinogenesis, and mutagenesis. 19(5)
An autoradiographic procedure was used to measure unscheduled DNA synthesis (UDS, DNA repair synthesis) in spermatogonial and postspermatogonial cell stages of mice after treatment with two doses of N-ethyl-N-nitrosourea (ENU) and N-methyl-N-nitrosou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6212bfc015be9133be20dc29f9812be1
https://pubmed.ncbi.nlm.nih.gov/10495451
https://pubmed.ncbi.nlm.nih.gov/10495451
Autor:
Katherine T. Cain, Lr Hughes, N.L.A. Cacheiro, Walderico M. Generoso, Michael D. Shelby, A.M. Lockhart, G. A. Sega
Publikováno v:
Mutation research. 371(3-4)
The hypothesis that acrylamide induces dominant lethal mutations and heritable translocations in male mice, not through direct adduction, but by conversion to the reactive epoxide, glycidamide, was investigated. Three studies, namely, induction of do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d9c750023fb21fe04beb796cfdec86
https://pubmed.ncbi.nlm.nih.gov/9008719
https://pubmed.ncbi.nlm.nih.gov/9008719
Autor:
G A, Sega
Publikováno v:
Progress in clinical and biological research. 372
In mammals, variability in the genetic sensitivity of different germ-cell stages to mutagens could be the result of how much chemical reaches the different stages, what molecular targets may be affected in the different stages and whether or not repa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::390334c51a86f9067e1a8f5090e776e5
https://pubmed.ncbi.nlm.nih.gov/1956945
https://pubmed.ncbi.nlm.nih.gov/1956945
Autor:
G A, Sega
Publikováno v:
Progress in clinical and biological research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52557fa06a198803dd266d7e72816713
https://pubmed.ncbi.nlm.nih.gov/2381922
https://pubmed.ncbi.nlm.nih.gov/2381922
Autor:
P. L. Piotrowski, B. G. Sumpter, H. V. Malling, J. S. Wassom, P. Y. Lu, R. A. Brothers, G. A. Sega, S. A. Martin, M. Parang
Publikováno v:
Journal of Chemical Information & Modeling; Mar2007, Vol. 47 Issue 2, p676-685, 10p
Autor:
L.A. Hughes, Walderico M. Generoso, G. A. Sega, Katherine T. Cain, D. G. Gosslee, M.D. Shelby, P.W. Braden
Publikováno v:
Environmental Mutagenesis. 8:1-7
In the dose-response study, male mice were exposed by inhalation to ethylene oxide (EtO) for 4 consecutive days. Mice were exposed for 6 hr per day to 300 ppm, 400 ppm, or 500 ppm EtO for a daily total of 1,800, 2,400, or 3,000 ppm X hr (total exposu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a9b0c27757fa5ec0537b4812a064af
https://doi.org/10.1002/em.2860080102
https://doi.org/10.1002/em.2860080102