High throughput screening of a new fluorescent G-quadruplex ligand having telomerase inhibitory activity in human A549 cells.

Autor: Ghosh, Sourav¹ (AUTHOR), De, Debapriya¹ (AUTHOR), Banerjee, Victor¹ (AUTHOR), Biswas, Soumyajit¹ (AUTHOR), Ghosh, Utpal¹ (AUTHOR)

Publikováno v: Nucleosides, Nucleotides & Nucleic Acids. 2023, Vol. 42 Issue 9, p696-717. 22p.

Modeling and NMR Data Elucidate the Structure of a G-Quadruplex-Ligand Interaction for a Pu22T-Cyclometalated Iridium(III) System.

Autor: Reed CR; Department of Chemistry and Biochemistry, SUNY Brockport, Brockport, New York 14420, United States., Kennedy SD; Department of Biochemistry & Biophysics and Center for RNA Biology, University of Rochester Medical Center, Rochester, New York 14642, United States., Horowitz RH; Department of Chemistry and Biochemistry, SUNY Brockport, Brockport, New York 14420, United States., Keedakkatt Puthenpeedikakkal AM; Department of Biochemistry & Biophysics and Center for RNA Biology, University of Rochester Medical Center, Rochester, New York 14642, United States., Stern HA; Orogen Therapeutics, 12 Gill Street Suite 4200, Woburn, Massachusetts 01801, United States., Mathews DH; Department of Biochemistry & Biophysics and Center for RNA Biology, University of Rochester Medical Center, Rochester, New York 14642, United States.

Publikováno v: The journal of physical chemistry. B [J Phys Chem B] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.

Structural Perspective into the Interaction of an Oncogenesis‐Relevant pre‐miRNA G‐Quadruplex Ligand Carrier with the Protein Nucleolin.

Autor: Santos, Tiago¹ (AUTHOR), Silva, Micael¹ (AUTHOR), Imbert, Lionel^2,3 (AUTHOR), Campello, Maria P. C.⁴ (AUTHOR), Paulo, António⁴ (AUTHOR), Amrane, Samir⁵ (AUTHOR), Salgado, Gilmar F.⁵ (AUTHOR), Cruz, Carla^1,6 (AUTHOR) carlacruz@fcsaude.ubi.pt, Cabrita, Eurico J.^7,8 (AUTHOR) ejc@fct.unl.pt

Publikováno v: Chemistry - A European Journal. 7/11/2023, Vol. 29 Issue 39, p1-9. 9p.

Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours

Autor: Florian J Groelly, Manuela Porru, Jutta Zimmer, Hugo Benainous, Yanti De Visser, Anastasiya A Kosova, Serena Di Vito, Violeta Serra, Anderson Ryan, Carlo Leonetti, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-22 (2022)

Abstract The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled replication forks, which leads to replication‐associated DNA damage and genomic instability, a signature of BRCA1/2‐mutated tumours. Targeted therapies again

Externí odkaz: https://doaj.org/article/02c619b0acf544c3b51f32c37322ca42

A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line

Autor: Gunaratnam, Mekala, Collie, Gavin W., Reszka, Anthony P., Todd, Alan K., Parkinson, Gary N., Neidle, Stephen

Publikováno v: In Bioorganic & Medicinal Chemistry 15 July 2018 26(11):2958-2964